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Chinmedomics facilitated quality-marker discovery of Sijunzi decoction to treat spleen qi deficiency

Qiqi Zhao, Xin Gao, Guangli Yan, Aihua Zhang, Hui Sun, Ying Han, Wenxiu Li, Liang Liu, Xijun Wang

《医学前沿（英文）》 2020年 第14卷 第3期   页码 335-356 doi: 10.1007/s11684-019-0705-9

摘要： Sijunzi decoction (SJZD) is a Chinese classical formula to treat spleen qi deficiency syndrome (SQDS) and has been widely used for thousands of years. However, the quality control (QC) standards of SJZD are insufficient. Chinmedomics has been designed to discover and verify bioactive compounds of a variety of formula rapidly. In this study, we used Chinmedomics to evaluate the SJZD’s efficacy against SQDS to discover the potential quality-markers (q-markers) for QC. A total of 56 compounds in SJZD were characterized , and 23 compounds were discovered . A total of 58 biomarkers were related to SQDS, and SJZD can adjust a large proportion of marker metabolites to normal level and then regulate the metabolic profile to the health status. A total of 10 constituents were absorbed as effective ingredients that were associated with overall efficacy. We preliminarily determined malonyl-ginsenoside Rb2 and ginsenoside Ro as the q-markers of ginseng; dehydrotumulosic acid and dihydroxy lanostene-triene-21-acid as the q-markers of poria; glycyrrhizic acid, isoglabrolide, and glycyrrhetnic acid as the q-markers of licorice; and 2-atractylenolide as the q-marker of macrocephala. According to the discovery of the SJZD q-markers, we can establish the quality standard that is related to efficacy.

关键词： traditional Chinese medicine     Sijunzi decoction     spleen qi deficiency syndrome     Chinmedomics     quality-marker    

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Overview of the quality standard research of traditional Chinese medicine

Huimin Gao, Zhimin Wang, Yujuan Li, Zhongzhi Qian

《医学前沿（英文）》 2011年 第5卷 第2期   页码 195-202 doi: 10.1007/s11684-011-0134-x

摘要： Traditional Chinese medicine (TCM) has been widely used for the prevention and treatment of various diseases for a long time in China. Due to its proven efficacy, wide applications, and low side effect, TCM has increasingly attracted worldwide attention. However, one of the biggest challenges facing the clinical practice of TCM is the uncontrollable quality. In this review, the progress of the development and the current status of quality standard as well as new quality control techniques introduced in (2010 edition), such as liquid chromatography hyphenated mass spectrometry (LC-MS), fingerprint, quantitative analysis of multi-components by single-marker (QAMS), thin layer chromatography bio-autographic assay (TLC-BAA), and DNA molecular marker technique, are briefly overviewed.

关键词： traditional Chinese medicine     quality standard     quality control     quantitative analysis of multi-components by single-marker    

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中药的质量标准——概念、进展与展望 Review

李亚卓, 谢莹, 赫宇霏, 侯文彬, 廖茂梁, 刘昌孝

《工程（英文）》 2019年 第5卷 第5期   页码 888-894 doi: 10.1016/j.eng.2019.01.015

摘要：

数千年来，中药作为一种重要的补充药物，被广泛应用于各种疾病的治疗中。然而，人们始终未能就其质量控制问题达成一致。中药不同于化学药品，后者往往具有明确且有效的质量标准。现行做法是评估众多草药和制剂中的一种（或几种）化合物的含量，以此用作质量标志物。但所评估的化合物可能既不与药物疗效密切相关，也不具有整体代表性。本文基于临床用途、复方配伍以及中药的生产工艺，对之前提出的中药质量标志物的新概念进行了进一步讨论。同时，还阐述了用于中药（包括草药、炮制品和制剂）定性和定量分析的实用技术方法，以促进发现和鉴定用作质量标志物的特定化学物质，由此形成新的质量控制模式。此外，本文还描述了目前中药质量控制领域所取得的进展。这些进展为中药质量控制的前景提供了有用信息。

