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Journal Article 9

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2023 2

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metabolic reprogramming 3

reprogramming 3

pig 2

2-DG 1

CRISPR 1

CTLA-4 1

PD-1 1

PD-L1 1

aerobic glycolysis 1

cancer metabolism 1

cell proliferation 1

combined tumor therapeutic strategies 1

dry eye disease 1

embryonic stem cells 1

genome engineering 1

glycolytic reprogramming 1

iPS cells 1

immune cell 1

immune checkpoint blockade (ICB) 1

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Hyperosmolarity promotes macrophage pyroptosis by driving the glycolytic reprogramming of corneal epithelial

Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 781-795 doi: 10.1007/s11684-023-0986-x

Abstract: this study, the mechanisms involving the hyperosmolar microenvironment, glycolysis mediating metabolic reprogrammingThe hyperosmolar environment was found to greatly induce HCECs’ metabolic reprogramming, which may beIn summary, our findings suggested that hyperosmolar-induced glycolytic reprogramming played an active

Keywords： dry eye disease glycolytic reprogramming pyroptosis inflammation 2-DG

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Oocyte-associated transcription factors in reprogramming after somatic cell nuclear transfer: a review

Fengxia YIN,Hui LIU,Shorgan BOU,Guangpeng LI

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2, Pages 104-113 doi: 10.15302/J-FASE-2014003

Abstract: The reprogramming of the somatic nucleus from its original cellular state to a totipotent state is essentialThe oocyte first obtains its reprogramming capability in the early fetal follicle, and then its capacityis enriched in the late growth phase and reaches its highest capability for reprogramming as fully-grownThe cytoplasmic milieu most likely contains all of the specific transcription and/or reprogramming factorsnecessary for cellular reprogramming.

Keywords： nuclear reprogramming somatic cell transcription factors transcriptomics

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Genome reprogramming for synthetic biology

Kylie Standage-Beier,Xiao Wang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1, Pages 37-45 doi: 10.1007/s11705-017-1618-2

Abstract: The ability to go from a digitized DNA sequence to a predictable biological function is central to synthetic biology. Genome engineering tools facilitate rewriting and implementation of engineered DNA sequences. Recent development of new programmable tools to reengineer genomes has spurred myriad advances in synthetic biology. Tools such as clustered regularly interspace short palindromic repeats enable RNA-guided rational redesign of organisms and implementation of synthetic gene systems. New directed evolution methods generate organisms with radically restructured genomes. These restructured organisms have useful new phenotypes for biotechnology, such as bacteriophage resistance and increased genetic stability. Advanced DNA synthesis and assembly methods have also enabled the construction of fully synthetic organisms, such as J. Craig Venter Institute (JCVI)-syn 3.0. Here we summarize the recent advances in programmable genome engineering tools.

Keywords： CRISPR genome engineering synthetic biology rational design

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transfer and its application in dictating routes of biochemical processes associated with metabolic reprogramming

Frontiers of Medicine 2021, Volume 15, Issue 5, Pages 679-692 doi: 10.1007/s11684-021-0866-1

Abstract: Metabolic reprogramming, such as abnormal utilization of glucose, addiction to glutamine, and increasedis combined with the assumed model of electron balance in a cellular context, the enforced selective reprogrammingEnabling electron transfer could drive metabolic reprogramming in cancer metabolism.

Keywords： metabolic reprogramming potential of electron transfer cell proliferation aerobic glycolysis cancer

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Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

Qijing LEI, Qin PAN, Shuai YU, Na LI, Shulin CHEN, Kuldip SIDHU, Jinlian HUA

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1, Pages 28-32 doi: 10.15302/J-FASE-2018222

Abstract: converted into the pluripotent state by first dedifferentiation to embryonic germ cells and then by reprogrammingThis knowledge will provide some clues which will contribute to the regulation of reprogramming to pluripotency

Keywords： pig pluripotent stem cells primordial germ cells reprogramming

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Immunometabolism: a new dimension in immunotherapy resistance

Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 585-616 doi: 10.1007/s11684-023-1012-z

Abstract: metabolism has long been adjudged as a hallmark of tumor, it is now increasingly accepted that metabolic reprogrammingelaborate potential mechanisms underlying immunotherapy resistance from a novel dimension of metabolic reprogramming

Keywords： immune cell immunometabolism metabolic reprogramming immunotherapy resistance tumor microenvironment

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Induced pluripotent stem cells (IPS): current situation and prospect

Han Weidong,Zhao Yali,Fu Xiaobing

Strategic Study of CAE 2009, Volume 11, Issue 5, Pages 81-87

Abstract: In addition, iPS-cell technology provides novel platforms for research of reprogramming mechanism and

Keywords： somatic cells reprogramming iPS cells

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Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms and strategies

Frontiers of Medicine Pages 805-822 doi: 10.1007/s11684-023-1025-7

Abstract: Recently, numerous studies have revealed that metabolic reprogramming of tumor cells restrains immune

Keywords： CTLA-4 PD-1 PD-L1 immune checkpoint blockade (ICB) metabolic reprogramming combined tumor therapeutic

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Progress, problems and prospects of porcine pluripotent stem cells

Hanning WANG,Yangli PEI,Ning LI,Jianyong HAN

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 1, Pages 6-15 doi: 10.15302/J-FASE-2014009

Abstract: Pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced PSCs (iPSCs), can differentiate into cells of the three germ layers, suggesting that PSCs have great potential for basic developmental biology research and wide applications for clinical medicine. Genuine ESCs and iPSCs have been derived from mice and rats, but not from livestock such as the pig—an ideal animal model for studying human disease and regenerative medicine due to similarities with human physiologic processes. Efforts to derive porcine ESCs and iPSCs have not yielded high-quality PSCs that can produce chimeras with germline transmission. Thus, exploration of the unique porcine gene regulation network of preimplantation embryonic development may permit optimization of culture systems for raising porcine PSCs. Here we summarize the recent progress in porcine PSC generation as well as the problems encountered during this progress and we depict prospects for generating porcine naive PSCs.

Keywords： induced pluripotent stem cells embryonic stem cells pig reprogramming