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Data mining of microarray for differentially expressed genes in liver metastasis from gastric cancer
Ling XU MM, Feng WANG MM, Xuan-Fu XU MD, Wen-Hui MO BM, Rong WAN MD, Chuan-Yong GUO MD, Xing-Peng WANG MD,
Frontiers of Medicine 2010, Volume 4, Issue 2, Pages 247-253 doi: 10.1007/s11684-010-0027-4
Keywords: gastric carcinoma metastasis signal transduction gene chips
Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells
Yi Liang,Qisheng Feng,Jian Hong,Futuo Feng,Yi Sang,Wenrong Hu,Miao Xu,Roujun Peng,Tiebang Kang,Jinxin Bei,Yixin Zeng
Frontiers of Medicine 2015, Volume 9, Issue 1, Pages 57-62 doi: 10.1007/s11684-015-0389-8
The existence of cancer stem cells, stem-like cancer cells (SLCCs), or tumor-initiating cells is considered as the cause of tumor formation and recurrence, indicating the importance of studying novel therapy that targets SLCCs. The origin of SLCCs is controversial because of two competing hypotheses: SLCCs are either transformed from tissue adult stem cells or dedifferentiated from transformed progenitor cells. Our previous research demonstrates that SLCCs are inducible by increasing genomic instability in cancer cells. In this study, to block the emergence of SLCCs, aminoethyl isothiourea (AET), a compound that clears free radicals and is used to protect patients from radioactive exposure, was used as an agent that maintains genomic stability in combination with mitomycin C (MMC), a commonly used chemotherapeutic drug that damages DNA. Using a rabbit tumor model with VX2 hepatic carcinoma, we found that MMC alone increased lung metastases and disadvantaged survival outcome, but the combination of MMC and AET reversed this effect and even prolonged overall survival. Moreover, in a VX2 xenograft model by immunocompromised mice, MMC alone enriched tumor-initiating cells, but the administration of MMC in combination with AET eliminated tumor cells effectively. Furthermore, MMC alone enhanced genomic instability, but MMC combined with AET attenuated the extent of genomic instability in primary VX2 tumor tissue. Taken together, our data suggest that the genomic protector AET can inhibit the induction of SLCCs, and this combination treatment by AET and cytotoxic agents should be considered as a promising strategy for future clinical evaluation.
Keywords: rabbit VX2 liver tumor mitomycin C AET stem-like cancer cells genomic instability
Yugang Cheng,Hanxiang Zhan,Lei Wang,Jianwei Xu,Guangyong Zhang,Zongli Zhang,Sanyuan Hu
Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 444-450 doi: 10.1007/s11684-016-0471-x
Keywords: pancreatic neuroendocrine neoplasms clinicopathological characteristic Ki-67 liver metastasis outcomes
Tian Wang, Yan Li, Abidan Tuerhanjiang, Wenwen Wang, Zhangying Wu, Ming Yuan, Shixuan Wang
Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 106-112 doi: 10.1007/s11684-014-0307-5
Cervical carcinoma is associated with high propensity for local invasion and lymph node metastasisHowever, the molecular alterations that drive progression and metastasis of cervical cancer remain unclearThis gene also exhibits a positive function in regulating invasion and metastasis.The strong positive expressions of Twist in the SCC groups with or without lymph node metastasis wereOur results suggested that the expression of Twist increased during the progression and metastasis of
Keywords: cervical cancer senescence Twist CBX3 lymph node metastasis
Frontiers of Medicine 2022, Volume 16, Issue 6, Pages 883-895 doi: 10.1007/s11684-022-0919-0
Keywords: osteosarcoma autophagy metastasis drug resistance Beclin1 LC3B
Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies
Lunxiu Qin
Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 24-32 doi: 10.1007/s11684-014-0312-8
In this review, we summarize the novel findings from our series of studies on the leading metastasis-relatedgene expression profiling study, OPN was identified as one of the leading genes associated with the metastasisWe focused on OPN to evaluate its prognostic values and important roles in HCC metastasis.both in vitro and in vivoinvestigations, we found that OPN has an important role in metastasisand tumor growth of HCC and is an attractive potential therapeutic target for combating HCC metastasis
Keywords: osteopontin (OPN) hepatocellular carcinoma metastasis prognosis therapeutic target biomarker genetic
Nianqiao GONG, Xiaoping CHEN
Frontiers of Medicine 2011, Volume 5, Issue 1, Pages 1-7 doi: 10.1007/s11684-010-0105-7
Partial liver transplantation, including reduced-size liver transplantation, split liver transplantation, and living donor liver transplantation, has been developed with several innovative techniques becauseSplit liver transplantation provides chances to two or even more recipients when only one liver graftBefore surgery, a series of donor evaluations—including anatomical, liver volume, and liver functionAt different recipient conditions, auxiliary liver transplantation and auxiliary partial orthotopic liver
Keywords: partial liver transplantation reduced-size liver transplantation split liver transplantation living donorliver transplantation
Xuefu Wang, Zhigang Tian
Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 262-268 doi: 10.1007/s11684-017-0584-x
