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Neutralizing monoclonal antibodies present new prospects to treat SARS-CoV-2 infections

Rongtao Lai, Tianhui Zhou, Xiaogang Xiang, Jie Lu, Haiguang Xin, Qing Xie

Frontiers of Medicine 2021, Volume 15, Issue 4, Pages 644-648 doi: 10.1007/s11684-021-0847-4

Abstract: The development of a broadly neutralizing antibody against severe acute respiratory syndrome coronavirusCurrently, the receptor-binding domain (RBD) of the spike (S) protein is the main target of neutralizingA single monoclonal antibody (mAb) treatment is prone to selective pressure due to increased possibilityIn addition, the antibody-dependent enhancement effect is a potential risk of enhancing the viral infection

Keywords： neutralizing antibody antibody cocktail SARS-CoV-2 COVID-19 therapeutic strategy

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Neutralization against SARS-CoV-2 Delta/Omicron variants and B cell response after inactivated vaccination among COVID-19 convalescents

Frontiers of Medicine Pages 747-757 doi: 10.1007/s11684-022-0954-x

Abstract: The neutralizing antibody (NAb) titers against the wild-type virus continued to decrease in the no-vaccination

Keywords： COVID-19 convalescent SARS-CoV-2 inactivated vaccination neutralizing antibody B cell response

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Recent advances in “universal” influenza virus antibodies: the rise of a hidden trimeric interface in hemagglutinin globular head

Yulu Wang, Dan Hu, Yanling Wu, Tianlei Ying

Frontiers of Medicine 2020, Volume 14, Issue 2, Pages 149-159 doi: 10.1007/s11684-020-0764-y

Abstract: discovered recently, and a number of antibodies targeting these epitopes have been found to be capable of neutralizing

Keywords： influenza virus neutralizing antibody hemagglutinin globular head region trimeric interface

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Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Qian Wang, Linqi Zhang

Frontiers of Medicine 2020, Volume 14, Issue 1, Pages 30-42 doi: 10.1007/s11684-019-0721-9

Abstract: Recent discoveries in broadly neutralizing monoclonal antibodies (bNAbs) has led to the development ofmultiple novel vaccine approaches for inducing bNAbs-like antibody response.

Keywords： HIV-1 broadly neutralizing antibodies Env conformational states vaccine design SOSIP

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Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection

Yun Tan, Feng Liu, Xiaoguang Xu, Yun Ling, Weijin Huang, Mingquan Guo, Ziyu Fu, Dongguo Liang, Miao Xu, Hongzhou Lu, Saijuan Chen

Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 746-751 doi: 10.1007/s11684-020-0822-5

Abstract: Notably, 14 samples available at 6−7 months post-infection all showed significant neutralizing activities

Keywords： SARS-CoV-2 neutralizing antibodies T-cell response

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BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation

Frontiers of Medicine doi: 10.1007/s11684-023-0996-8

Abstract: Here, we discovered that BGB-A445, a non-ligand-competitive agonistic anti-OX40 antibody currently underdose-dependently and significantly depleted regulatory T cells in vitro and in vivo via antibody-dependentdemonstrated robust and dose-dependent antitumor efficacy, whereas the ligand-competitive anti-OX40 antibodyFurthermore, BGB-A445 demonstrated a strong combination antitumor effect with an anti-PD-1 antibody.

Keywords： BGB-A445 OX40 agonistic antibody OX40L noncompetitive

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Production of a polyclonal antibody to the VP26 nucleocapsid protein of white spot syndrome virus (wssv

Suchera LOYPRASERT-THANANIMIT, Akrapon SALEEDANG, Proespichaya KANATHARANA, Panote THAVARUNGKUL, Wilaiwan CHOTIGEAT

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 2, Pages 216-223 doi: 10.1007/s11705-012-1289-y

Abstract: The objective of this work was to produce a polyclonal antibody against VP26 and use it as a biosensorprotein (rVP26) was produced in (BL21), purified and used for immunizing rabbits to obtain a polyclonal antibody

Keywords： recombinant protein polyclonal antibody label-free biosensor impedance white spot syndrome virus (WSSV

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Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12

Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang

Frontiers of Medicine 2019, Volume 13, Issue 1, Pages 83-93 doi: 10.1007/s11684-019-0682-z