关键词： 中药     质量标志物     质量控制    

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Transcriptome resources and genome-wide marker development for Japanese larch (

Wanfeng LI,Suying HAN,Liwang QI,Shougong ZHANG

《农业科学与工程前沿（英文）》 2014年 第1卷 第1期   页码 77-84 doi: 10.15302/J-FASE-2014010

摘要： While the differential responses of trees to changes in climatic and environmental conditions have been demonstrated as they age, the underlying mechanisms and age control of tree growth and development are complex and poorly understood particularly at a molecular level. In this paper, we present a transcriptome analysis of , a deciduous conifer that is widely-grown in the northern hemisphere and of significant ecological and economic value. Using high-throughput RNA sequencing, we obtained about 26 million reads from the stems of 1-, 2-, 5-, 10-, 25- and 50-year-old trees. Combining these with the published Roche 454 sequencing reads and the expressed sequence tags (both mainly from embryogenic cell cultures), we assembled 26670549 reads into 146786 transcripts, of which we annotated 79182 to support investigations of the molecular basis of tree aging and adaption, somatic embryogenesis and wood formation. Using these sequences we also identified many single-nucleotide polymorphisms, simple sequence repeats, and insertion and deletion markers to assist breeding and genetic diversity studies of .

关键词： Larix     transcriptome     age     wood formation     somatic embryogenesis     molecular marker    

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Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

null

《医学前沿（英文）》 2016年 第10卷 第1期   页码 52-60 doi: 10.1007/s11684-016-0433-3

摘要：

Hepatocellular carcinoma (HCC) is a lethal liver malignancy worldwide. In this study, we reported that protein phosphatase magnesium-dependent 1δ (PPM1D) was highly expressed in the majority of HCC cases (approximately 59%) and significantly associated with high serum α-fetoprotein (AFP) level (P= 0.044). Kaplan-Meier and Cox regression data indicated that PPM1D overexpression was an independent predictor of HCC-specific overall survival (HR, 2.799; 95% CI, 1.346–5.818, P = 0.006). Overexpressing PPM1D promoted cell viability and invasion, whereas RNA interference-mediated knockdown of PPM1D inhibited proliferation, invasion, and migration of cultured HCC cells. In addition, PPM1D suppression by small interfering RNA decreased the tumorigenicity of HCC cells in vivo. Overall, results suggest that PPM1D is a potential prognostic marker and therapeutic target for HCC.

关键词： PPM1D     hepatocellular carcinoma     prognosis     target therapy    

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Novel polymorphic EST-based microsatellite marker isolation and characterization from

Manosh Kumar BISWAS,Peng CHEN,Mohamed Hamdy AMAR,Xiuxin DENG

《农业科学与工程前沿（英文）》 2015年 第2卷 第1期   页码 60-65 doi: 10.15302/J-FASE-2015048

摘要： Novel simple sequence repeat (SSR) markers were developed to evaluate their utility for genetic diversity and breeding studies of and related species. A total of 108 primer pairs were characterized by PCR amplification experiments. Among these, 61 were polymorphic and transferable to other citrus species. The number of alleles per locus ranged from 2 to 6, with an average of 2.37 alleles per locus. The expected heterozygosity and observed heterozygosity ranged from 0 to 0.83 and 0 to 1.00, respectively. These novel polymorphic SSR markers will be useful for citrus cultivar identification and evaluation as well as breeding studies.

关键词： microsatellite     polymorphism     Poncirus trifoliata    

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Erratum to “Targeted Genotyping of a Whole-Gene Repertoire by an Ultrahigh-Multiplex and Flexible HD-Marker Erratum

Pingping Liu,Jia Lv,Cen Ma,Tianqi Zhang,Xiaowen Huang,Zhihui Yang,Lingling Zhang,Jingjie Hu,Shi Wang,Zhenmin Bao,

《工程（英文）》 2022年 第18卷 第11期   页码 259-259 doi: 10.1016/j.eng.2022.09.002

关键词： online     THE AUTHORS.Published     repertoire     behalf     Engineering     September     genotyping     Academy     HD-marker approach”     Education Press Limited Company.    