Keywords: γδT cells liver infection non-alcoholic fatty liver disease autoimmune hepatitis liver fibrosis and cirrhosis liver cancer liver regeneration
Shasha Zhu, Huimin Zhang, Li Bai
Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 249-261 doi: 10.1007/s11684-018-0622-3
Keywords: natural killer T cells hepatitis B virus and hepatitis C virus infection autoimmune liver diseases alcoholicliver disease nonalcoholic fatty liver disease hepatocellular carcinoma
Natural killer cells in liver diseases
Meijuan Zheng, Haoyu Sun, Zhigang Tian
Frontiers of Medicine 2018, Volume 12, Issue 3, Pages 269-279 doi: 10.1007/s11684-018-0621-4
The liver has been characterized as a frontline lymphoid organ with complex immunological featuressuch as liver immunity and liver tolerance.Liver tolerance plays an important role in liver diseases including acute inflammation, chronic infectionThe liver contains a large proportion of natural killer (NK) cells, which exhibit heterogeneity in phenotypicUnder the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immune
Keywords: natural killer cell phenotype immune activation immune tolerance liver diseases
Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu
Frontiers of Medicine 2021, Volume 15, Issue 3, Pages 495-505 doi: 10.1007/s11684-020-0790-9
Keywords: hepatitis B virus-related liver failure traditional Chinese medicine liver regeneration liver regeneration
Assessment of liver volume variation to evaluate liver function
Cong Tong, Xinsen Xu, Chang Liu, Tianzheng Zhang, Kai Qu
Frontiers of Medicine 2012, Volume 6, Issue 4, Pages 421-427 doi: 10.1007/s11684-012-0223-5
In order to assess the value of liver volumetry in cirrhosis and acute liver failure (ALF) patientsto get a regression formula for standard liver volume (SLV) and BSA.It turned out that the mean liver volume of the control group was 1 058±337 cm3.Child A, B level was not reduced, but in Child C level it was significantly reduced with the lowest liverIn conclusion, the CTLV/SLV ratio, which reflects liver volume variations, correlates well with the liver
Keywords: liver volume variation cirrhosis acute liver failure (ALF)
Frontiers of Medicine 2022, Volume 16, Issue 4, Pages 551-573 doi: 10.1007/s11684-022-0928-z
Keywords: HCC bone osteotropism clinical basic researches advances
Gut microbial balance and liver transplantation: alteration, management, and prediction
Xinyao Tian, Zhe Yang, Fangzhou Luo, Shusen Zheng
Frontiers of Medicine 2018, Volume 12, Issue 2, Pages 123-129 doi: 10.1007/s11684-017-0563-2
Liver transplantation is a conventional treatment for terminal stage liver diseases.Intestinal barrier destruction is widely observed among patients receiving liver transplant and sufferingThis article reviews the research progress for gut microbial alterations and liver transplantation.microbial alteration and the prediction of possible injuries utilizing microbial alteration during liverand offer a hypothesis on the utilization of microbial alteration in liver transplantation.
Keywords: gut microbial balance liver transplantation ischemia–reperfusion acute rejection
Molecular mechanisms of fatty liver in obesity
Lixia Gan,Wei Xiang,Bin Xie,Liqing Yu
Frontiers of Medicine 2015, Volume 9, Issue 3, Pages 275-287 doi: 10.1007/s11684-015-0410-2
Nonalcoholic fatty liver disease (NAFLD) covers a spectrum of liver disorders ranging from simplesteatosis, which is characterized by excessive accumulation of triglyceride-rich lipid droplets in the liverAccumulating evidence supports that dysregulation of adipose lipolysis and liver de novo&
Keywords: nonalcoholic fatty liver disease insulin resistance obesity
Title Author Date Type Operation
Data mining of microarray for differentially expressed genes in liver metastasis from gastric cancer
Ling XU MM, Feng WANG MM, Xuan-Fu XU MD, Wen-Hui MO BM, Rong WAN MD, Chuan-Yong GUO MD, Xing-Peng WANG MD,
Journal Article
Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells
Yi Liang,Qisheng Feng,Jian Hong,Futuo Feng,Yi Sang,Wenrong Hu,Miao Xu,Roujun Peng,Tiebang Kang,Jinxin Bei,Yixin Zeng
Journal Article
Analysis of 100 consecutive cases of resectable pancreatic neuroendocrine neoplasms: clinicopathological characteristics and long-term outcomes
Yugang Cheng,Hanxiang Zhan,Lei Wang,Jianwei Xu,Guangyong Zhang,Zongli Zhang,Sanyuan Hu
Journal Article
Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical
Tian Wang, Yan Li, Abidan Tuerhanjiang, Wenwen Wang, Zhangying Wu, Ming Yuan, Shixuan Wang
Journal Article
Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance
Journal Article
Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies
Lunxiu Qin
Journal Article
The “Traditional Chinese medicine regulating liver regeneration” treatment plan for reducing mortalityof patients with hepatitis B-related liver failure based on real-world clinical data
Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu
Journal Article
Assessment of liver volume variation to evaluate liver function
Cong Tong, Xinsen Xu, Chang Liu, Tianzheng Zhang, Kai Qu
Journal Article
Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives
Journal Article
Gut microbial balance and liver transplantation: alteration, management, and prediction
Xinyao Tian, Zhe Yang, Fangzhou Luo, Shusen Zheng
Journal Article