Abstract: Recently, treatments using cetuximab, also named C225, an anti-EGFR monoclonal antibody, for CRC haveand S492R EGFR accelerate the growth of CRC cells in vitro and in vivo and monoclonal antibodyFurthermore, mAb CH12 showed significantly stronger growth suppression activities and induced a more potent antibody-dependent

Keywords： S492R EGFR ectodomain mutation colorectal cancer mAb CH12 immunnotherapy

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Preparation of hapten-specific monoclonal antibody for cadmium and its ELISA application to aqueous samples

Huan HE, Bo TANG, Cheng SUN, Shaogui YANG, Weijuan ZHENG, Zichun HUA

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 3, Pages 409-416 doi: 10.1007/s11783-011-0349-8

Abstract: The monoclonal antibody with high level of binding affinity for Cd-IEDTA-BSA and high specificity for

Keywords： cadmium hapten monoclonal antibody enzyme-linked immunosorbent assay (ELISA)

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CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells

Jiangnan Liu,Bin Yi,Zhe Zhang,Yi Cao

Frontiers of Medicine 2016, Volume 10, Issue 2, Pages 204-211 doi: 10.1007/s11684-016-0443-1

Abstract: A positive clone of CD176 single-chain variable antibody fragment (scFv) was successfully screened from

Keywords： CD176 Thomsen-Friedenreich antigen scFv cancer therapy adhesion metastasis

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Modified Therapeutic Antibodies: Improving Efficacy Review

Ji-Min Dai, Xue-Qin Zhang, Jing-Yao Dai, Xiang-Min Yang, Zhi-Nan Chen

Engineering 2021, Volume 7, Issue 11, Pages 1529-1540 doi: 10.1016/j.eng.2020.06.030

Abstract: of crystallizable domain (Fc) amino acid alterations; ③ cross-isotype or cross-subclass exchanges; ④ antibody

Keywords： Therapeutic antibody Modification Efficacy Antigen Antibody–drug conjugate Bispecific antibody

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the Spike Protein Expressed in Glycoengineered Pichia pastoris Targeting SARS-CoV-2 Stimulates Neutralizingand Protective Antibody Responses Article

Bo Liu, Ying Yin, Yuxiao Liu, Tiantian Wang, Peng Sun, Yangqin Ou, Xin Gong, Xuchen Hou, Jun Zhang, Hongguang Ren, Shiqiang Luo, Qian Ke, Yongming Yao, Junjie Xu, Jun Wu

Engineering 2022, Volume 13, Issue 6, Pages 107-115 doi: 10.1016/j.eng.2021.06.012

Abstract: The candidate vaccine effectively stimulated mice to produce high-titer anti-RBD specific antibody.Furthermore, the specific antibody titer and virus-neutralizing antibody (NAb) titer induced by the vaccinethe RBD of the S glycoprotein expressed in glycoengineered Pichia pastoris, which stimulates neutralizingand protective antibody responses.

Keywords： Coronavirus SARS-CoV-2 Vaccine Yeast Receptor-binding domain (RBD)

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Optimal Antibody Purification Strategies Using Data-Driven Models Article

Songsong Liu, Lazaros G. Papageorgiou

Engineering 2019, Volume 5, Issue 6, Pages 1077-1092 doi: 10.1016/j.eng.2019.10.011

Abstract:

This work addresses the multiscale optimization of the purification processes of antibody fragmentsnonlinear programming (MINLP) models are proposed to minimize the total cost of goods per gram of the antibody

Keywords： Antibody purification Multiscale optimization Antigen-binding fragment Mixed-integer programming

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A Novel Human Antibody, HF, against HER2/erb-B2 Obtained by a Computer-Aided Antibody Design Method Article

Chunxia Qiao, Ming Lv, Xinying Li, Xiaoling Lang, Shouqin Lv, Mian Long, Yan Li, Shusheng Geng, Zhou Lin, Beifen Shen , Jiannan Feng

Engineering 2021, Volume 7, Issue 11, Pages 1566-1576 doi: 10.1016/j.eng.2020.10.024

Abstract: At present, most potential antibody drugs in clinical trials are humanized or fully human.Here, we describe a structure-based computer-aided de novo design technology for human antibody generationcomplementarity determining regions in a suitable immunoglobulin frame, giving birth to a novel anti-HER2 antibody