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China-CIMMYT collaboration enhances wheat improvement in China

Zhonghu HE, Xianchun XIA, Yong ZHANG, Yan ZHANG, Yonggui XIAO, Xinmin CHEN, Simin LI, Yuanfeng HAO, Awais RASHEED, Zhiyong XIN, Qiaosheng ZHUANG, Ennian YANG, Zheru FAN, Jun YAN, Ravi SINGH, Hans-Joachim BRAUN

《农业科学与工程前沿（英文）》 2019年 第6卷 第3期   页码 233-239 doi: 10.15302/J-FASE-2019254

摘要：

China and CIMMYT have collaborated on wheat improvement for over 40 years and significant progress has been achieved in five aspects in China. A standardized protocol for testing Chinese noodle quality has been established with three selection criteria, i.e., gluten quality, starch viscosity and flour color are identified as being responsible for noodle quality. Genomic approaches have been used to develop and validate gene-specific markers, leading to the establishment of a KASP platform, and seven cultivars have been released through application of molecular marker technology. Methodology for breeding adult-plant resistance to yellow rust, leaf rust and powdery mildew, based on the pleiotropic effect of minor genes has been established, resulting in release of six cultivars. More than 330 cultivars derived from CIMMYT germplasm have been released and are now grown over 9% of the Chinese wheat production area. Additionally, physiological approaches have been used to characterize yield potential and develop high-efficiency phenotyping platforms. CIMMYT has also provided valuable training for Chinese scientists. Development of climate-resilient cultivars with application of new technology will be the priority for future collaboration.

关键词： adult-plant resistance     bread wheat     breeding     gene-specific marker     germplasm exchange     processing quality    

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From total quality management to Quality 4.0: A systematic literature review and future research agenda

《工程管理前沿（英文）》 2023年 第10卷 第2期   页码 191-205 doi: 10.1007/s42524-022-0243-z

摘要： Quality 4.0 is an emerging concept that has been increasingly appreciated because of the intensification of competition, continually changing customer requirements and technological evolution. It deals with aligning quality management practices with the emergent capabilities of Industry 4.0 to improve cost, time, and efficiency and increase product quality. This article aims to comprehensively review extant studies related to Quality 4.0 to uncover current research trends, distil key research topics, and identify areas for future research. Thus, 46 journal articles extracted from the Scopus database from 2017 to 2022 were collected and reviewed. A descriptive analysis was first performed according to the year-wise publication, sources of publication, and research methods. Then, the selected articles were analyzed and classified according to four research themes: Quality 4.0 concept, Quality 4.0 implementation, quality management in Quality 4.0, and Quality 4.0 model and application. By extracting the literature review findings, we identify the Quality 4.0 definitions and features, develop the quality curve theory, and highlight future research opportunities. This study supports practitioners, managers, and academicians in effectively recognizing and applying Quality 4.0 to enhance customer satisfaction, achieve innovation enterprise efficiency, and increase organizational competitiveness in the era of Industry 4.0.

关键词： quality management     Quality 4.0     Industry 4.0     literature review     predictive quality    

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as proxies for yield potential and heat stress tolerance in spring wheat: heritability estimates and marker-trait

Caiyun LIU, Francisco PINTO, C. Mariano COSSANI, Sivakumar SUKUMARAN, Matthew P. REYNOLDS

