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Interplay between diet and genetic susceptibility in obesity and related traits
Tiange Wang, Min Xu, Yufang Bi, Guang Ning
《医学前沿(英文)》 2018年 第12卷 第6期 页码 601-607 doi: 10.1007/s11684-018-0648-6
The incidence of obesity has been rapidly increasing, and this condition has become a major public health threat. A substantial shift in environmental factors and lifestyle, such as unhealthy diet, is among the major driving forces of the global obesity pandemic. Longitudinal studies and randomized intervention trials have shown that genetic susceptibility to obesity may interact with dietary factors in relation to the body mass index and risk of obesity. This review summarized data from recent longitudinal studies and intervention studies on variations and diets and discussed the challenges and future prospects related to this area and public health implications.
DQB1*060101 may contribute to susceptibility to immunoglobulin A nephropathy in southern Han Chinese
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《医学前沿(英文)》 2016年 第10卷 第4期 页码 507-516 doi: 10.1007/s11684-016-0475-6
Immunoglobulin A nephropathy (IgAN) is a common form of chronic glomerulonephritis with unknown pathogenesis. Accumulating evidences have shown the ethnic-specific association between certain human leukocyte antigen (HLA) alleles and IgAN susceptibility. This study was designed to explore the relationship between HLA-DQB1 alleles and disease susceptibility and clinical manifestations of patients with IgAN in southern Han Chinese. A PCR sequence-based typing technique was used to detect HLA-DQB1 alleles in 217 IgAN patients and 229 healthy subjects. Clinical data were collected from each patient at the time of renal biopsy. Twenty HLA-DQB1 alleles were detected in IgAN patients and healthy subjects. High frequency of HLA-DQB1*060101 and low frequency of HLA-DQB1*030101 were observed in IgAN patients compared with healthy controls. Further stratification analysis revealed that the frequency of DQB1*060101 was significantly higher in patients with urine protein≥1.0 g/24 h than in patients with urine protein<1.0 g/24 h. In combination with our previous DRB1 results, we also analyzed the association of DRB1-DQB1 haplotypes with IgAN. We found that the frequency of haplotype DRB1*090102-DQB1*060101 was significantly higher [odds ratio (OR) = 4.409, Pc = 0.016], whereas that of HLA-DRB1*070101-DQB1*020101 was significantly lower (OR= 0.194, Pc = 0.016) compared with healthy controls. Our study indicated that HLA-DQB1*060101 alleles may be a potential predictor of high-risk IgAN susceptibility in Chinese Han population.
关键词: DQB1 human leukocyte antigen (HLA) IgA nephropathy haplotype association study
Genetic Study Identifies CBLN4 as a Novel Susceptibility Gene for Accident Proneness
Shu-lin Zhang,Hui-qing Jin,Yang Song,Wan-sheng Yu,Liang-dan Sun
《工程管理前沿(英文)》 2016年 第3卷 第1期 页码 30-38 doi: 10.15302/J-FEM-2016008
关键词: accident proneness genome-wide association study (GWAS) dopamine (DA) ACTH susceptibility gene traffic accident epidemiology accident prevention traffic safety three-dimensional model
null
《医学前沿(英文)》 2015年 第9卷 第2期 页码 146-161 doi: 10.1007/s11684-014-0373-8
Obesity prevalence has increased in recent years. Lifestyle change fuels obesity, but genetic factors cause more than 50% of average variations in obesity. The advent of genome-wide association studies (GWAS) has hastened the progress of polygenic obesity research. As of this writing, more than 73 obesity susceptibility loci have been identified in ethnic groups through GWAS. The identified loci explain only 2% to 4% of obesity heritability, thereby indicating that a large proportion of loci remain undiscovered. Thus, the next step is to identify and confirm novel loci, which may exhibit smaller effects and lower allele frequencies than established loci. However, achieving these tasks has been difficult for researchers. GWAS help researchers discover the causal loci. Moreover, numerous biological studies have been performed on the polygenic effects on obesity, such as studies on fat mass- and obesity-associated gene (FTO), but the role of these polygenic effects in the mechanism of obesity remains unclear. Thus, obesity-causing variations should be identified, and insights into the biology of polygenic effects on obesity are needed.
关键词: obesity genetics genome-wide association studies body mass index fat mass- and obesity-associated gene
Is tailored therapy based on antibiotic susceptibility effective?
