检索范围:
排序: 展示方式:
Nan Qin, Guang Xu, Yan Wang, Xiaoyan Zhan, Yuan Gao, Zhilei Wang, Shubin Fu, Wei Shi, Xiaorong Hou, Chunyu Wang, Ruisheng Li, Yan Liu, Jiabo Wang, Haiping Zhao, Xiaohe Xiao, Zhaofang Bai
《医学前沿(英文)》 2021年 第15卷 第4期 页码 594-607 doi: 10.1007/s11684-020-0809-2
关键词: Psoraleae Fructus bavachin idiosyncratic drug-induced liver injury caspase-1 IL-1β NLRP3 inflammasome
null
《医学前沿(英文)》 2014年 第8卷 第2期 页码 217-226 doi: 10.1007/s11684-014-0326-2
This study was designed to investigate the contribution of miRNA-122-binding site polymorphism at the IL-1A gene and its multiplicative interactions with hepatitis B virus (HBV) mutations in the risk of hepatocellular carcinoma (HCC). A total of 1021 healthy controls, 302 HBV surface antigen (HBsAg) seroclearance subjects, and 2011 HBsAg-positive subjects (including 1021 HCC patients) were enrolled in this study. Quantitative PCR was used to genotype rs3783553. HBV mutations were determined by direct sequencing. Multivariate logistic regression analyses were performed to test the associations of rs3783553, mutations, and their interactions with the risk of HCC. No significant association was found between rs3783553 and the risk of HCC among healthy controls, HBsAg seroclearance subjects, HBsAg-positive subjects without HCC, and all controls. Additionally, rs3783553 was not significantly associated with chronic HBV infection, liver cirrhosis, HBV e antigen seroconversion, abnormal alanine aminotransferase, and high viral load (>104 copies/ml). However, the TTCA insertion allele of rs3783553 was significantly associated with an increased frequency of HBV C7A mutation compared with homozygous TTCA deletion carriers [(del/ins+ ins/ins) vs. del/del, adjusted odds ratio (OR)=1.48, 95% confidence interval (CI)=1.09-2.02, P=0.013]. Multiplicative interaction of rs3783553 with HBV preS deletion significantly reduced the risk of HCC in males, with an adjusted OR of 0.64 (95% CI=0.42-0.98; P=0.041) after age and HBV genotype were adjusted. Although rs3783553 did not significantly affect genetic susceptibility to HBV-related HCC, its variant allele may predispose the host to selecting HBV C7A mutation during evolution and significantly reduce the risk of HCC caused by HBV preS deletion. This study provides an insight into the complex host-virus interaction in HBV-induced hepatocarcinogenesis and is helpful in determining HBsAg-positive subjects who are likely to develop HCC.
关键词: hepatocellular carcinoma (HCC) interaction miRNA-122-binding site IL-1A rs3783553 hepatitis B virus (HBV) mutations
《医学前沿(英文)》 2022年 第16卷 第6期 页码 909-918 doi: 10.1007/s11684-021-0890-1
关键词: acute promyelocytic leukemia intracranial hemorrhage cytokines biomarker
Effect of IL-10 on formation of foam cell induced by ox-LDL
WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng
《医学前沿(英文)》 2008年 第2卷 第3期 页码 298-302 doi: 10.1007/s11684-008-0057-3
关键词: inflammatory presence interleukin-10 dose-dependent ox-LDL
Emergence in cyber-physical systems: potential and risk
Shmuel Tyszberowicz, David Faitelson,tyshbe@tau.ac.il,davidf@afeka.ac.il
《信息与电子工程前沿(英文)》 2020年 第21卷 第11期 页码 1535-1670 doi: 10.1631/FITEE.2000279
Decomposition of aqueous chlorinated contaminants by UV irradiation with H
Eunsung KAN,Chang-Il KOH,Kyunghyuk LEE,Joonwun KANG
《环境科学与工程前沿(英文)》 2015年 第9卷 第3期 页码 429-435 doi: 10.1007/s11783-014-0677-6
