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Three-dimensional reconstruction of light microscopy image sections: present and future

Yuzhen Wang,Rui Xu,Gaoxing Luo,Jun Wu

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 30-45 doi: 10.1007/s11684-014-0337-z

Abstract:

Three-dimensional (3D) image reconstruction technologies can reveal previously hidden microstructures in human tissue. However, the lack of ideal, non-destructive cross-sectional imaging techniques is still a problem. Despite some drawbacks, histological sectioning remains one of the most powerful methods for accurate high-resolution representation of tissue structures. Computer technologies can produce 3D representations of interesting human tissue and organs that have been serial-sectioned, dyed or stained, imaged, and segmented for 3D visualization. 3D reconstruction also has great potential in the fields of tissue engineering and 3D printing. This article outlines the most common methods for 3D tissue section reconstruction. We describe the most important academic concepts in this field, and provide critical explanations and comparisons. We also note key steps in the reconstruction procedures, and highlight recent progress in the development of new reconstruction methods.

Keywords： microtomy     3D imaging     computer-assisted image processing     3D printing     tissue scaffold    

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Current advances for bone regeneration based on tissue engineering strategies

Rui Shi, Yuelong Huang, Chi Ma, Chengai Wu, Wei Tian

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 160-188 doi: 10.1007/s11684-018-0629-9

Abstract: Bone tissue engineering (BTE) is a rapidly developing strategy for repairing critical-sized bone defects to address the unmet need for bone augmentation and skeletal repair. Effective therapies for bone regeneration primarily require the coordinated combination of innovative scaffolds, seed cells, and biological factors. However, current techniques in bone tissue engineering have not yet reached valid translation into clinical applications because of several limitations, such as weaker osteogenic differentiation, inadequate vascularization of scaffolds, and inefficient growth factor delivery. Therefore, further standardized protocols and innovative measures are required to overcome these shortcomings and facilitate the clinical application of these techniques to enhance bone regeneration. Given the deficiency of comprehensive studies in the development in BTE, our review systematically introduces the new types of biomimetic and bifunctional scaffolds. We describe the cell sources, biology of seed cells, growth factors, vascular development, and the interactions of relevant molecules. Furthermore, we discuss the challenges and perspectives that may propel the direction of future clinical delivery in bone regeneration.

Keywords： bone tissue engineering     stem cell     bone scaffold     growth factor     bone regeneration    

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Current progress on scaffolds of tissue engineering heart valves

DONG Nianguo, SHI Jiawei, CHEN Si, HONG Hao, HU Ping

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 229-234 doi: 10.1007/s11684-008-0043-9

Abstract: It is one of the key factors to select an ideal scaffold material in the construction of TEHV.

Keywords： function     scaffold     promising     research     engineering    

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New branched benign compounds including double antibiotic scaffolds: synthesis, simulation and adsorption for anticorrosion effect on mild steel

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 2,   Pages 167-182 doi: 10.1007/s11705-022-2199-2

Abstract: In this study, two novel environmental benign double antibiotic norfloxacin or ciprofloxacin scaffolds included branched molecules were prepared by multi-step routes and purified by simple performance, which were used as the target compounds (TCs). Meanwhile, a single norfloxacin or ciprofloxacin skeleton based molecules were synthesized as the reference compounds (RCs). The molecular geometry optimization and material simulation computation revealed that TCs presented smaller HOMO-LUMO energy gaps and larger binding energy levels on mild steel surface than RCs. The chemical adsorption of TCs on steel surface was confirmed by X-ray photoelectron spectroscopy, which could be processed by TCs chelation with iron ions. It was shown that TCs could be self-adsorbed on steel surface, which was demonstrated by atomic force microscopy and scanning electron microscopy. The anticorrosion of the studied compounds for mild steel in HCl solution was investigated by electrochemistry analysis. The results suggested that the anticorrosion efficiency could reach 95.86% (TC1) and 97.05% (TC2) at 0.050 mmol·L−1 based on electrochemical impedance spectroscopy, which were much better than RCs (RC1, 69.23%; RC2, 74.16%). The adsorption isotherms of TCs on steel were further fitted, and a deep insight on adsorption was discussed.