《农业科学与工程前沿（英文）》 2019年 第6卷 第3期   页码 296-308 doi: 10.15302/J-FASE-2019269

摘要：

The application of spectral reflectance indices (SRIs) as proxies to screen for yield potential (YP) and heat stress (HS) is emerging in crop breeding programs. Thus, a comparison of SRIs and their associations with grain yield (GY) under YP and HS conditions is important. In this study, we assessed the usefulness of 27 SRIs for indirect selection for agronomic traits by evaluating an elite spring wheat association mapping initiative (WAMI) population comprising 287 elite lines under YP and HS conditions. Genetic and phenotypic analysis identified 11 and 9 SRIs in different developmental stages as efficient indirect selection indices for yield in YP and HS conditions, respectively. We identified enhanced vegetation index (EVI) as the common SRI associated with GY under YP at booting, heading and late heading stages, whereas photochemical reflectance index (PRI) and normalized difference vegetation index (NDVI) were the common SRIs under booting and heading stages in HS. Genome-wide association study (GWAS) using 18704 single nucleotide polymorphisms (SNPs) from Illumina iSelect 90K identified 280 and 43 marker-trait associations for efficient SRIs at different developmental stages under YP and HS, respectively. Common genomic regions for multiple SRIs were identified in 14 regions in 9 chromosomes: 1B (60–62 cM), 3A (15, 85–90, 101–105 cM), 3B (132–134 cM), 4A (47–51 cM), 4B (71–75 cM), 5A (43–49, 56–60, 89–93 cM), 5B (124–125 cM), 6A (80–85 cM), and 6B (57–59, 71 cM). Among them, SNPs in chromosome 5A (89–93 cM) and 6A (80–85 cM) were co-located for yield and yield related traits. Overall, this study highlights the utility of SRIs as proxies for GY under YP and HS. High heritability estimates and identification of marker-trait associations indicate that SRIs are useful tools for understanding the genetic basis of agronomic and physiological traits.

关键词： genome-wide association study (GWAS)     heat tolerance     spectral reflectance     spring wheat    

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UNREDUCED MEGAGAMETOPHYTE FORMATION VIA SECOND DIVISION RESTITUTION CONTRIBUTES TO TETRAPLOID PRODUCTION IN INTERPLOIDY CROSSES WITH ‘ORAH’ MANDARIN (CITRUS RETICULATA)

《农业科学与工程前沿（英文）》 2021年 第8卷 第2期

摘要：

Seedless fruits are desirable in the citrus fresh fruit market. Triploid production via diploid × tetraploid interploidy crosses is thought to be the most efficient and widely-used strategy for the breeding of seedless citrus. Although ‘Orah’ mandarin has desirable organoleptic qualities, seeds in the fruits weaken its market competitiveness. To produce new seedless cultivars that are similar to ‘Orah’ mandarin, we performed three 2x × 4x crosses using ‘Orah’ mandarin as the seed parent to regenerate triploid plantlets. A total of 182 triploid and 36 tetraploid plantlets were obtained. By analyzing their genetic origins using nine novel single nucleotide polymorphism (SNP) markers, all of the triploids and tetraploids derived from these three crosses were proven to be hybrids. Also, we demonstrated that 2n megagametophyte formation in ‘Orah’ mandarin result in tetraploid production in these three interploidy crosses. These tetraploid plantlets were genotyped using eight pericentromeric SNP markers and nine centromere distal SNP markers. Based on the genotypes of the 2n megagametophytes, the parental heterozygosity rates in 16 SNP loci and all 2n megagametophytes were less than 50%, indicating that second division restitution was the mechanism underlying 2n megagametophyte formation at both the population and individual levels. These triploid hybrids enrich the germplasm available for seedless breeding. Moreover, the tetraploid hybrids are valuable as parents for ploidy breeding for the production of seedless citrus fruits.

 

关键词： Citrus / 2n gamete / interploidy hybridization / pericentromeric SNP marker / second division restitution    

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Research and establishment of enterprise quality metadata standard

SONG Han, LI Jie, ZHANG Genbao

《机械工程前沿（英文）》 2008年 第3卷 第1期   页码 106-110 doi: 10.1007/s11465-008-0019-0

摘要： Enabling quality managers to utilize and manage quality data efficiently under modern quality management circumstances is a primary issue for improving enterprise quality management. A concept of quality metadata is proposed in this paper, which can help quality managers gain a deeper understanding of various features of quality data and establish a more stable foundation for further use and management of such data. The procedure of establishing quality metadata standards is emphasized in the paper, and the content structure and description scheme are given. Finally, a summary is made and future work is prospected.

