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FGF23 associated bone diseases

Eryuan Liao

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 65-80 doi: 10.1007/s11684-013-0254-6

Abstract:

Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potentialIn this review, we summarized the FGF superfamily, the mechanism of FGF23 on phosphate and vitamin Dmetabolism, and the FGF23 related bone disease.

Keywords： fibroblast growth factor 23     FGF receptor     phosphate metabolism     Klotho     bone disease    

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Research and Development of Heat-Resistant Materials for Advanced USC Power Plants with Steam Temperatures of 700 °C and Above Review

Fujio Abe

Engineering 2015, Volume 1, Issue 2,   Pages 211-224 doi: 10.15302/J-ENG-2015031

Abstract:

Materials-development projects for advanced ultra-supercritical (A-USC) power plants with steam temperatures of 700 °C and above have been performed in order to achieve high efficiency and low CO2 emissions in Europe, the US, Japan, and recently in China and India as well. These projects involve the replacement of martensitic 9%−12% Cr steels with nickel (Ni)-base alloys for the highest temperature boiler and turbine components in order to provide sufficient creep strength at 700 °C and above. To minimize the require­ment for expensive Ni-base alloys, martensitic 9%−12% Cr steels can be applied to the next highest temperature components of an A-USC power plant, up to a maximum of 650 °C. This paper comprehensively describes the research and development of Ni-base alloys and martensitic 9%−12% Cr steels for thick section boiler and turbine components of A-USC power plants, mainly focusing on the long-term creep-rupture strength of base metal and welded joints, strength loss in welded joints, creep-fatigue properties, and microstructure evolution during exposure at elevated temperatures.

Keywords： strength     creep-fatigue property     welded joint     grain boundary     microstructure     &gamma     &prime     M23C6 carbide    

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pancreatic carcinoma by β-elemene combined with dendritic cells modified with genes encoding interleukin-23

TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 41-45 doi: 10.1007/s11684-007-0008-4

Abstract: The dendritic cell vaccine is a treatment vaccine with potent clinical applications. Functional cytokines can enhance dendritic cell anti-tumor immune responses. This experiment was conducted to study the effects of bone marrow-deriv

Keywords： Functional     experiment     anti-tumor     dendritic     clinical    

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The FGF metabolic axis

Xiaokun Li

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 511-530 doi: 10.1007/s11684-019-0711-y

Abstract: By contrast, FGF19, 21, and 23 coevolve through losing binding affinity for extracellular matrix heparanFGF23 axes from the bone to kidney and parathyroid regulate metabolic homeostasis of phosphate, calciumsignificant divergence in structural elements and multiple functional specifications of FGF19, 21, and 23

Keywords： FGF19     FGF21     FGF23     FGFR     metabolism     endocrine     Klotho    

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The important revelation of “7·23” passenger train accident

Sun Yongfu

Strategic Study of CAE 2012, Volume 14, Issue 12,   Pages 4-9

Abstract:

The process and reasons of “7·23” passenger train

Keywords： passenger train accident     the research and development management     the access management     the emergency response     the railway construction management    

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Artificial intelligence and wireless communications

Wang, Yi-qun Ge, Qi-fan Zhang, Wu-xian Shi,justin.wangjun@huawei.com,lirongone.li@huawei.com,wangjian23

Frontiers of Information Technology & Electronic Engineering 2020, Volume 21, Issue 10,   Pages 1413-1534 doi: 10.1631/FITEE.1900527

Abstract: The applications of (AI) and (ML) technologies in have drawn significant attention recently. AI has demonstrated real success in speech understanding, image identification, and natural language processing domains, thus exhibiting its great potential in solving problems that cannot be easily modeled. AI techniques have become an enabler in to fulfill the increasing and diverse requirements across a large range of application scenarios. In this paper, we elaborate on several typical wireless scenarios, such as channel modeling, channel decoding and signal detection, and channel coding design, in which AI plays an important role in . Then, AI and information theory are discussed from the viewpoint of the information bottleneck. Finally, we discuss some ideas about how AI techniques can be deeply integrated with wireless communication systems.
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High-quality industrial n-type silicon wafers with an efficiency of over 23% for Si heterojunction solar

