检索范围：
排序： 展示方式：
许爱国,张广财,蔚喜军,潘小飞,朱建士
《中国工程科学》 2009年 第11卷 第9期 页码 13-19
陈智斌,余永权,杨少敏
《中国工程科学》 2005年 第7卷 第3期 页码 84-89
根据石墨的形态特征，运用物元分析方法建立起关于石墨形态识别的物元模型，提出了可拓分类树方法，讨论了可拓分类树的构造和实现途径，并将其应用于石墨形态的类型判别；给出了典型的实验结果，并对该方法与现有识别方法作出比较
基于路径引导的果蝇幼虫运动合成 Research Article
陈俊君1,2,王燚军1,孙艺璇1,余益飞1,刘子奥1,龚哲峰1,4,5,郑能干1,3
《信息与电子工程前沿（英文）》 2023年 第24卷 第10期 页码 1482-1496 doi: 10.1631/FITEE.2200529
燃油喷雾形态主动控制的可能性 Review
Masataka Arai
《工程（英文）》 2019年 第5卷 第3期 页码 519-534 doi: 10.1016/j.eng.2019.04.010
Pickering乳液的发展趋势——颗粒形态及其应用 Review
Danae Gonzalez Ortiz, Celine Pochat-Bohatier, Julien Cambedouzou, Mikhael Bechelany, Philippe Miele
《工程（英文）》 2020年 第6卷 第4期 页码 468-482 doi: 10.1016/j.eng.2019.08.017
关键词： Pickering乳液 颗粒形态 二维纳米颗粒 光催化 水过滤
代谢组扩展生物学的“旁中心法则”——对理解基因组学-糖组学-代谢组学-表观基因组学互作的意义
Albert Stuart Reece
《工程（英文）》 2023年 第26卷 第7期 页码 16-16 doi: 10.1016/j.eng.2022.07.011
The central dogma of biology holds that the transcription of DNA into RNA and the translation of RNA into proteins forms the primary axis of biological activity [1]. Following major advances in the description of the complex glycan and lipid chains that are added onto these basic building blocks, the glycome and lipidome have recently been added to this doctrine as an exciting new extension named the ‘‘paracentral dogma” [2]. However, it has been pointed out that biological systems can include many layers, which are described in modern omics technology platforms relating to both cell-intrinsic and cell-extrinsic layers of control, including metabolomic, microbiomic, immunological, epigenomic, epitranscriptomic, proteomic and phosphoproteomic layers [3].
It is well known that stem and progenitor cells have a metabolism that is based on glycolysis and glutaminolysis [4]. Although this provides less energy to the cell than oxidative phosphorylation, it suffices for these cells’ needs, since such cells are generally relatively quiescent and normally suppress energy-intensive processes such as genome duplication and transcription. Moreover, it has been shown that the high intracellular lactate levels involved in such states not only inhibits the key gatekeeper enzymes of oxidative phosphorylation (i.e., pyruvate dehydrogenase and carnitine palmitoyl acyltransferase) but also actually covalently modifies them by lactylation in order to maintain this inhibited metabolic–epigenomic state [5]. In addition, intermediate metabolism and nutrients are the source of the very extensive library of post-translational modifications to DNA, RNA, and proteins, as well as supplying cellular energy for many of the required reactions. Hence, the metabolic state locks in and reinforces the epigenomic state, and the metabolome and epigenome thereby play mutually reinforcing roles. This self-reinforcing coordination explains why it is so difficult to generate induced pluripotent cells and is a contributory explanation for why the described protocols typically have such low cellular yields.
These concepts become even more important when it is considered that cancer cells are de-differentiated, similarly rely on glycolysis and glutaminolysis, and are similarly metabolically–epigenomically–genomically synchronized. The disruption of this metabolic system is a key focus of mechanistic cancer research.
These important considerations imply that the descriptive and predictive power of the newly described ‘‘paracentral dogma” of biology may be usefully and meaningfully extended by including the metabolome, along with the genome, transcriptome, proteome, glycome, and lipidome, to describe cell-intrinsic regulation—not only in terms of another omics analytical layer but also as a fully predictive and interactive partner in the symphonic-like multilayer coordination that evidently comprises cellular regulatory layering.
新孢子虫病——分子流行病学及发病机制综述 Review
Asis Khan, Jahangheer S. Shaik, Patricia Sikorski, Jitender P. Dubey, Michael E. Grigg
《工程（英文）》 2020年 第6卷 第1期 页码 10-19 doi: 10.1016/j.eng.2019.02.010
工业5.0——仿生学和合成生物学的关联及内涵 Artical
Peter Sachsenmeier
《工程（英文）》 2016年 第2卷 第2期 页码 225-229 doi: 10.1016/J.ENG.2016.02.015
仿生学(模仿生物特殊本领的学科) 以及合成生物学，将和过去50年的硅芯片一样与工程开发、工业发展产生紧密联系。化学工业已经将白色生物技术应用于新工艺、新材料和资源的可持续利用中。合成生物学也已经应用到第二代生物燃料的发展中，并利用特制的微生物或生物制催化剂获取太阳能。而仿生学在制药、处理工程以及DNA存储领域的市场潜力是巨大的。这些研究将给生物学带来新思考。生物工程将和今天的数字化技术一样驱动创新。本文讨论了生物工程，特别是碳基生物燃料的应用和细胞饰变的技术与风险。大数据、分析学和海量存储将是未来的发展方向。虽然合成生物学在未来50年将和当今的数字化一样普遍且具有革新能力，但是目前它的应用和影响力还处在初级阶段。本文采用了将生物工程发展分为五个阶段(DNA分析、生物回路、最小基因组、原始细胞、异源生物学)的普遍分类方法，阐述了其对安全与保障、工业发展以及生物工程和生物技术作为跨学科领域发展的影响，同时讨论了伦理问题及公众对仿生学和合成生物学结果的公众讨论的重要性
关键词： 仿生学 合成生物学 生物工程 生物传感器 生物燃料 生物武器 虚拟进化 原始细胞 异种细胞 经济意义 工业5.0 德国 中国
付宇涵,高欣东,师丽娟,董豪,马冬妍
《中国工程科学》 2020年 第22卷 第4期 页码 114-123 doi: 10.15302/J-SSCAE-2020.04.016
刘浩 ,柴洪峰 ,孙权 ,云昕 ,李鑫
《中国工程科学》 2023年 第25卷 第6期 页码 61-79 doi: 10.15302/J-SSCAE-2023.06.011
标题 作者 时间 类型 操作
Pickering乳液的发展趋势——颗粒形态及其应用
Danae Gonzalez Ortiz, Celine Pochat-Bohatier, Julien Cambedouzou, Mikhael Bechelany, Philippe Miele
期刊论文
新孢子虫病——分子流行病学及发病机制综述
Asis Khan, Jahangheer S. Shaik, Patricia Sikorski, Jitender P. Dubey, Michael E. Grigg
期刊论文
京公网安备 11010502051620号