Keywords： HER2/erb-B2 Human antibody Computer-aided design

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From SARS to MERS: evidence and speculation

Hainv Gao,Hangping Yao,Shigui Yang,Lanjuan Li

Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 377-382 doi: 10.1007/s11684-016-0466-7

Abstract:

The Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel zoonotic pathogen. In 2012, the infectious outbreak caused by MERS-CoV in Saudi Arabia has spread to more than 1600 patients in 26 countries, resulting in over 600 deaths. Without a travel history, few clinical and radiological features can reliably differentiate MERS from SARS. But in real world, comparing with SARS, MERS presents more vaguely defined epidemiology, more severe symptoms, and higher case fatality rate. In this review, we summarize the recent findings in the field of MERS-CoV, especially its molecular virology, interspecies mechanisms, clinical features, antiviral therapies, and the further investigation into this disease. As a newly emerging virus, many questions are not fully answered, including the exact mode of transmission chain, geographical distribution, and animal origins. Furthermore, a new protocol needs to be launched to rapidly evaluate the effects of unproven antiviral drugs and vaccine to fasten the clinical application of new drugs.

Keywords： middle east respiratory syndrome animal origin cross-species transmission monoclonal antibody

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Title Author Date Type Operation

Neutralizing monoclonal antibodies present new prospects to treat SARS-CoV-2 infections

Rongtao Lai, Tianhui Zhou, Xiaogang Xiang, Jie Lu, Haiguang Xin, Qing Xie

Journal Article

Neutralization against SARS-CoV-2 Delta/Omicron variants and B cell response after inactivated vaccination among COVID-19 convalescents

Journal Article

Recent advances in “universal” influenza virus antibodies: the rise of a hidden trimeric interface in hemagglutinin globular head

Yulu Wang, Dan Hu, Yanling Wu, Tianlei Ying

Journal Article

Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Qian Wang, Linqi Zhang

Journal Article

Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection

Yun Tan, Feng Liu, Xiaoguang Xu, Yun Ling, Weijin Huang, Mingquan Guo, Ziyu Fu, Dongguo Liang, Miao Xu, Hongzhou Lu, Saijuan Chen

Journal Article

BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation

Journal Article

Production of a polyclonal antibody to the VP26 nucleocapsid protein of white spot syndrome virus (wssv

Suchera LOYPRASERT-THANANIMIT, Akrapon SALEEDANG, Proespichaya KANATHARANA, Panote THAVARUNGKUL, Wilaiwan CHOTIGEAT

Journal Article

Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12

Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang

Journal Article

Preparation of hapten-specific monoclonal antibody for cadmium and its ELISA application to aqueous samples

Huan HE, Bo TANG, Cheng SUN, Shaogui YANG, Weijuan ZHENG, Zichun HUA

Journal Article

CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells

Jiangnan Liu,Bin Yi,Zhe Zhang,Yi Cao

Journal Article

Modified Therapeutic Antibodies: Improving Efficacy

Ji-Min Dai, Xue-Qin Zhang, Jing-Yao Dai, Xiang-Min Yang, Zhi-Nan Chen

Journal Article

the Spike Protein Expressed in Glycoengineered Pichia pastoris Targeting SARS-CoV-2 Stimulates Neutralizingand Protective Antibody Responses

Bo Liu, Ying Yin, Yuxiao Liu, Tiantian Wang, Peng Sun, Yangqin Ou, Xin Gong, Xuchen Hou, Jun Zhang, Hongguang Ren, Shiqiang Luo, Qian Ke, Yongming Yao, Junjie Xu, Jun Wu

Journal Article

Optimal Antibody Purification Strategies Using Data-Driven Models

Songsong Liu, Lazaros G. Papageorgiou

Journal Article

A Novel Human Antibody, HF, against HER2/erb-B2 Obtained by a Computer-Aided Antibody Design Method

Chunxia Qiao, Ming Lv, Xinying Li, Xiaoling Lang, Shouqin Lv, Mian Long, Yan Li, Shusheng Geng, Zhou Lin, Beifen Shen , Jiannan Feng

Journal Article

From SARS to MERS: evidence and speculation

Hainv Gao,Hangping Yao,Shigui Yang,Lanjuan Li

Journal Article