关键词： enterprise quality     foundation     description     quality management     primary    

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Foxtail millet: nutritional and eating quality, and prospects for genetic improvement

Lu HE,Bin ZHANG,Xingchun WANG,Hongying LI,Yuanhuai HAN

《农业科学与工程前沿（英文）》 2015年 第2卷 第2期   页码 124-133 doi: 10.15302/J-FASE-2015054

摘要： Foxtail millet is a minor yet important crop in some areas of the world, particularly northern China. It has strong adaptability to abiotic stresses, especially drought, and poor soil. It also has high nutritional value. Foxtail millet is rich in essential amino acids, fatty acids and minerals, and is considered to be one of the most digestible and non-allergenic grains available and has significant importance for human health. Given foxtail millet’s ability to adapt to abiotic stresses associated with climate change, it is more important than ever to develop breeding strategies that facilitate the increasing demand for high quality grain that better satisfies consumers. Here we review research on foxtail millet quality evaluation, appearance, cooking and eating quality at the phenotypic level. We review analysis of the main nutrients in foxtail millet, their relationships and the biochemical and genetic factors affecting their accumulation. In addition, we review past progress in breeding this regionally important crop, outline current status of breeding of foxtail millet, and make suggestions to improve grain quality.

关键词： foxtail millet     grain quality     quality evaluation     breeding for quality    

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A review of hydrological/water-quality models

Liangliang GAO,Daoliang LI

《农业科学与工程前沿（英文）》 2014年 第1卷 第4期   页码 267-276 doi: 10.15302/J-FASE-2014041

摘要： Water quality models are important in predicting the changes in surface water quality for environmental management. A range of water quality models are wildly used, but every model has its advantages and limitations for specific situations. The aim of this review is to provide a guide to researcher for selecting a suitable water quality model. Eight well known water quality models were selected for this review: SWAT, WASP, QUALs, MIKE 11, HSPF, CE-QUAL-W2, ELCOM-CAEDYM and EFDC. Each model is described according to its intended use, development, simulation elements, basic principles and applicability (e.g., for rivers, lakes, and reservoirs and estuaries). Currently, the most important trends for future model development are: (1) combination models—individual models cannot completely solve the complex situations so combined models are needed to obtain the most appropriate results, (2) application of artificial intelligence and mechanistic models combined with non-mechanistic models will provide more accurate results because of the realistic parameters derived from non-mechanistic models, and (3) integration with remote sensing, geographical information and global position systems (3S) —3S can solve problems requiring large amounts of data.

关键词： water quality models     applications     future trends    

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Evaluation of ICUs and weight of quality control indicators: an exploratory study based on Chinese ICUquality data from 2015 to 2020

《医学前沿（英文）》 2023年 第17卷 第4期   页码 675-684 doi: 10.1007/s11684-022-0970-x

摘要： This study aimed to explore key quality control factors that affected the prognosis of intensive care unit (ICU) patients in Chinese mainland over six years (2015−2020). The data for this study were from 31 provincial and municipal hospitals (3425 hospital ICUs) and included 2 110 685 ICU patients, for a total of 27 607 376 ICU hospitalization days. We found that 15 initially established quality control indicators were good predictors of patient prognosis, including percentage of ICU patients out of all inpatients (%), percentage of ICU bed occupancy of total inpatient bed occupancy (%), percentage of all ICU inpatients with an APACHE II score ≥15 (%), three-hour (surviving sepsis campaign) SSC bundle compliance (%), six-hour SSC bundle compliance (%), rate of microbe detection before antibiotics (%), percentage of drug deep venous thrombosis (DVT) prophylaxis (%), percentage of unplanned endotracheal extubations (%), percentage of patients reintubated within 48 hours (%), unplanned transfers to the ICU (%), 48-h ICU readmission rate (%), ventilator associated pneumonia (VAP) (per 1000 ventilator days), catheter related blood stream infection (CRBSI) (per 1000 catheter days), catheter-associated urinary tract infections (CAUTI) (per 1000 catheter days), in-hospital mortality (%). When exploratory factor analysis was applied, the 15 indicators were divided into 6 core elements that varied in weight regarding quality evaluation: nosocomial infection management (21.35%), compliance with the Surviving Sepsis Campaign guidelines (17.97%), ICU resources (17.46%), airway management (15.53%), prevention of deep-vein thrombosis (14.07%), and severity of patient condition (13.61%). Based on the different weights of the core elements associated with the 15 indicators, we developed an integrated quality scoring system defined as F score=21.35%×nosocomial infection management + 17.97%×compliance with SSC guidelines + 17.46%×ICU resources + 15.53%×airway management + 14.07%×DVT prevention + 13.61%×severity of patient condition. This evidence-based quality scoring system will help in assessing the key elements of quality management and establish a foundation for further optimization of the quality control indicator system.

