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Expression of integrin in hepatic fibrosis and intervention of resveratrol
Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN
《医学前沿(英文)》 2009年 第3卷 第1期 页码 100-107 doi: 10.1007/s11684-009-0013-x
关键词: liver fibrosis integrin-β1 resveratrol tumor growth factor-β tissue inhibitor of metalloproteinase-1
null
《医学前沿(英文)》 2016年 第10卷 第3期 页码 311-319 doi: 10.1007/s11684-016-0460-0
We evaluated the roles of calpain cleavage-related mutations of the integrin β3 cytoplasmic tail in integrin αIIbβ3 bidirectional signaling using a trans-dominant inhibition model. Chimeric Tac-β3 proteins (i.e., Tac-β3, Tac-β3D741, Tac-β3D747, Tac-β3D754, Tac-β3D759, and Tac-β3DNITY) consisting of the extracellular and transmembrane domains of human IL-2 receptor (Tac) and the human integrin β3 cytoplasmic domain were stably expressed in the 123 CHO cells harboring human glycoprotein Ib-IX and wild-type integrin αIIbβ3. The different cells were assayed for stable adhesion and spreading on immobilized fibrinogen, and for binding soluble fibrinogen representing outside-in and inside-out signaling events, respectively. The chimeric protein Tac-β3 inhibited, and Tac-β3DNITY partially attenuated stable adhesion and spreading. Tac-β3, Tac-β3D759, Tac-β3DNITY, and Tac-β3D754, but not Tac-β3D747 or Tac-β3D741, impaired the soluble fibrinogen binding. Results indicated that the bidirectional signaling was significantly inhibited by Tac-β3 and Tac-β3DNITY, albeit to a much lesser extent. Moreover, only inside-out signaling was impaired in the 123/Tac-β3D759 and 123/Tac-β3D754 cells in contrast to an intact bidirectional signaling in the 123/Tac-β3D747 and 123/Tac-β3D741 cells. In conclusion, the calpain cleavage of integrin β3 resulted in the regulatory effects on signaling by interrupting its interaction with cytoplasmic proteins rather than altering its conformation, and may thus regulate platelet function.
关键词: integrin β3 signal transduction trans-dominant inhibition model
Talin and kindlin: the one-two punch in integrin activation
null
《医学前沿(英文)》 2014年 第8卷 第1期 页码 6-16 doi: 10.1007/s11684-014-0317-3
Proper cell-cell and cell-matrix contacts mediated by integrin adhesion receptors are important for development, immune response, hemostasis and wound healing. Integrins pass trans-membrane signals bidirectionally through their regulated affinities for extracellular ligands and intracellular signaling molecules. Such bidirectional signaling by integrins is enabled by the conformational changes that are often linked among extracellular, transmembrane and cytoplasmic domains. Here, we review how talin-integrin and kindlin-integrin interactions, in cooperation with talin-lipid and kindlin-lipid interactions, regulate integrin affinities and how the progress in these areas helps us understand integrin-related diseases.
关键词: signal transduction transmembrane domain nanodisc integrin talin kindling cell adhesion
Coronary leukocyte activation in relation to progression of coronary artery disease
null
《医学前沿(英文)》 2016年 第10卷 第1期 页码 85-90 doi: 10.1007/s11684-016-0435-1
Leukocyte activation has been linked to atherogenesis, but there is little in vivo evidence for its role in the progression of atherosclerosis. We evaluated the predictive value for progression of coronary artery disease (CAD) of leukocyte activation markers in the coronary circulation. Monocyte and neutrophil CD11b, neutrophil CD66b expression and intracellular neutrophil myeloperoxidase (MPO) in the coronary arteries were determined by flow cytometry in patients undergoing coronary angiography. The primary outcome included fatal and nonfatal myocardial infarction or arterial vascular intervention due to unstable angina pectoris. In total 99 subjects who were included, 70 had CAD at inclusion (26 patients had single-vessel disease, 18 patients had two-vessel disease and 26 patients had three-vessel disease). The median follow-up duration was 2242 days (interquartile range: 2142–2358). During follow-up, 13 patients (13%) developed progression of CAD. Monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO measured in blood obtained from the coronary arteries were not associated with the progression of CAD. These data indicate that coronary monocyte CD11b, neutrophil CD11b and CD66b expression and intracellular MPO do not predict the risk of progression of CAD.