Fanying MENG,Jinning LIU,Leilei SHEN,Jianhua SHI,Anjun HAN,Liping ZHANG,Yucheng LIU,Jian YU,Junkai ZHANG,Rui ZHOU,Zhengxin LIU

Frontiers in Energy 2017, Volume 11, Issue 1,   Pages 78-84 doi: 10.1007/s11708-016-0435-5

Abstract: the highest efficiency of the SHJ solar cell could be achieved by the wafer with a thickness of 100 µm.Fortunately, over 23% of the conversion efficiency of the SHJ solar cell with a wafer thickness of 100µm was obtained based on the systematic optimization of cell fabrication process in the pilot production

Keywords： n-type Cz-Si     thinner wafer     surface texture     high efficiency     SHJ solar cell    

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Towards Cr(VI)-free anodization of aluminum alloys for aerospace adhesive bonding applications: A review

Abrahami, John M. M. de Kok, Herman Terryn, Johannes M. C. Mol

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 3,   Pages 465-482 doi: 10.1007/s11705-017-1641-3

Abstract: For more than six decades, chromic acid anodizing (CAA) has been the central process in the surface pre-treatment of aluminum for adhesively bonded aircraft structures. Unfortunately, this electrolyte contains hexavalent chromium (Cr(VI)), a compound known for its toxicity and carcinogenic properties. To comply with the new strict international regulations, the Cr(VI)-era will soon have to come to an end. Anodizing aluminum in acid electrolytes produces a self-ordered porous oxide layer. Although different acids can be used to create this type of structure, the excellent adhesion and corrosion resistance that is currently achieved by the complete Cr(VI)-based process is not easily matched. This paper provides a critical overview and appraisal of proposed alternatives to CAA, including combinations of multiple anodizing steps, pre- and post anodizing treatments. The work is presented in terms of the modifications to the oxide properties, such as morphological features (e.g., pore size, barrier layer thickness) and surface chemistry, in order to evaluate the link between fundamental principles of adhesion and bond performance.

Keywords： aluminum     Cr(VI)-free     surface pre-treatments     anodizing     adhesive bonding    

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Scrutiny of non-linear differential equations Euler-Bernoulli beam with large rotational deviation by AGM

M. R. AKBARI,M. NIMAFAR,D. D. GANJI,M. M. AKBARZADE

Frontiers of Mechanical Engineering 2014, Volume 9, Issue 4,   Pages 402-408 doi: 10.1007/s11465-014-0316-8

Abstract:

The kinematic assumptions upon which the Euler-Bernoulli beam theory is founded allow it to be extended to more advanced analysis. Simple superposition allows for three-dimensional transverse loading. Using alternative constitutive equations can allow for viscoelastic or plastic beam deformation. Euler-Bernoulli beam theory can also be extended to the analysis of curved beams, beam buckling, composite beams and geometrically nonlinear beam deflection. In this study, solving the nonlinear differential equation governing the calculation of the large rotation deviation of the beam (or column) has been discussed. Previously to calculate the rotational deviation of the beam, the assumption is made that the angular deviation of the beam is small. By considering the small slope in the linearization of the governing differential equation, the solving is easy. The result of this simplification in some cases will lead to an excessive error. In this paper nonlinear differential equations governing on this system are solved analytically by Akbari-Ganji’s method (AGM). Moreover, in AGM by solving a set of algebraic equations, complicated nonlinear equations can easily be solved and without any mathematical operations such as integration solving. The solution of the problem can be obtained very simply and easily. Furthermore, to enhance the accuracy of the results, the Taylor expansion is not needed in most cases via AGM manner. Also, comparisons are made between AGM and numerical method (Runge-Kutta 4th). The results reveal that this method is very effective and simple, and can be applied for other nonlinear problems.

