Resource Type

Journal Article 12

Year

2021 1

2016 1

2014 1

2011 3

2010 3

2009 2

2007 1

open ︾

Keywords

signal transduction 6

CD14 1

DNA damage 1

Zhihuang decoction 1

abdominal aorta coarctation 1

alcohol 1

ataxia-telangiectasia mutated (ATM) 1

bradykinin 1

cell adhesion 1

cell cycle checkpoint 1

chinensis 1

disease 1

drug target 1

electrical signal / glutamate receptor-like / herbivory / jasmonic acid / tomato 1

environmental 1

feedback 1

gastric carcinoma 1

gene chips 1

generation 1

inhibitor 1

open ︾

Search scope:

排序： Display mode:

CHARACTERISTICS OF HERBIVORY/WOUND-ELICITED ELECTRICAL SIGNAL TRANSDUCTION IN TOMATO

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract: The transduction of wound-elicited electrical signals in the model plant species Arabidopsis has been characterized but the characteristics of electrical signal transduction in responseLeaflet wounding also activated electrical signal transduction and jasmonic acid (JA) signaling withinThis work reveals the nature of electrical signal transduction in tomato and emphasizes the key rolesof GLR3.3 and GLR3.5 in electrical signal transduction and JA signaling activation.

Keywords： electrical signal / glutamate receptor-like / herbivory / jasmonic acid / tomato    

HTML PDF Collect

Effect of decoction on CD14 expression in lipopolysaccharide signal transduction pathway of alcohol-induced

Rui ZHU MD , Lin SHEN MD , Jianguo LIU MD , Weili ZHANG MM , Ling YANG MD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 363-367 doi: 10.1007/s11684-009-0064-z

Abstract: investigate the effects of (枳黄) decoction on CD14 expression in the lipopolysaccharide signal transductiondecoction can significantly reduce CD14 expression in the lipopolysaccharide signal transduction pathway

Keywords： liver disease     alcohol     Zhihuang decoction     CD14     signal transduction    

HTML PDF Collect

The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 70-76 doi: 10.1007/s11684-011-0119-9

Abstract: could regulate distinct aspects of neural signal transduction and suggest that the coordinated actions

Keywords： signal transduction     neurogenic disease    

HTML PDF Collect

bradykinin on bradykinin-B2 receptor in rat aortic vascular smooth muscle cells and the involved signal transduction

Wen YAN MD, Min FENG MD, Pei-Hua WANG MD, Dao-Wen WANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 225-228 doi: 10.1007/s11684-010-0003-z

Abstract: study the effect of bradykinin (BK) on bradykinin-B2 receptor as well as the possible involved signal transductionPD98059, Akt inhibitor, and LY294002 inhibited up-regulation of B2 receptor induced by BK. (3) Signal transduction

Keywords： bradykinin     vascular smooth muscle cells     signal transduction pathways    

HTML PDF Collect

Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition

Jiansong Huang,Yulan Zhou,Xiaoyu Su,Yuanjing Lyu,Lanlan Tao,Xiaofeng Shi,Ping Liu,Zhangbiao Long,Zheng Ruan,Bing Xiao,Wenda Xi,Quansheng Zhou,Jianhua Mao,Xiaodong Xi

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 311-319 doi: 10.1007/s11684-016-0460-0

Abstract:

We evaluated the roles of calpain cleavage-related mutations of the integrin β3 cytoplasmic tail in integrin αIIbβ3 bidirectional signaling using a trans-dominant inhibition model. Chimeric Tac-β3 proteins (i.e., Tac-β3, Tac-β3D741, Tac-β3D747, Tac-β3D754, Tac-β3D759, and Tac-β3DNITY) consisting of the extracellular and transmembrane domains of human IL-2 receptor (Tac) and the human integrin β3 cytoplasmic domain were stably expressed in the 123 CHO cells harboring human glycoprotein Ib-IX and wild-type integrin αIIbβ3. The different cells were assayed for stable adhesion and spreading on immobilized fibrinogen, and for binding soluble fibrinogen representing outside-in and inside-out signaling events, respectively. The chimeric protein Tac-β3 inhibited, and Tac-β3DNITY partially attenuated stable adhesion and spreading. Tac-β3, Tac-β3D759, Tac-β3DNITY, and Tac-β3D754, but not Tac-β3D747 or Tac-β3D741, impaired the soluble fibrinogen binding. Results indicated that the bidirectional signaling was significantly inhibited by Tac-β3 and Tac-β3DNITY, albeit to a much lesser extent. Moreover, only inside-out signaling was impaired in the 123/Tac-β3D759 and 123/Tac-β3D754 cells in contrast to an intact bidirectional signaling in the 123/Tac-β3D747 and 123/Tac-β3D741 cells. In conclusion, the calpain cleavage of integrin β3 resulted in the regulatory effects on signaling by interrupting its interaction with cytoplasmic proteins rather than altering its conformation, and may thus regulate platelet function.

Keywords： integrin β3     signal transduction     trans-dominant inhibition model    

HTML PDF Collect

Regulatory factors of mesenchymal stem cell migration into injured tissues and their signal transduction

Li LI, Jianxin JIANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 33-39 doi: 10.1007/s11684-011-0114-1

Abstract: This review will briefly summarize the regulatory facors and signaling transduction pathways involved

Keywords： mesenchymal stem cells     migration     molecular mechanisms     signaling pathway    

HTML PDF Collect

Talin and kindlin: the one-two punch in integrin activation

Feng Ye, Adam K. Snider, Mark H. Ginsberg

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 6-16 doi: 10.1007/s11684-014-0317-3

Abstract:

Proper cell-cell and cell-matrix contacts mediated by integrin adhesion receptors are important for development, immune response, hemostasis and wound healing. Integrins pass trans-membrane signals bidirectionally through their regulated affinities for extracellular ligands and intracellular signaling molecules. Such bidirectional signaling by integrins is enabled by the conformational changes that are often linked among extracellular, transmembrane and cytoplasmic domains. Here, we review how talin-integrin and kindlin-integrin interactions, in cooperation with talin-lipid and kindlin-lipid interactions, regulate integrin affinities and how the progress in these areas helps us understand integrin-related diseases.

Keywords： signal transduction     transmembrane domain     nanodisc     integrin     talin     kindling     cell adhesion    

HTML PDF Collect

Protective effect of tanshinone II A on signal transduction system protein kinase B in rats with myocardial

Enyuan TU MD, Yongjun PAN MM, Kang ZHENG MM, Zhaohua WANG MD, Qiansheng LIANG MD, Guangtian YANG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 431-436 doi: 10.1007/s11684-009-0088-4

Abstract: The effects of tanshinone II A on cell signal transduction system protein kinase B in rats with myocardial

Keywords： tanshinone II A     myocardial hypertrophy     rat     protein kinase B     abdominal aorta coarctation    

HTML PDF Collect

Functional role of ATM in the cellular response to DNA damage

Ming LIU, Wenxiang HU

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 2,   Pages 179-187 doi: 10.1007/s11705-009-0268-4

Abstract: Ataxia-telangiectasia mutated (ATM) plays a key role in regulating the cellular response to ionizing radiation. The tumor-suppressor gene ATM, mutations in which cause the human genetic disease ataxia telangiectasia, encodes a key protein kinase that controls the cellular response to double-stranded breaks. Activation of ATM results in phosphorylation of many downstream targets that modulate numerous damage response pathways, most notably cell cycle checkpoints. Here, we highlight some of the new developments in the field in our understanding of the mechanism of activation of ATM and its signaling pathways, explore whether DNA double-strand breaks are the sole activators of ATM and ATM-dependent signaling pathways, and address some of the prominent, unanswered questions related to ATM and its function. The scope of this article is to provide a brief overview of the recent literature on this subject and to raise questions that could be addressed in future studies.

Keywords： ataxia-telangiectasia mutated (ATM)     cell cycle checkpoint     DNA damage     signalling transduction    

HTML PDF Collect

Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?

Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 46-53 doi: 10.1007/s11684-010-0010-0

Abstract: Mitogen-activated protein kinase (MAPK) signaling pathway, one of the most important signaling pathways in eukaryotic organism, is involved in multiple cellular events such as cell growth, differentiation, and apoptosis. MAPK is of great importance to the normal function of organisms, while its dysfunction results in various diseases. So far, inhibitors specifically against each subfamilies of MAP kinase have been developed, while more endeavors are needed to discover the compounds selectively targeting a particular subfamily member. Most of the kinase inhibitors exert their functions in an ATP-competitive way or a non-ATP-competitive way. Further studies on the effective mechanism of the MAPK inhibitors and their therapeutic roles in the treatment of diseases are helpful for the illumination of MAP kinase function, the development of novel inhibitors, and the therapy of diseases caused by the dysfunction of the MAPK pathway.

Keywords： mitogen-activated protein kinase     drug target     inhibitor     signal transduction     disease    

HTML PDF Collect

Neural networks modeling signal responses and taxol production of cultured Taxus chinensis cells induced by bio-elicitor

GONG Yanwen, REN Defeng, YUAN Yingjin

Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 2,   Pages 118-122 doi: 10.1007/s11705-007-0022-8

Abstract: Quantitatively describing the signal transduction process is important for understanding the mechanism

Keywords： transduction     chinensis     feedback     environmental     generation    

HTML PDF Collect

Data mining of microarray for differentially expressed genes in liver metastasis from gastric cancer

Ling XU MM, Feng WANG MM, Xuan-Fu XU MD, Wen-Hui MO BM, Rong WAN MD, Chuan-Yong GUO MD, Xing-Peng WANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 247-253 doi: 10.1007/s11684-010-0027-4

Abstract: In order to find metastasis-related genes and abnormal signal transduction pathway of high-invasive gastricWe conclude that data mining allows to quickly identify a series of special signal transduction pathways

Keywords： gastric carcinoma     metastasis     signal transduction     gene chips    

HTML PDF Collect

Title Author Date Type Operation

CHARACTERISTICS OF HERBIVORY/WOUND-ELICITED ELECTRICAL SIGNAL TRANSDUCTION IN TOMATO

Journal Article

Effect of decoction on CD14 expression in lipopolysaccharide signal transduction pathway of alcohol-induced

Rui ZHU MD , Lin SHEN MD , Jianguo LIU MD , Weili ZHANG MM , Ling YANG MD ,

Journal Article

The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

Yuan CHEN, Qi TIAN

Journal Article

bradykinin on bradykinin-B2 receptor in rat aortic vascular smooth muscle cells and the involved signal transduction

Wen YAN MD, Min FENG MD, Pei-Hua WANG MD, Dao-Wen WANG MD,

Journal Article

Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition

Jiansong Huang,Yulan Zhou,Xiaoyu Su,Yuanjing Lyu,Lanlan Tao,Xiaofeng Shi,Ping Liu,Zhangbiao Long,Zheng Ruan,Bing Xiao,Wenda Xi,Quansheng Zhou,Jianhua Mao,Xiaodong Xi

Journal Article

Regulatory factors of mesenchymal stem cell migration into injured tissues and their signal transduction

Li LI, Jianxin JIANG

Journal Article

Talin and kindlin: the one-two punch in integrin activation

Feng Ye, Adam K. Snider, Mark H. Ginsberg

Journal Article

Protective effect of tanshinone II A on signal transduction system protein kinase B in rats with myocardial

Enyuan TU MD, Yongjun PAN MM, Kang ZHENG MM, Zhaohua WANG MD, Qiansheng LIANG MD, Guangtian YANG MD,

Journal Article

Functional role of ATM in the cellular response to DNA damage

Ming LIU, Wenxiang HU

Journal Article

Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?

Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,

Journal Article

Neural networks modeling signal responses and taxol production of cultured Taxus chinensis cells induced by bio-elicitor

GONG Yanwen, REN Defeng, YUAN Yingjin

Journal Article

Data mining of microarray for differentially expressed genes in liver metastasis from gastric cancer

Ling XU MM, Feng WANG MM, Xuan-Fu XU MD, Wen-Hui MO BM, Rong WAN MD, Chuan-Yong GUO MD, Xing-Peng WANG MD,

Journal Article