Keywords： branched compounds     floxacin scaffold     mild steel     anticorrosion     environmentally benign    

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Cryo-copolymerization preparation of dextran-hyaluronate based supermacroporous cryogel scaffolds for tissue engineering applications

Dongjiao ZHOU, Shaochuan SHEN, Junxian YUN, Kejian YAO, Dong-Qiang LIN

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 3,   Pages 339-347 doi: 10.1007/s11705-012-1209-1

Abstract: observed that the suitable total concentration of macromonomers for the preparation of Dex-HA cryogel scaffoldThe obtained cryogel scaffold with 5% (w/w) macromonomer solution had high water permeability (5.1 ×Furthermore, the cryogel scaffold also had good elastic nature with the elastic modulus of 17.47±1.44The culture of 3T3-L1 preadipocyte within the scaffold was investigated and observed by SEM.Cells clustered on the pore walls and grew inside the scaffold indicating the Dex-HA cryogel scaffold

Keywords： cryogel scaffold     tissue engineering     dextran     hyaluronate     3T3-L1 preadipocyte    

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The Fibrillar Matrix: Novel Avenues for Breast Cancer Detection and Treatment Review

Rasha Rezk,  Raquel Marín-García,  Annica K.B.Gad

Engineering 2021, Volume 7, Issue 10,   Pages 1375-1380 doi: 10.1016/j.eng.2021.04.024

Abstract:

Breast cancer is marked by large increases in the protein fibers around tumor cells. These fibers increase the mechanical stiffness of the tissue, which has long been used for tumor diagnosis by manual palpation. Recent research in bioengineering has led to the development of novel biomaterials that model the mechanical and architectural properties of the tumor microenvironment and can be used to understand how these cues regulate the growth and spread of breast cancer. Herein, we provide an overview of how the mechanical properties of breast tumor tissues differ from those of normal breast tissue and non-cancerous lesions. We also describe how biomaterial models make it possible to understand how the stiffness and viscosity of the extracellular environment regulate cell migration and breast cancer metastasis. We highlight the need for biomaterial models that allow independent analysis of the individual and different mechanical properties of the tumor microenvironment and that use cells derived from different regions within tumors. These models will guide the development of novel mechano-based therapies against breast cancer metastasis.

Keywords： Breast cancer     Tissue stiffness     Cancer metastasis     Cell migration     Bioengineered scaffold     Viscosity    

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Hemocompatible polyurethane/gelatin-heparin nanofibrous scaffolds formed by a bi-layer electrospinning technique as potential artificial blood vessels

Heyun WANG, Yakai FENG, Marc BEHL, Andreas LENDLEIN, Haiyang ZHAO, Ruofang XIAO, Jian LU, Li ZHANG, Jintang GUO

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 3,   Pages 392-400 doi: 10.1007/s11705-011-1202-0

Abstract: In this paper, a scaffold, which mimics the morphology and mechanical properties of a native blood vesselThe scaffold was prepared by sequential bi-layer electrospinning on a rotating mandrel-type collector

Keywords： electrospinning     artificial blood vessels     scaffold     polyurethane     gelatin     nanofiber     hemocompatibility    

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A Review of 3D Printing Technology for Medical Applications Review

Qian Yan,Hanhua Dong,Jin Su,Jianhua Han,Bo Song,Qingsong Wei, Yusheng Shi

Engineering 2018, Volume 4, Issue 5,   Pages 729-742 doi: 10.1016/j.eng.2018.07.021

Abstract:

Donor shortages for organ transplantations are a major clinical challenge worldwide. Potential risks that are inevitably encountered with traditional methods include complications, secondary injuries, and limited source donors. Three-dimensional (3D) printing technology holds the potential to solve these limitations; it can be used to rapidly manufacture personalized tissue engineering scaffolds, repair tissue defects in situ with cells, and even directly print tissue and organs. Such printed implants and organs not only perfectly match the patient’s damaged tissue, but can also have engineered material microstructures and cell arrangements to promote cell growth and differentiation. Thus, such implants allow the desired tissue repair to be achieved, and could eventually solve the donor-shortage problem. This review summarizes relevant studies and recent progress on four levels, introduces different types of biomedical materials, and discusses existing problems and development issues with 3D printing that are related to materials and to the construction of extracellular matrix in vitro for medical applications.