Jie Pan, Zhengchao Shi, Dingsai Lin, Ningmin Yang, Fei Meng, Lang Lin, Zhencheng Jin, Qingjie Zhou, Jiansheng Wu, Jianzhong Zhang, Youming Li
《医学前沿(英文)》 2020年 第14卷 第1期 页码 43-50 doi: 10.1007/s11684-019-0706-8
关键词: tailored triple therapy tailored bismuth-containing quadruple therapy traditional bismuth-containing quadruple therapy antibiotic susceptibility testing eradication rates
Susceptibility of male and female Japanese medaka (
Nannan LIU, Mei MA, Yiping XU, Jinmiao ZHA, Kaifeng RAO, Zijian WANG
《环境科学与工程前沿(英文)》 2013年 第7卷 第1期 页码 77-84 doi: 10.1007/s11783-012-0466-z
关键词: 2 4 6-trichlorophenol genotoxicity Japanese medaka piscine micronucleus test in peripheral erythrocytes gender difference
Functional XPF polymorphisms associated with lung cancer susceptibility in a Chinese population
Dian-Ke YU PhD, Chen WU MD, Wen TAN MD, Dong-Xin LIN MD,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 82-89 doi: 10.1007/s11684-010-0014-9
关键词: XPF polymorphism lung cancer
SUN Pin, ZHANG Zhongbin, WU Fen, WAN Junxiang, JIN Xibeng, XIA Zhaolin
《医学前沿(英文)》 2007年 第1卷 第3期 页码 320-326 doi: 10.1007/s11684-007-0062-y
关键词: case-control rs2854451 regression analysis haplotype further research
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《医学前沿(英文)》 2016年 第10卷 第4期 页码 517-521 doi: 10.1007/s11684-016-0480-9
This study aimed to compare the antimicrobial activities of topical agents against Propionibacterium acnes isolated from patients admitted to a hospital in Shanghai, China. The minimal inhibitory concentrations of the cultured P. acnes were determined in accordance with the Clinical and Laboratory Standards Institute. Susceptibilities to clindamycin and erythromycin were compared in terms of gender, age, disease duration, previous treatment, and disease severity. A total of 69 P. acnes strains were isolated from 98 patients (70.41%). The susceptibility to triple antibiotic ointment (neomycin/bacitracin/polymyxin B) and bacitracin was 100%. The susceptibility to fusidic acid was 92.7%. The resistance rates to neomycin sulfate, erythromycin, and clindamycin were 11.7%, 49.3%, and 33.4%, respectively. The high resistance rate to clindamycin and erythromycin was significantly affected by gender, previous treatment, and disease severity rather than by age and disease duration. Topical antibiotics should not be used separately for long-term therapy to avoid multiresistance. The use of topical antibiotics should be determined by clinicians on the basis of clinical conditions.
关键词: antimicrobial susceptibility/resistance Propionibacterium acnes topical antibiotics in vitro study
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《医学前沿(英文)》 2015年 第9卷 第4期 页码 478-486 doi: 10.1007/s11684-015-0420-0
Telomeres play a critical role in biological ageing by maintaining chromosomal integrity and preventing chromosome ends fusion. Epidemiological studies have suggested that inter-individual differences of telomere length could affect predisposition to multiple cancers, but evidence regarding esophageal squamous cell carcinoma (ESCC) was still uncertain. Several telomere length-related single nucleotide polymorphisms (TL-SNPs) in Caucasians have been reported in genome-wide association studies. However, the effects of telomere length and TL-SNPs on ESCC development are unclear. Therefore, we conducted a case-control study (1045 ESCC cases and 1433 controls) to evaluate the associations between telomere length, TL-SNPs, and ESCC risk in Chinese population. As a result, ESCC cases showed overall shorter relative telomere length (RTL) (median: 1.34) than controls (median: 1.50, P<0.001). More interestingly, an evident nonlinear U-shaped association was observed between RTL and ESCC risk (P<0.001), with odds ratios (95% confidence interval) equal to 2.40 (1.84–3.14), 1.36 (1.03–1.79), 1.01 (0.76–1.35), and 1.37 (1.03–1.82) for individuals in the 1st (the shortest), 2nd, 3rd, and 5th (the longest) quintile, respectively, compared with those in the 4th quintile as reference group. No significant associations were observed between the eight reported TL-SNPs and ESCC susceptibility. These findings suggest that either short or extremely long telomeres may be risk factors for ESCC in the Chinese population.