关键词: coronary artery disease inflammation integrin myeloperoxidase leukocyte activation
灰色预测模型GM(1,1)的适用性分析及在火灾风险预测中的应用
陈子锦,王福亮,陆守香
《中国工程科学》 2007年 第9卷 第5期 页码 91-94
通过对灰色预测模型———GM(1,1)的理论分析,证明了该模型的预测值及其变化趋势均具有单调 性,进而提出了GM(1,1)模型的适用性判据,并给出了该判据在火灾风险灰色预测中的应用实例。
《医学前沿(英文)》 页码 805-822 doi: 10.1007/s11684-023-1025-7
关键词: CTLA-4 PD-1 PD-L1 immune checkpoint blockade (ICB) metabolic reprogramming combined tumor therapeutic strategies
邓运华
《中国工程科学》 2011年 第13卷 第10期 页码 13-18
联邦无监督表示学习 Research Article
张凤达1,况琨1,陈隆1,游兆阳1,沈弢1,肖俊1,张寅1,吴超2,吴飞1,庄越挺1,李晓林3,4,5
《信息与电子工程前沿(英文)》 2023年 第24卷 第8期 页码 1181-1193 doi: 10.1631/FITEE.2200268
关键词: 联邦学习;无监督学习;表示学习;对比学习
王正新,党耀国,刘思峰
《中国工程科学》 2012年 第14卷 第7期 页码 98-102
针对工程中大量存在的非等间距序列的建模问题,提出了非等间距GM(1, 1)幂模型。以平均相对误差绝对值最小化为目标,以模型参数之间的关系为约束,构建了一个非线性优化模型实现非等间距GM(1, 1)幂模型的参数估计。结果表明,非等间距GM(1, 1)幂模型的形式较为灵活,非等间距GM(1, 1)模型和灰色Verhulst模型均是非等间距GM(1, 1)幂模型的特殊情形,幂指数的优化有利于提高建模精度。最后通过一个工程实例验证了非等间距GM(1, 1)幂模型的有效性与实用性。
磁控溅射法生长的带隙可调谐(GaxIn1−x)2O3 Research Articles
张法碧1,孙巾寓1,李海鸥1,周娟1,王荣1,孙堂友1,傅涛1,肖功利1,李琦1,刘兴鹏1,张秀云1,郭道友2,王相虎3,秦祖军1
《信息与电子工程前沿(英文)》 2021年 第22卷 第10期 页码 1370-1378 doi: 10.1631/FITEE.2000330
Changlin Cao, Jingxian Gu, Jingyao Zhang
《医学前沿(英文)》 2017年 第11卷 第2期 页码 169-177 doi: 10.1007/s11684-017-0505-z
关键词: soluble triggering receptor expressed on myeloid cells-1 infectious diseases diagnosis and prognosis biomarker
Molecular characterization of two suppressor of cytokine signaling 1 genes (
Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG
《农业科学与工程前沿(英文)》 2015年 第2卷 第1期 页码 73-83 doi: 10.15302/J-FASE-2015044
视觉知识引导的中国篆刻智能化生成 Research Article
张克俊1,2,张瑞1,殷叶航1,李一非3,伍文棋1,孙凌云1,2,吴飞1,邓晃煌1,潘云鹤1
《信息与电子工程前沿(英文)》 2022年 第23卷 第10期 页码 1479-1493 doi: 10.1631/FITEE.2100094
本文将传统篆刻艺术中的资源协同、设计创作、视觉呈现等过程以数字化方式再现,研制了篆刻艺术智能化创作的系统和平台(浙江大学智能篆刻系统:http://www. next.zju.edu.cn/seal/;篆刻搜索排版系统:http://www.next.zju.edu.cn/seal/search_app/),以视觉知识为引导突破计算机艺术学面临的难点问题。本文构建了包含字和印的求是篆刻数据库,并以此为视觉知识库,构建了篆字智能生成算法。此外,为创建印章布局,提出一种篆字变形算法调整印章字符,并结合视觉知识实现智能篆字布局,以实现智能结构。实验结果表明本文所提方法和系统可有效解决篆刻艺术生成中的难点问题,为篆刻艺术的守正与创新提供理论与应用借鉴。
光致旋转技术综述 Review Article
朱琦1,李楠1,苏鹤鸣1,李文强1,胡慧珠1,2
《信息与电子工程前沿(英文)》 2022年 第23卷 第2期 页码 171-185 doi: 10.1631/FITEE.2000338
关键词: 光镊;光致旋转;角动量;微纳转子
PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives
Yumeng Wang, Guiling Li
《医学前沿(英文)》 2019年 第13卷 第4期 页码 438-450 doi: 10.1007/s11684-018-0674-4
关键词: PD-1 PD-L1 immune checkpoint blockade antibody immunotherapy cervical cancer
标题 作者 时间 类型 操作
Expression of integrin in hepatic fibrosis and intervention of resveratrol
Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN
期刊论文
Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition
null
期刊论文
Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms
期刊论文
Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis
Changlin Cao, Jingxian Gu, Jingyao Zhang
期刊论文
Molecular characterization of two suppressor of cytokine signaling 1 genes (
Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG
期刊论文