Keywords： 3D printing     Implant     Scaffold     Biomedical material    

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Effect of incorporating Elaeagnus angustifolia extract in PCL-PEG-PCL nanofibers for bone tissue engineering

Vahideh R. Hokmabad, Soodabeh Davaran, Marziyeh Aghazadeh, Effat Alizadeh, Roya Salehi, Ali Ramazani

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 1,   Pages 108-119 doi: 10.1007/s11705-018-1742-7

Abstract:

Plants have been used for medicinal purposes for thousands of years but they are still finding new uses in modern times. For example, Elaeagnus angustifolia (EA) is a medicinal herb with antinociceptive, anti-inflammatory, antibacterial and antioxidant properties and it is widely used in the treatment of rheumatoid arthritis and osteoarthritis. EA extract was loaded onto poly(ϵ-caprolactone)-poly(ethylene glycol)-poly(ϵ-caprolactone) (PCL-PEG-PCL/EA) nanofibers and their potential applications for bone tissue engineering were studied. The morphology and chemical properties of the fibers were evaluated using Fourier transform infrared spectroscopy, field emission scanning electron microscopy, contact angle measurements and mechanical tests. All the samples had bead-free morphologies with average diameters ranging from 100 to 200 nm. The response of human cells to the PCL-PEG-PCL/EA nanofibers was evaluated using human dental pulp stem cells (hDPSCs). The hDPSCs had better adhesion and proliferation capacity on the EA loaded nanofibers than on the pristine PCL-PEG-PCL nanofibers. An alizarin red S assay and the alkaline phosphatase activity confirmed that the nanofibrous scaffolds induced osteoblastic performance in the hDPSCs. The quantitative real time polymerase chain reaction results confirmed that the EA loaded nanofibrous scaffolds had significantly upregulated gene expression correlating to osteogenic differentiation. These results suggest that PCL-PEG-PCL/EA nanofibers might have potential applications for bone tissue engineering.

Keywords： Elaeagnus angustifolia     scaffold     electrospinning     human dental pulp stem cell     tissue engineering    

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A Review on the 3D Printing of Functional Structures for Medical Phantoms and Regenerated Tissue and Organ Applications

Kan Wang, Chia-Che Ho, Chuck Zhang, Ben Wang

Engineering 2017, Volume 3, Issue 5,   Pages 653-662 doi: 10.1016/J.ENG.2017.05.013

Abstract:

Medical models, or “phantoms,” have been widely used for medical training and for doctor-patient interactions. They are increasingly used for surgical planning, medical computational models, algorithm verification and validation, and medical devices development. Such new applications demand high-fidelity, patient-specific, tissue-mimicking medical phantoms that can not only closely emulate the geometric structures of human organs, but also possess the properties and functions of the organ structure. With the rapid advancement of three-dimensional (3D) printing and 3D bioprinting technologies, many researchers have explored the use of these additive manufacturing techniques to fabricate functional medical phantoms for various applications. This paper reviews the applications of these 3D printing and 3D bioprinting technologies for the fabrication of functional medical phantoms and bio-structures. This review specifically discusses the state of the art along with new developments and trends in 3D printed functional medical phantoms (i.e., tissue-mimicking medical phantoms, radiologically relevant medical phantoms, and physiological medical phantoms) and 3D bio-printed structures (i.e., hybrid scaffolding materials, convertible scaffolds, and integrated sensors) for regenerated tissues and organs.