关键词: esophageal squamous cell carcinoma telomere length genetic variants susceptibility genome-wide association study
Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 90-95 doi: 10.1007/s11684-010-0021-x
关键词: cyclooxygenase-2 gene single nucleotide polymorphisms susceptibility primary hepatocellular carcinoma hepatitis B virus infection
2014—2016年食品动物源RE-cmeABC阳性弯曲菌流行与耐药性现状 Article
刘德俊, 刘蔚雯, 李星, 姚红, 沈张奇, 汪洋, 沈建忠
《工程(英文)》 2020年 第6卷 第1期 页码 34-39 doi: 10.1016/j.eng.2019.10.013
弯曲菌是引起人类胃肠炎的一类重要食源性致病菌。RE-CmeABC是近年来弯曲菌中新发现的一种增强型耐药外排泵,可介导对兽医和人医临床治疗弯曲菌感染的重要药物,如氟喹诺酮类、酰胺醇类、大环内酯类及四环素类等药物的高水平耐药,而目前尚未有对该外排泵的大范围流行病学调查。因此,本研究调查了2014—2016年连续三年间我国山东、上海和广东等三个重点养殖区食品动物源RE-cmeABC阳性弯曲菌的流行与耐药性现状。结果显示,在1088株弯曲菌(931株结肠弯曲菌与157株空肠弯曲菌)中共检测出122株(11.2%)RE-cmeABC阳性菌株,包括111株(70.7%)空肠弯曲菌与11株(1.2%)结肠弯曲菌,空肠弯曲菌中RE-cmeABC的阳性率显著高于结肠弯曲菌。111株RE-cmeABC阳性空肠弯曲菌与46株RE-cmeABC阴性空肠弯曲菌相比在氟苯尼考、克林霉素和红霉素的耐药率上具有显著差异(P < 0.05),而在环丙沙星、四环素和庆大霉素的耐药率上无显著差异。然而,携带RE-cmeABC的菌株可以使环丙沙星与四环素对弯曲菌的MIC值分布趋于更高水平范围。脉冲场凝胶电泳分型(PFGE)结果显示RE-cmeABC阳性菌株在上海和广东地区以水平传播为主,在山东地区以克隆传播为主;三株分离于上海和广东的阳性菌为同一克隆型,4株分离于上海和山东的阳性菌为同一克隆型。本研究表明RE-cmeABC已在我国食品动物源弯曲菌中广泛流行,对公共卫生安全具有潜在威胁。
关键词: RE- cmeABC 弯曲菌 环丙沙星 氟苯尼考
Na Qin, Yuancheng Li, Cheng Wang, Meng Zhu, Juncheng Dai, Tongtong Hong, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Gary Goodman, Stig E. Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeboller, Gadi Rennert, Susanne Arnold, Paul Brennan, John K. Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J. Hung, Angeline Andrew, Lambertus A. Kiemeney, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Penella Woll, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Victoria L. Stevens, Guangfu Jin, David C. Christiani, Zhibin Hu, Christopher I. Amos, Hongxia Ma, Hongbing Shen
《医学前沿(英文)》 2021年 第15卷 第2期 页码 275-291 doi: 10.1007/s11684-020-0779-4
关键词: lung cancer genome-wide association study function annotation immune homologous recombination repair deficiency genetic heterogeneity
标题 作者 时间 类型 操作
Interplay between diet and genetic susceptibility in obesity and related traits
Tiange Wang, Min Xu, Yufang Bi, Guang Ning
期刊论文
DQB1*060101 may contribute to susceptibility to immunoglobulin A nephropathy in southern Han Chinese
null
期刊论文
Genetic Study Identifies CBLN4 as a Novel Susceptibility Gene for Accident Proneness
Shu-lin Zhang,Hui-qing Jin,Yang Song,Wan-sheng Yu,Liang-dan Sun
期刊论文
Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies
null
期刊论文
Is tailored therapy based on antibiotic susceptibility effective?
Jie Pan, Zhengchao Shi, Dingsai Lin, Ningmin Yang, Fei Meng, Lang Lin, Zhencheng Jin, Qingjie Zhou, Jiansheng Wu, Jianzhong Zhang, Youming Li
期刊论文
Susceptibility of male and female Japanese medaka (
Nannan LIU, Mei MA, Yiping XU, Jinmiao ZHA, Kaifeng RAO, Zijian WANG
期刊论文
Functional XPF polymorphisms associated with lung cancer susceptibility in a Chinese population
Dian-Ke YU PhD, Chen WU MD, Wen TAN MD, Dong-Xin LIN MD,
期刊论文
Association of the genetic polymorphism of EPHX1 and EPHX2 with the susceptibility to chronic benzene
SUN Pin, ZHANG Zhongbin, WU Fen, WAN Junxiang, JIN Xibeng, XIA Zhaolin
期刊论文
Antimicrobial activity of topical agents against Propionibacterium acnes: an in vitro study of clinical isolates from a hospital in Shanghai, China
null
期刊论文
U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control study in Chinese population
null
期刊论文
Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-control study in Han Chinese people
Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,
期刊论文
Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between
Na Qin, Yuancheng Li, Cheng Wang, Meng Zhu, Juncheng Dai, Tongtong Hong, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Gary Goodman, Stig E. Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeboller, Gadi Rennert, Susanne Arnold, Paul Brennan, John K. Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J. Hung, Angeline Andrew, Lambertus A. Kiemeney, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Penella Woll, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Victoria L. Stevens, Guangfu Jin, David C. Christiani, Zhibin Hu, Christopher I. Amos, Hongxia Ma, Hongbing Shen
期刊论文