关键词: H2O2/ultraviolet (UV) light advanced oxidation UV light irradiation chlorinated contaminants photochemical treatment characteristics
铰接车辆的主动转向控制策略研究 Article
Kyong-il KIM,Hsin GUAN,Bo WANG,Rui GUO,Fan LIANG
《信息与电子工程前沿(英文)》 2016年 第17卷 第6期 页码 576-586 doi: 10.1631/FITEE.1500211
Cytokine storm and translating IL-6 biology into effective treatments for COVID-19
《医学前沿(英文)》 doi: 10.1007/s11684-023-1044-4
关键词: SARS-CoV-2 COVID-19 cytokine storm interleukin-6 tocilizumab
Effects of heavy rainfall on the composition of airborne bacterial communities
Gwang Il Jang, Chung Yeon Hwang, Byung Cheol Cho
《环境科学与工程前沿(英文)》 2018年 第12卷 第2期 doi: 10.1007/s11783-018-1008-0
关键词: Aerosol Bacteria Community composition Pyrosequencing Rain
Jinyoung YOON; Byoung Il CHOI; Jae Hong KIM
《结构与土木工程前沿(英文)》 2022年 第16卷 第4期 页码 506-514 doi: 10.1007/s11709-022-0813-5
关键词: adsorption polycarboxylate superplasticizer rheology dispersion
采用背景人声简化特征集的说话人识别直方图均衡化方法 Article
Myung-jae KIM, Il-ho YANG, Min-seok KIM, Ha-jin YU
《信息与电子工程前沿(英文)》 2017年 第18卷 第5期 页码 738-750 doi: 10.1631/FITEE.1500380
Th17 Cells in autoimmune diseases
null
《医学前沿(英文)》 2015年 第9卷 第1期 页码 10-19 doi: 10.1007/s11684-015-0388-9
Th17 cells are a new subset of CD4+ T cells involved in the clearance of extracellular pathogens and fungi. Accumulating evidence suggests that Th17 cells and their signature cytokines have a pivotal role in the pathogenesis of multiple autoimmune-mediated inflammatory diseases. Here, we summarize recent research progress on Th17 function in the development and pathogenesis of autoimmune diseases. We also propose to identify new small molecule compounds to manipulate Th17 function for potential therapeutic application to treat human autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sj?gren’s syndrome, inflammatory bowel disease, and multiple sclerosis.
关键词: IL-17 Th17 cells RORγt autoimmune diseases posttranslational modification inhibitors
灰色预测模型GM(1,1)的适用性分析及在火灾风险预测中的应用
陈子锦,王福亮,陆守香
《中国工程科学》 2007年 第9卷 第5期 页码 91-94
通过对灰色预测模型———GM(1,1)的理论分析,证明了该模型的预测值及其变化趋势均具有单调 性,进而提出了GM(1,1)模型的适用性判据,并给出了该判据在火灾风险灰色预测中的应用实例。
《医学前沿(英文)》 页码 805-822 doi: 10.1007/s11684-023-1025-7
关键词: CTLA-4 PD-1 PD-L1 immune checkpoint blockade (ICB) metabolic reprogramming combined tumor therapeutic strategies
邓运华
《中国工程科学》 2011年 第13卷 第10期 页码 13-18
标题 作者 时间 类型 操作
Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity
Nan Qin, Guang Xu, Yan Wang, Xiaoyan Zhan, Yuan Gao, Zhilei Wang, Shubin Fu, Wei Shi, Xiaorong Hou, Chunyu Wang, Ruisheng Li, Yan Liu, Jiabo Wang, Haiping Zhao, Xiaohe Xiao, Zhaofang Bai
期刊论文
Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with
null
期刊论文
Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic
期刊论文
Effect of IL-10 on formation of foam cell induced by ox-LDL
WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng
期刊论文
Emergence in cyber-physical systems: potential and risk
Shmuel Tyszberowicz, David Faitelson,tyshbe@tau.ac.il,davidf@afeka.ac.il
期刊论文
Decomposition of aqueous chlorinated contaminants by UV irradiation with H
Eunsung KAN,Chang-Il KOH,Kyunghyuk LEE,Joonwun KANG
期刊论文
Effects of heavy rainfall on the composition of airborne bacterial communities
Gwang Il Jang, Chung Yeon Hwang, Byung Cheol Cho
期刊论文
Adsorption properties of polycarboxylate ether-based superplasticizer on cement particles and their resultant dispersion
Jinyoung YOON; Byoung Il CHOI; Jae Hong KIM
期刊论文
Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms
期刊论文