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Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling
null
《医学前沿(英文)》 2015年 第9卷 第4期 页码 444-456 doi: 10.1007/s11684-015-0421-z
Ventricular hypertrophy is a powerful and independent predictor of cardiovascular morbid events. The vascular properties of low-dose acetyl salicylic acid (aspirin) provide cardiovascular benefits through the irreversible inhibition of platelet cyclooxygenase 1; however, the possible anti-hypertrophic properties and potential mechanism of aspirin have not been investigated in detail. In this study, healthy wild-type male mice were randomly divided into three groups and subjected to transverse aortic constriction (TAC) or sham operation. The TAC-operated mice were treated with the human equivalent of low-dose aspirin (10 mg·kg−1·d−1); the remaining mice received an equal amount of phosphate buffered saline with 0.65% ethanol, which was used as a vehicle. A cardiomyocyte hypertrophy model induced by angiotensin II (10 nmol·L−1) was treated with the human equivalent of low (10 or 100 µmol·L−1) and high (1000 µmol·L−1) aspirin concentrations in plasma. Changes in the cardiac structure and function were assessed through echocardiography and transmission electron microscopy. Gene expression was determined through RT-PCR and western blot analysis. Results indicated that aspirin treatment abrogated the increased thickness of the left ventricular anterior and posterior walls, the swelling of mitochondria, and the increased surface area in in vivo and in vitro hypertrophy models. Aspirin also normalized the upregulated hypertrophic biomarkers, β-myosin heavy chain (β-MHC), atrial natriuretic peptide (ANP), and b-type natriuretic peptide (BNP). Aspirin efficiently reversed the upregulation of β-catenin and P-Akt expression and the TAC- or ANG II-induced downregulation of GSK-3β. Therefore, low-dose aspirin possesses significant anti-hypertrophic properties at clinically relevant concentrations for anti-thrombotic therapy. The downregulation of β-catenin and Akt may be the underlying signaling mechanism of the effects of aspirin.
mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?
Shi-Yong Sun
《医学前沿(英文)》 2021年 第15卷 第2期 页码 221-231 doi: 10.1007/s11684-020-0812-7
关键词: mTOR cancer therapy resistance GSK3 protein degradation E3 ubiquitin ligase PD-L1
YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng
《化学科学与工程前沿(英文)》 2007年 第1卷 第4期 页码 343-348 doi: 10.1007/s11705-007-0062-0
关键词: 4-butanediol 2-methoxyethylenoxy consistent oxetane-derived copolymer
Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice
ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong
《医学前沿(英文)》 2008年 第2卷 第1期 页码 95-99 doi: 10.1007/s11684-008-0017-y
关键词: development challenging rSj14-3-3 resistance cultural supernatant
作为免疫疗法靶点的FOXP3及其辅因子 Review
Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang
《工程(英文)》 2019年 第5卷 第1期 页码 115-121 doi: 10.1016/j.eng.2019.01.001
叉头框蛋白P3(FOXP3)是调节性T细胞(Tregs)的一个主要调节因子,调节性T细胞是能抑制抗原特异性免疫反应的T 细胞亚群,在增强宿主耐受性和维持免疫平衡方面发挥着重要作用。众所周知,FOXP3 与多种蛋白质形成复合物,并能通过乙酰化、磷酸化、泛素化和甲基化等各种翻译后修饰(PTM)进行调节。因此,翻译后修饰可改变FOXP3 的稳定性及其调节基因表达的能力,并最终影响调节性T细胞活性。虽然FOXP3 自身并非理想的药物靶点,但脱乙酰酶、乙酰转移酶、激酶和其他可调节FOXP3 的翻译后修饰的酶均为调控FOXP3 和调节性T细胞活性的潜在靶点。但FOXP3 并非这些酶的唯一底物;因此,当使用相关抑制剂时,必须考虑是否存在有害的“FOXP3脱靶”副作用。
关键词: 调节性T细胞 叉头框蛋白P3(FOXP3) 翻译后修饰 自体免疫 癌症
《医学前沿(英文)》 doi: 10.1007/s11684-023-1003-0
关键词: Lipin3 Lipin1 hypertriglyceridemia obesity mitochondrial dysfunction
Kan Wang, Chia-Che Ho, Chuck Zhang, Ben Wang
《工程(英文)》 2017年 第3卷 第5期 页码 653-662 doi: 10.1016/J.ENG.2017.05.013
Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells
LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan
《医学前沿(英文)》 2007年 第1卷 第3期 页码 269-273 doi: 10.1007/s11684-007-0051-1
关键词: 3T3-L1 influence resistance receptor substrate-1 transport
Combustion and emissions of RP-3 jet fuel and diesel fuel in a single-cylinder diesel engine
《能源前沿(英文)》 2023年 第17卷 第5期 页码 664-677 doi: 10.1007/s11708-021-0787-3
Overoxidized poly(3,4-ethylenedioxythiophene)-overoxidized polypyrrole composite films with enhanced
《化学科学与工程前沿(英文)》 2023年 第17卷 第6期 页码 735-748 doi: 10.1007/s11705-022-2262-z
关键词: overoxidized poly(3 4-ethylenedioxythiophene)-overoxidized polypyrrole rutin luteolin incubation electrocatalytic mechanism
Construction of digital 3D magic-cube organization structure for innovation-driven manufacturing
《工程管理前沿(英文)》 页码 373-390 doi: 10.1007/s42524-022-0237-x
关键词: innovation manufacturing 3D magic-cube organization structure coordination
Animage-based approach to the reconstruction of ancient architectures by extracting and arranging 3D
Divya Udayan J,HyungSeok KIM,Jee-In KIM
《信息与电子工程前沿(英文)》 2015年 第16卷 第1期 页码 12-27 doi: 10.1631/FITEE.1400141
关键词: Digital reconstruction 3D virtual world 3D spatial components Vision and scene understanding
孙学用
《中国工程科学》 2007年 第9卷 第12期 页码 94-96
增材制造(3D打印)发展趋势 Perspective
卢秉恒, 李涤尘, 田小永
《工程(英文)》 2015年 第1卷 第1期 页码 85-89 doi: 10.15302/J-ENG-2015012
增材制造又称为3D打印,在过去30年间取得了快速发展并展示出前所未有的发展潜力。同时,这项发展潜力巨大的技术对传统工业也产生了不可估量的影响。3D打印技术将会推动生产模式的变革,通过实现5个“任意”的工艺发展,将会为制造行业带来一个以定制化制造为特征的新时代。3D打印的技术进步及其与传统制造工艺的融合,将推动制造业在材料研发、产品设计、生产工艺等方面进一步创新发展。最终,3D打印技术将与等材制造、减材制造形成三足鼎立局面,共同分享整个社会的制造业价值。
标题 作者 时间 类型 操作
mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?
Shi-Yong Sun
期刊论文
Synthesis of copolymers of 3-acryloyloxymethyl-3′-methyloxetane and 3-(2-(2-(2-Methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane and their ionic conductivity properties
YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng
期刊论文
Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice
ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong
期刊论文
Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and
期刊论文
Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells
LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan
期刊论文
Overoxidized poly(3,4-ethylenedioxythiophene)-overoxidized polypyrrole composite films with enhanced
期刊论文
Construction of digital 3D magic-cube organization structure for innovation-driven manufacturing
期刊论文
Animage-based approach to the reconstruction of ancient architectures by extracting and arranging 3D
Divya Udayan J,HyungSeok KIM,Jee-In KIM
期刊论文