关键词： critical care medicine     quality control     evaluation     exploratory factor analysis (EFA) model    

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标题 作者 时间 类型 操作

Chinmedomics facilitated quality-marker discovery of Sijunzi decoction to treat spleen qi deficiency

Qiqi Zhao, Xin Gao, Guangli Yan, Aihua Zhang, Hui Sun, Ying Han, Wenxiu Li, Liang Liu, Xijun Wang

期刊论文

Overview of the quality standard research of traditional Chinese medicine

Huimin Gao, Zhimin Wang, Yujuan Li, Zhongzhi Qian

期刊论文

中药的质量标准——概念、进展与展望

李亚卓, 谢莹, 赫宇霏, 侯文彬, 廖茂梁, 刘昌孝

期刊论文

Transcriptome resources and genome-wide marker development for Japanese larch (

Wanfeng LI,Suying HAN,Liwang QI,Shougong ZHANG

期刊论文

Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

null

期刊论文

Novel polymorphic EST-based microsatellite marker isolation and characterization from

Manosh Kumar BISWAS,Peng CHEN,Mohamed Hamdy AMAR,Xiuxin DENG

期刊论文

Erratum to “Targeted Genotyping of a Whole-Gene Repertoire by an Ultrahigh-Multiplex and Flexible HD-Marker

Pingping Liu,Jia Lv,Cen Ma,Tianqi Zhang,Xiaowen Huang,Zhihui Yang,Lingling Zhang,Jingjie Hu,Shi Wang,Zhenmin Bao,

期刊论文

China-CIMMYT collaboration enhances wheat improvement in China

Zhonghu HE, Xianchun XIA, Yong ZHANG, Yan ZHANG, Yonggui XIAO, Xinmin CHEN, Simin LI, Yuanfeng HAO, Awais RASHEED, Zhiyong XIN, Qiaosheng ZHUANG, Ennian YANG, Zheru FAN, Jun YAN, Ravi SINGH, Hans-Joachim BRAUN

期刊论文

From total quality management to Quality 4.0: A systematic literature review and future research agenda

期刊论文

as proxies for yield potential and heat stress tolerance in spring wheat: heritability estimates and marker-trait

Caiyun LIU, Francisco PINTO, C. Mariano COSSANI, Sivakumar SUKUMARAN, Matthew P. REYNOLDS

期刊论文

UNREDUCED MEGAGAMETOPHYTE FORMATION VIA SECOND DIVISION RESTITUTION CONTRIBUTES TO TETRAPLOID PRODUCTION IN INTERPLOIDY CROSSES WITH ‘ORAH’ MANDARIN (CITRUS RETICULATA)

期刊论文

Research and establishment of enterprise quality metadata standard

SONG Han, LI Jie, ZHANG Genbao

期刊论文

Foxtail millet: nutritional and eating quality, and prospects for genetic improvement

Lu HE,Bin ZHANG,Xingchun WANG,Hongying LI,Yuanhuai HAN

期刊论文

A review of hydrological/water-quality models

Liangliang GAO,Daoliang LI

期刊论文

Evaluation of ICUs and weight of quality control indicators: an exploratory study based on Chinese ICUquality data from 2015 to 2020

期刊论文