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作为免疫疗法靶点的FOXP3及其辅因子 Review
Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang
《工程(英文)》 2019年 第5卷 第1期 页码 115-121 doi: 10.1016/j.eng.2019.01.001
关键词: 调节性T细胞 叉头框蛋白P3(FOXP3) 翻译后修饰 自体免疫 癌症
Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3
WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng
《医学前沿(英文)》 2008年 第2卷 第4期 页码 366-369 doi: 10.1007/s11684-008-0070-6
《医学前沿(英文)》 页码 924-938 doi: 10.1007/s11684-023-1004-z
关键词: ovarian cancer lncRNA LOC646029 metastasis microRNA 627-3p SPRED1
Yan-Gang ZHAO, Zhao-Hui LU
《结构与土木工程前沿(英文)》 2011年 第5卷 第3期 页码 315-322 doi: 10.1007/s11709-011-0117-7
关键词: load and resistance factors third-moment method three-parameter lognormal (3P-lognormal) distribution target mean resistance simple formula
A comprehensive analysis of a 3-P (Pa) S spatial parallel manipulator
Yuzhe LIU,Liping WANG,Jun WU,Jinsong WANG
《机械工程前沿(英文)》 2015年 第10卷 第1期 页码 7-19 doi: 10.1007/s11465-015-0324-3
In this paper, a novel 3-degree of freedom (3-DOF) spatial parallel kinematic machine (PKM) is analyzed. The manipulator owns three main motions (two rotations and one translation) and three concomitant motions (one rotation and two translations). At first, the structure of this spatial PKM is simplified according to the characteristic of each limb. Secondly, the kinematics model of this spatial PKM is set up. In addition, the relationship between the main motions and concomitant motions is studied. The workspaces respectively based on the outputs and inputs are derived and analyzed. Furthermore, the velocity model is put forward. Two indexes based on the velocity model are employed to investigate the performance of this spatial PKM. At last, the output error model can be obtained and simulated. The comprehensive kinematics analysis in this paper is greatly useful for the future applications of this spatial PKM.
关键词: parallel mechanism concomitant motions kinematics workspaces error model
RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway
《医学前沿(英文)》 2023年 第17卷 第1期 页码 143-155 doi: 10.1007/s11684-022-0929-y
null
《医学前沿(英文)》 2015年 第9卷 第3期 页码 331-343 doi: 10.1007/s11684-015-0409-8
MicroRNAs (miRNAs), an important class of small non-coding RNAs, regulate gene expression at the post-transcriptional level. miRNAs are involved in a wide range of biological processes and implicated in different diseases, including cancers. In this study, miRNA profiling and qRT-PCR validation revealed that miR-142-3p and miR-142-5p were significantly downregulated in hepatocellular carcinoma (HCC) and their expression levels decreased as the disease progressed. The ectopic expression of miR-142 significantly reduced HCC cell migration and invasion. Overexpression of either miR-142-3p or miR-142-5p suppressed HCC cell migration, and overexpression of both synergistically inhibited cell migration, which indicated that miR-142-3p and miR-142-5p may cooperatively regulate cell movement. miR-142-3p and miR-142-5p, which are mature miRNAs derived from the 3′- and 5′-strands of the precursor miR-142, target distinct pools of genes because of their different seed sequences. Pathway enrichment analysis showed a strong association of the putative gene targets of miR-142-3p and miR-142-5p with several cell motility-associated pathways, including those regulating actin cytoskeleton, adherens junctions, and focal adhesion. Importantly, a number of the putative gene targets were also significantly upregulated in human HCC cells. Moreover, overexpression of miR-142 significantly abrogated stress fiber formation in HCC cells and led to cell shrinkage. This study shows that mature miR-142 pairs collaboratively regulate different components of distinct signaling cascades and therefore affects the motility of HCC cells.
关键词: hepatocellular carcinoma microRNA metastasis cytoskeletal reorganization
宁平,Hans-JörgBart,王学谦,马丽萍,陈梁
《中国工程科学》 2005年 第7卷 第6期 页码 27-35
MARTÍNEZ-GALVÁN, Miguel P. ROMO
《结构与土木工程前沿(英文)》 2018年 第12卷 第1期 页码 67-80 doi: 10.1007/s11709-017-0399-5
关键词: deep foundations bearing capacity resistant moment structural cell 3D numerical modeling
基于液滴微流控的分级结构反蛋白石多孔支架用于仿生三维细胞共培养 Article
邵长敏, 刘羽霄, 池俊杰, 叶方富, 赵远锦
《工程(英文)》 2021年 第7卷 第12期 页码 1778-1785 doi: 10.1016/j.eng.2020.06.031
YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng
《化学科学与工程前沿(英文)》 2007年 第1卷 第4期 页码 343-348 doi: 10.1007/s11705-007-0062-0
关键词: 4-butanediol 2-methoxyethylenoxy consistent oxetane-derived copolymer
张正峰,付金强,张发瑜
《中国工程科学》 2007年 第9卷 第5期 页码 53-56
Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice
ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong
《医学前沿(英文)》 2008年 第2卷 第1期 页码 95-99 doi: 10.1007/s11684-008-0017-y
关键词: development challenging rSj14-3-3 resistance cultural supernatant
Adsorption of 1,3-propanediol from synthetic mixture using polymeric resin as adsorbents
TANTAYAKOM, P. PRASITCHOKE, C. MUANGNAPOH
《化学科学与工程前沿(英文)》 2009年 第3卷 第1期 页码 52-57 doi: 10.1007/s11705-009-0087-7
关键词: adsorption 1 3-propanediol glycerol polymeric resin adsorption isotherm
标题 作者 时间 类型 操作
Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3
WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng
期刊论文
noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p
期刊论文
Estimation of load and resistance factors using the third-moment method based on the 3P-lognormal distribution
Yan-Gang ZHAO, Zhao-Hui LU
期刊论文
A comprehensive analysis of a 3-P (Pa) S spatial parallel manipulator
Yuzhe LIU,Liping WANG,Jun WU,Jinsong WANG
期刊论文
MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic
null
期刊论文
虞晓含:中医话健康,食补改善免疫力(2020年3月1日)
2022年04月18日
会议视频
Assessment of an alternative to deep foundations in compressible clays: the structural cell foundation
MARTÍNEZ-GALVÁN, Miguel P. ROMO
期刊论文
Synthesis of copolymers of 3-acryloyloxymethyl-3′-methyloxetane and 3-(2-(2-(2-Methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane and their ionic conductivity properties
YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng
期刊论文
Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice
ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong
期刊论文