Search | Engineering

Subscribe Submit

Home Journals Focus Achievement Fronts About Us 中文版

Resource Type

Journal Article 1081

Conference Videos 25

Conference Information 4

Year

2024 2

2023 167

2022 174

2021 191

2020 95

2019 40

2018 26

2017 49

2016 30

2015 35

2014 45

2013 41

2012 21

2011 23

2010 43

2009 29

2008 19

2007 33

2006 3

2005 2

open ︾

Keywords

SARS-CoV-2 33

COVID-19 25

CO₂ capture 19

2 18

TiO₂ 14

CO₂ 9

1 8

Photocatalysis 8

photocatalysis 8

CO₂ emissions 7

Deep learning 7

Al₂O₃ 6

Reinforcement learning 6

microwave scatterometer 5

H₂S 4

MnO₂ 4

N₂O 4

biomass 4

type 2 diabetes 4

open ︾

Search scope:

排序： Display mode:

Protein phosphatase 2A, a key player in Alzheimer’s disease

Rong LIU, Qing TIAN

Frontiers of Medicine 2009, Volume 3, Issue 1, Pages 8-12 doi: 10.1007/s11684-009-0017-6

Abstract: Protein phosphatase 2A (PP2A) is the predominant serine/threonine phosphatase in eukaryotic cells.Based on our research and other previous findings, decreased PP2Ac level, decreased PP2A holoenzyme composition, increased level of PP2A inhibitors, increased PP2Ac Leu309 demethylation and Tyr307 phosphorylationmetabolism are the possible up-stream factors that inactivate PP2A in AD neurons.Further studies are required to disclose the role of PP2A in Alzheimer’s disease.

Keywords： protein phosphatase 2A Alzheimer’s disease holoenzyme composition protein phosphatase 2A inhibitors Leu309

HTML PDF Collect

Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Frontiers of Medicine 2008, Volume 2, Issue 3, Pages 235-238 doi: 10.1007/s11684-008-0044-8

Abstract: investigate the effect of tyrosine kinase Src on Tyrosine 307(Y307) phosphorylation, protein phosphatase 2A(PP2A) activity, and on tau phosphorylation.of Src protein, and the phosphorylation levels of PP2A Y307 and tau at different sites, as well as PP2AHowever, the total PP2A protein level was also decreased, together with a decreased PP2A activity.Multiple factors may be involved in the cellular regulation of PP2A activity.

Keywords： hyperphosphorylation PP2A activity cellular regulation siRNA siRNA transfection

HTML PDF Collect

Complete Genome Sequence of Shigella flexneri 2a 301 Strain and Analysis of “Shigella-islands”

Liu Hong,Yang Fan,Zhang Xiaobing,Zhang Jiyu,Yang Guowei,Dong Jie,Xue Ying,Hou Yunde,Yuan Zhenghong,Wen Yumei,Xu Jianguo,Cheng Hongsong,Ma Dalong,Wang Yu,Yang Jian,Shen Yan,Qiang Boqin,Wu Hongtao,Lü Weichuan,Jin Qi

Strategic Study of CAE 2002, Volume 4, Issue 10, Pages 40-47

Abstract:

Shigella flexneri serotype 2a are the most prevalent species and serotype that cause .bacillary dysenteryThis paper presents the complete genome sequence of a Shigella flexneri 2a strain which isolated fromthe primary analysis of “ Shigella-genomic islands (SIs)，” that means Shigella flexneri 2athem, the authors identified 7 putative Sis with typical structure of pathogenicity islands (PAI) and 2lipopolysaccharide (LPS) have implications in virulence, in addition to the previously identified PAIs, SHE and SHI-2.

Keywords： Shigella flexneri 2a 301 strain genome sequence genomic island pathogenicity island

HTML PDF Collect

第三届环境、工业和能源工程国际会议(EI2E 2019)

Conference Date: 19 Sep 2019

Conference Place: 宁夏银川

Administered by: APISE

第四届设计、机械和材料工程国际会议(D2ME 2019)

Conference Date: 26 Sep 2019

Conference Place: 釜山，韩国

Administered by: HKSME

Xiao Yonghong: Co-evolution of Clinical Highly Resistant and Highly Toxic Pathogens (2023-2-22)

10 Mar 2023

Keywords：代谢与免疫

第四届设计、机械和材料工程国际会议(D2ME 2019)

Conference Date: 26 Sep 2019

Conference Place: 釜山，韩国

Administered by: HKSME

Between Physical Activity, Sedentary Behavior and Cardiovascular Disease risk in Patients with Type 2Diabetes: MlDiab Study (2023-2-21)

2 Mar 2023

Keywords：营养健康

Shenshizhao: Large Span Structure (2018-6-2)

22 Apr 2021

Keywords：光学技术

Jian Li：iScience and Interdisciplinary Research (2020-4-2)

18 Apr 2022

Keywords：工程管理

Jin Yong: Expansion of Chemical Reaction Scale (2018-6-2)

22 Apr 2021

Keywords：化工

Academician Xu Mi Interpretation of China's Nuclear Energy (2018-6-2)

22 Apr 2021

Keywords：核能

Sun Jinsheng: Oil and Gas Exploitation in China (2018-6-2)

15 Apr 2021

Keywords：采油工程

第2届智能医疗与图像处理国际会议(IMIP 2020)

Conference Date: 23 Apr 2020

Conference Place: 天津

Administered by: IMIP 2020

Improvement in the synthesis of 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(Z)-methoxyiminoacetic acid 2-benzothiazolyl

GAO Shihao, SUN Chenghui, ZHAO Xinqi, GAO Changquan

Frontiers of Chemical Science and Engineering 2008, Volume 2, Issue 1, Pages 80-84 doi: 10.1007/s11705-008-0017-0

Abstract: 2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(Z)-methoxyiminoacetic acid 2-benzothiazolyl thioester(III), an importantintermediate of the fourth generation cephalosporins, was efficiently synthesized by reacting 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(Z)-methoxyiminoacetic acid (I) with 2,2′-dibenzothiazole disulfide (II) in

Keywords： 5-Amino-1 2 4-thiadiazol-3-yl 1 2-dichloroethane important intermediate 2-benzothiazolyl thioester temperature