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Strategic Study of CAE >> 2014, Volume 16, Issue 5

The case-control study of the antinomy and congenital heart disease

Fujian Provincial Maternity and Child Health Hospital,Teaching Hospital of Fujian Medical University,Fuzhou 350000,China

Funding project:福建临床重点专科建设资助项目[闽卫科教(2012)92号];福建省科技计划项目(2012Y0011);国家重点基础研究发展计划项目腔北调(2010CB529501) Received: 2014-04-08 Available online: 2014-05-26 15:13:53.000

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Abstract

Using 69 paired cases and controls,a 1∶1 matched case control study was carried out in Fujian Maternal and Child Health Hospital. Factors were obtained by field investigation with standardized questionnaires and hair trace element (Sb,Zn,Cu,Fe,Pb,etc.) levels were determined by inductively coupled plasma mass spectrometry (ICP- MS) methods. The SPSS 19.0 Cox proportional hazard model was used to perform risk factors analysis. Results :The antinomy contents from congenital heart disease (CHD) groups’hairs were significantly higher than that from control group (P=0.000). The larger antinomy content in pregnant women’s hair may expose their babies to a higher risk of CHD (odds ratio(OR)=33.833;95 % confidence interval (CI):4.060~281.929). Using stainless steel tableware after the first three weeks of pregnancy (OR=8.981,95 % CI:1.085~74.327) and living around 50 m from the road (OR=11.067,95 % CI:1.025~119.521) turn out to be the major risk factors of CHD. The increase of antinomy content in pregnant women’s hair may be a risk factor of CHD.

References

[ 1 ] Van der Linde D,Konings E E,Slager M A,et al. Birth prevalence of congenital heart disease worldwide:A systematic review and meta-analysis [J]. Journal of the American College of Cardiology,2011,58(21):2241-2247. link1

[ 2 ] 刘小清,麦劲状,高向民,等. 广东省中西南北部地区婴儿先天 性心脏病的发病状况分析[J]. 中华心血管病杂志,2013,41(4): 337-340. link1

[ 3 ] Czeizel A E,Rockenbauer M,Sørensen H T,et al. The teratogenic risk of trimethoprim- sulfonamides:A population based case- control study [J]. Reproductive Toxicology,2001,15(6): 637-646. link1

[ 4 ] Bukowiecki N,Lienemann P,Hill M,et al. Real-world emission factors for antimony and other brake wear related trace elements: Size-segregated values for light and heavy duty vehicles [J]. Environmental Science & Technology,2009,43(21):8072-8078. link1

[ 5 ] 宁增平,肖唐付. 锑的表生地球化学行为与环境危害效应[J]. 地 球与环境,2007,35(2):176-182. link1

[ 6 ] 客绍英,石洪凌,刘冬莲. 锑的污染及其毒性效应和生物有效性 [J]. 化学世界,2005,46(6):382-384. link1

[ 7 ] 方克美,杨大明,常 俊. 急性中毒治疗学[M]. 南京:江苏科学 技术出版社,2002.

[ 8 ] 戈兆凤,韦朝阳. 锑环境健康效应的研究进展[J]. 环境与健康杂 志,2011,28(7):649-653. link1

[ 9 ] Filella M,Belzile N,Chen Y W. Human exposure to antimony. Ⅱ. Contents in some human tissues often used in biomonitoring (hair,nails,teeth) [J]. Critical Reviews in Environmental Science and Technology,2012,42(10):1058-1115. link1

[10] Callahan M A. Water-related environmental fate of 129 priority pollutants [M]. US:Office of Water Planning and Standards, Office of Water and Waste Management,Environmental Protection Agency,1979.

[11] Kuroda K,Endo G,Okamoto A,et al. Genotoxicity of beryllium,gallium and antimony in short- term assays [J]. Mutation Research Letters,1991,264(4):163-170. link1

[12] Schaumlöffel N,Gebel T. Heterogeneity of the DNA damage provoked by antimony and arsenic[J]. Mutagenesis,1998,13(3): 281-286. link1

[13] Wey H E,Richards D,Tirmenstein M A,et al. The role of intracellular calcium in antimony-induced toxicity in cultured cardiac myocytes [J]. Toxicology and Applied Pharmacology,1997, 145(1):202-210. link1

[14] Tirmenstein M A,Plews P I,Walker C V,et al. Antimony-induced oxidative stress and toxicity in cultured cardiac myocytes [J]. Toxicology and Applied Pharmacology,1995,130(1):41-47. link1

[15] Bento D B,De Souza B,Steckert A V,et al. Oxidative stress in mice treated with antileishmanial meglumine antimoniate [J]. Research in Veterinary Science,2013,95(3):1134-1141. link1

[16] 崔 凯,蔡治英. 儿童先天性心脏病的发病原因及防治研究 [J]. 中国社区医师,2009,11 (18):14. link1

[17] Iijima A,Sato K,Fujitani Y,et al. Clarification of the predominant emission sources of antimony in airborne particulate matter and estimation of their effects on the atmosphere in Japan [J]. Environmental Chemistry,2009,6(2):122-132. link1

[18] Bukowiecki N,Lienemann P,Hill M,et al. Real-world emission factors for antimony and other brake wear related trace elements:Size-segregated values for light and heavy duty vehicles [J]. Environmental Science & Technology,2009,43(21):8072- 8078. link1

[19] Furuta N,Iijima A,Kambe A,et al. Concentrations,enrichment and predominant sources of Sb and other trace elements in size classified airborne particulate matter collected in Tokyo from 1995 to 2004 [J]. Journal of Environmental Monitoring,2005,7 (12):1155-1161. link1

[20] 印德俊. 不锈钢中微量锑的光度法测定[J]. 四川冶金,1989 (4):81-82. link1

[21] 张卫国,黄秋婵,韦友欢. 浅谈不锈钢餐具与人体健康[J]. 微量 元素与健康研究,2008,25(5):60-61. link1

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