Keywords： AGM     critical load of columns     large deformations of beam     nonlinear differential equation    

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Enhancing power transfer capability through flexible AC transmission system devices: a review

Fadi M. ALBATSH,Saad MEKHILEF,Shameem AHMAD,H. MOKHLIS,M. A. HASSAN

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 8,   Pages 658-678 doi: 10.1631/FITEE.1500019

Abstract: Global demand for power has significantly increased, but power generation and transmission capacities have not increased proportionally with this demand. As a result, power consumers suffer from various problems, such as voltage and frequency instability and power quality issues. To overcome these problems, the capacity for available power transfer of a transmission network should be enhanced. Researchers worldwide have addressed this issue by using flexible AC transmission system (FACTS) devices. We have conducted a comprehensive review of how FACTS controllers are used to enhance the available transfer capability (ATC) and power transfer capability (PTC) of power system networks. This review includes a discussion of the classification of different FACTS devices according to different factors. The popularity and applications of these devices are discussed together with relevant statistics. The operating principles of six major FACTS devices and their application in increasing ATC and PTC are also presented. Finally, we evaluate the performance of FACTS devices in ATC and PTC improvement with respect to different control algorithms.

Keywords： FACTS devices     Available transfer capability     Power transfer capability     Artificial intelligence    

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Combined heat and power plant integrated with mobilized thermal energy storage (M-TES) system

M, Erik DAHLQUIST

Frontiers in Energy 2010, Volume 4, Issue 4,   Pages 469-474 doi: 10.1007/s11708-010-0123-9

Abstract: The mobilized thermal energy storage (M-TES) system is an alternative source of heat for detached buildingsIn this paper, the integration of a combined heat and power (CHP) plant and an M-TES system is analyzedThe performance of the M-TES system is likewise discussed.

Keywords： Mobilized thermal energy system     district heating     thermal energy storage     combined heat and power     detached houses    

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The Deep Carbon Observatory: A Ten-Year Quest to Study Carbon in Earth

Craig M. Schiffries, Andrea Johnson Mangum, Jennifer L. Mays, Michelle Hoon-Starr, Robert M. Hazen

Engineering 2019, Volume 5, Issue 3,   Pages 372-378 doi: 10.1016/j.eng.2019.03.004

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ThMn12-Type Alloys for Permanent Magnets Review

Hadjipanayis, A.M. Gabay, A.M. Schönhöbel, A. Martín-Cid, J.M. Barandiaran, D. Niarchos

Engineering 2020, Volume 6, Issue 2,   Pages 140-146 doi: 10.1016/j.eng.2018.12.011

Abstract:

Iron-rich compounds with the tetragonal ThMn12-type structure have the potential to meet current demands for rare-earth-lean permanent magnets with high energy density and operating temperatures of 150–200 ℃. However, while it is normal for magnet technology to lag behind the development of underlying magnetic material, this gap has always been unusually large for ThMn12-type magnets. The gap has widened further in recent years, as excellent combinations of intrinsic magnetic properties have been obtained in compounds synthesized with a smaller amount of structure-stabilizing elements (e.g., SmFe11V or Sm0.8Zr0.2Fe9.2Co2.3Ti0.5) or with no such elements (i.e., SmFe9.6Co2.4 thin films). The search for promising compounds continues—with increasing help coming from theoretical calculations. Unfortunately, progress in the development of magnets beyond polymer-bonded interstitially modified powders remains marginal. The introduction of lanthanum (La) was found to stabilize low-meltingtemperature minority phases in Sm(Fe,Ti)12 alloys, thus allowing for liquid-phase sintering for the first time. The high reactivity of La, however, has apparently undermined the development of coercivity (Hc). A controlled crystallization of the initially suppressed ThMn12-type phase makes "bulk" magnetic hardening possible, not only in Sm-Fe-V alloys (in which it has been known since the 1990s), but also is in La-added (Ce,Sm)(Fe,Ti)12 alloys. The properties of the bulk-hardened alloys, however, remain unsatisfactory. Mechanochemically synthesized (Sm,Zr)(Fe,Si)12 and (Sm,Zr)(Fe,Co,Ti)12 powders may become suitable for sintering into powerful fully dense magnets, although not before a higher degree of anisotropy in both alloys and a higher Hc in the latter alloy have been developed.