Keywords： 3D printing     3D bioprinting     Medical phantom     Regenerated tissue/organ     Scaffold    

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Effects of Three-Dimensional Platform Stiffness and Layer Dimensions on Separation of Carcinoma Cells Article

W.G. Zhang, Z.Y. Liu, S.W. Pang

Engineering 2021, Volume 7, Issue 10,   Pages 1426-1435 doi: 10.1016/j.eng.2020.09.010

Abstract: In this work, three-dimensional (3D) biomimetic scaffold platforms were developed to separate nasopharyngealThe migration characteristics of NPC43 and NP460 cells on the scaffold platforms revealed that NPC43platforms, 89% separation efficiency of NPC43 cells from NP460 cells was achieved on stiffer two-layer scaffold

Keywords： Cell separation     Cell migration     Nasopharyngeal carcinoma (NPC)     3D scaffold platform    

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One-Step Preparation of Green Fabric for Continuous Antibacterial Applications Article

Rongkang Huang, Minghui Hu, Weiwen Liang, Juanjuan Zheng, Yang Du, Yanhuan Lin, Huaiming Wang, Wentai Guo, Zhantao Zeng, Chuangkun Li, Ming Li, Hui Wang, Xingcai Zhang

Engineering 2021, Volume 7, Issue 3,   Pages 326-333 doi: 10.1016/j.eng.2020.08.022

Abstract: triclosan can effectively interact with dopamine during biocompatible polydopamine formation on the PP scaffoldof triclosan from the biocompatible polydopamine coating, a 5 mm × 5 mm sample of TPP-coated scaffold

Keywords： Green chemistry     Polypropylene scaffold     Polydopamine     Triclosan     Antibacterial    

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Title Author Date Type Operation

Three-dimensional reconstruction of light microscopy image sections: present and future

Yuzhen Wang,Rui Xu,Gaoxing Luo,Jun Wu

Journal Article

Current advances for bone regeneration based on tissue engineering strategies

Rui Shi, Yuelong Huang, Chi Ma, Chengai Wu, Wei Tian

Journal Article

Current progress on scaffolds of tissue engineering heart valves

DONG Nianguo, SHI Jiawei, CHEN Si, HONG Hao, HU Ping

Journal Article

New branched benign compounds including double antibiotic scaffolds: synthesis, simulation and adsorption for anticorrosion effect on mild steel

Journal Article

Cryo-copolymerization preparation of dextran-hyaluronate based supermacroporous cryogel scaffolds for tissue engineering applications

Dongjiao ZHOU, Shaochuan SHEN, Junxian YUN, Kejian YAO, Dong-Qiang LIN

Journal Article

The Fibrillar Matrix: Novel Avenues for Breast Cancer Detection and Treatment

Rasha Rezk,  Raquel Marín-García,  Annica K.B.Gad

Journal Article

Hemocompatible polyurethane/gelatin-heparin nanofibrous scaffolds formed by a bi-layer electrospinning technique as potential artificial blood vessels

Heyun WANG, Yakai FENG, Marc BEHL, Andreas LENDLEIN, Haiyang ZHAO, Ruofang XIAO, Jian LU, Li ZHANG, Jintang GUO

Journal Article

A Review of 3D Printing Technology for Medical Applications

Qian Yan,Hanhua Dong,Jin Su,Jianhua Han,Bo Song,Qingsong Wei, Yusheng Shi

Journal Article

Effect of incorporating Elaeagnus angustifolia extract in PCL-PEG-PCL nanofibers for bone tissue engineering

Vahideh R. Hokmabad, Soodabeh Davaran, Marziyeh Aghazadeh, Effat Alizadeh, Roya Salehi, Ali Ramazani

Journal Article

A Review on the 3D Printing of Functional Structures for Medical Phantoms and Regenerated Tissue and Organ Applications

Kan Wang, Chia-Che Ho, Chuck Zhang, Ben Wang

Journal Article

Effects of Three-Dimensional Platform Stiffness and Layer Dimensions on Separation of Carcinoma Cells

W.G. Zhang, Z.Y. Liu, S.W. Pang

Journal Article

One-Step Preparation of Green Fabric for Continuous Antibacterial Applications

Rongkang Huang, Minghui Hu, Weiwen Liang, Juanjuan Zheng, Yang Du, Yanhuan Lin, Huaiming Wang, Wentai Guo, Zhantao Zeng, Chuangkun Li, Ming Li, Hui Wang, Xingcai Zhang

Journal Article