Keywords： Permanent magnets     Rare earths permanent magnets     ThMn12 structure    

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Velocity gradient elasticity for nonlinear vibration of carbon nanotube resonators

Hamid M. SEDIGHI, Hassen M. OUAKAD

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 6,   Pages 1520-1530 doi: 10.1007/s11709-020-0672-x

Abstract: In this study, for the first time, we investigate the nonlocality superimposed to the size effects on the nonlinear dynamics of an electrically actuated single-walled carbon-nanotube-based resonator. We undertake two models to capture the nanostructure nonlocal size effects: the strain and the velocity gradient theories. We use a reduced-order model based on the differential quadrature method (DQM) to discretize the governing nonlinear equation of motion and acquire a discretized-parameter nonlinear model of the system. The structural nonlinear behavior of the system assuming both strain and velocity gradient theories is investigated using the discretized model. The results suggest that nonlocal and size effects should not be neglected because they improve the prediction of corresponding dynamic amplitudes and, most importantly, the critical resonant frequencies of such nanoresonators. Neglecting these effects may impose a considerable source of error, which can be amended using more accurate modeling techniques.

Keywords： velocity gradient elasticity theory     nanotube resonators     differential-quadrature method     nonlinear vibration    

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RNA m6A modification and its function in diseases

Jiyu Tong, Richard A. Flavell, Hua-Bing Li

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 481-489 doi: 10.1007/s11684-018-0654-8

Abstract:

N6-methyladenosine (m6A) is the most common post-transcriptional RNAmodification throughout the transcriptome, affecting fundamental aspects of RNA metabolism. m6A modification could be installed by m6A “writers” composed of core catalyticThe function of m6A is executed by m6A “readers” that bind to mm6A are still largely unknown.

Keywords： RNA modification     m6A     immunity     cancer     epigenetics    

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Title Author Date Type Operation

FGF23 associated bone diseases

Eryuan Liao

Journal Article

Research and Development of Heat-Resistant Materials for Advanced USC Power Plants with Steam Temperatures of 700 °C and Above

Fujio Abe

Journal Article

pancreatic carcinoma by β-elemene combined with dendritic cells modified with genes encoding interleukin-23

TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo

Journal Article

The FGF metabolic axis

Xiaokun Li

Journal Article

The important revelation of “7·23” passenger train accident

Sun Yongfu

Journal Article

Artificial intelligence and wireless communications

Wang, Yi-qun Ge, Qi-fan Zhang, Wu-xian Shi,justin.wangjun@huawei.com,lirongone.li@huawei.com,wangjian23

Journal Article

High-quality industrial n-type silicon wafers with an efficiency of over 23% for Si heterojunction solar

Fanying MENG,Jinning LIU,Leilei SHEN,Jianhua SHI,Anjun HAN,Liping ZHANG,Yucheng LIU,Jian YU,Junkai ZHANG,Rui ZHOU,Zhengxin LIU

Journal Article

Towards Cr(VI)-free anodization of aluminum alloys for aerospace adhesive bonding applications: A review

Abrahami, John M. M. de Kok, Herman Terryn, Johannes M. C. Mol

Journal Article

Scrutiny of non-linear differential equations Euler-Bernoulli beam with large rotational deviation by AGM

M. R. AKBARI,M. NIMAFAR,D. D. GANJI,M. M. AKBARZADE

Journal Article

Enhancing power transfer capability through flexible AC transmission system devices: a review

Fadi M. ALBATSH,Saad MEKHILEF,Shameem AHMAD,H. MOKHLIS,M. A. HASSAN

Journal Article

Combined heat and power plant integrated with mobilized thermal energy storage (M-TES) system

M, Erik DAHLQUIST

Journal Article

The Deep Carbon Observatory: A Ten-Year Quest to Study Carbon in Earth

Craig M. Schiffries, Andrea Johnson Mangum, Jennifer L. Mays, Michelle Hoon-Starr, Robert M. Hazen

Journal Article

ThMn12-Type Alloys for Permanent Magnets

Hadjipanayis, A.M. Gabay, A.M. Schönhöbel, A. Martín-Cid, J.M. Barandiaran, D. Niarchos

Journal Article

Velocity gradient elasticity for nonlinear vibration of carbon nanotube resonators

Hamid M. SEDIGHI, Hassen M. OUAKAD

Journal Article

RNA m6A modification and its function in diseases

Jiyu Tong, Richard A. Flavell, Hua-Bing Li

Journal Article