检索范围:
排序: 展示方式:
A genome-wide association study of five meat quality traits in Yorkshire pigs
Qian DONG,Huiying LIU,Xinyun LI,Wei WEI,Shuhong ZHAO,Jianhua CAO
《农业科学与工程前沿(英文)》 2014年 第1卷 第2期 页码 137-143 doi: 10.15302/J-FASE-2014014
关键词: Pig GWAS meat quality trait SNP
Genome-wide association studies: inherent limitations and future challenges
null
《医学前沿(英文)》 2012年 第6卷 第4期 页码 444-450 doi: 10.1007/s11684-012-0225-3
Genome-wide association studies (GWAS) have achieved great success in identifying genetic variants related to complex human diseases such as cancer and have provided valuable insights into their genetic architecture. Recently, GWAS is quite the fashion in China. However, there are issues related to its nature. Enormous work needs to be done in the post-GWAS era. Deep sequencing followed by functional studies will be needed to elucidate the underpinning biological mechanisms and further translate GWAS findings into medical practice. Along with pharmacogenomics, the success of GWAS in identifying genetic risk factors and genetic differences in drug response has been gradually enabling personalized medicine. In this article, we used hepatocellular carcinoma (HCC) as an example to demonstrate some of the inherent limitations and summarized future challenges of GWAS.
关键词: genome-wide association studies (GWAS) genetic variant cancer limitation challenge
null
《医学前沿(英文)》 2015年 第9卷 第2期 页码 146-161 doi: 10.1007/s11684-014-0373-8
Obesity prevalence has increased in recent years. Lifestyle change fuels obesity, but genetic factors cause more than 50% of average variations in obesity. The advent of genome-wide association studies (GWAS) has hastened the progress of polygenic obesity research. As of this writing, more than 73 obesity susceptibility loci have been identified in ethnic groups through GWAS. The identified loci explain only 2% to 4% of obesity heritability, thereby indicating that a large proportion of loci remain undiscovered. Thus, the next step is to identify and confirm novel loci, which may exhibit smaller effects and lower allele frequencies than established loci. However, achieving these tasks has been difficult for researchers. GWAS help researchers discover the causal loci. Moreover, numerous biological studies have been performed on the polygenic effects on obesity, such as studies on fat mass- and obesity-associated gene (FTO), but the role of these polygenic effects in the mechanism of obesity remains unclear. Thus, obesity-causing variations should be identified, and insights into the biology of polygenic effects on obesity are needed.
关键词: obesity genetics genome-wide association studies body mass index fat mass- and obesity-associated gene
Genome-wide association study of the backfat thickness trait in two pig populations
Dandan ZHU,Xiaolei LIU,Rothschild MAX,Zhiwu ZHANG,Shuhong ZHAO,Bin FAN
《农业科学与工程前沿(英文)》 2014年 第1卷 第2期 页码 91-95 doi: 10.15302/J-FASE-2014005
关键词: backfat thickness SNP chip genome-wide association study compressed mixed linear model pig
Xingwang WANG, Rongrong DING, Jianping QUAN, Linxue YANG, Ming YANG, Enqin ZHENG, Dewu LIU, Gengyuan CAI, Zhenfang WU, Jie YANG
《农业科学与工程前沿(英文)》 2017年 第4卷 第3期 页码 335-341 doi: 10.15302/J-FASE-2017152
关键词: Duroc pigs genome-wide association analysis intramuscular fat
Genetic Study Identifies CBLN4 as a Novel Susceptibility Gene for Accident Proneness
Shu-lin Zhang,Hui-qing Jin,Yang Song,Wan-sheng Yu,Liang-dan Sun
《工程管理前沿(英文)》 2016年 第3卷 第1期 页码 30-38 doi: 10.15302/J-FEM-2016008
关键词: accident proneness genome-wide association study (GWAS) dopamine (DA) ACTH susceptibility gene traffic accident epidemiology accident prevention traffic safety three-dimensional model
null
《医学前沿(英文)》 2015年 第9卷 第4期 页码 478-486 doi: 10.1007/s11684-015-0420-0
Telomeres play a critical role in biological ageing by maintaining chromosomal integrity and preventing chromosome ends fusion. Epidemiological studies have suggested that inter-individual differences of telomere length could affect predisposition to multiple cancers, but evidence regarding esophageal squamous cell carcinoma (ESCC) was still uncertain. Several telomere length-related single nucleotide polymorphisms (TL-SNPs) in Caucasians have been reported in genome-wide association studies. However, the effects of telomere length and TL-SNPs on ESCC development are unclear. Therefore, we conducted a case-control study (1045 ESCC cases and 1433 controls) to evaluate the associations between telomere length, TL-SNPs, and ESCC risk in Chinese population. As a result, ESCC cases showed overall shorter relative telomere length (RTL) (median: 1.34) than controls (median: 1.50, P<0.001). More interestingly, an evident nonlinear U-shaped association was observed between RTL and ESCC risk (P<0.001), with odds ratios (95% confidence interval) equal to 2.40 (1.84–3.14), 1.36 (1.03–1.79), 1.01 (0.76–1.35), and 1.37 (1.03–1.82) for individuals in the 1st (the shortest), 2nd, 3rd, and 5th (the longest) quintile, respectively, compared with those in the 4th quintile as reference group. No significant associations were observed between the eight reported TL-SNPs and ESCC susceptibility. These findings suggest that either short or extremely long telomeres may be risk factors for ESCC in the Chinese population.
关键词: esophageal squamous cell carcinoma telomere length genetic variants susceptibility genome-wide association study
Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction
Hong LI,Ziding ZHANG
《农业科学与工程前沿(英文)》 2016年 第3卷 第2期 页码 102-112 doi: 10.15302/J-FASE-2016100
关键词: plant–pathogen interactions systems biology omics plant immunity protein–protein interaction network
Transcriptome resources and genome-wide marker development for Japanese larch (
Wanfeng LI,Suying HAN,Liwang QI,Shougong ZHANG
《农业科学与工程前沿(英文)》 2014年 第1卷 第1期 页码 77-84 doi: 10.15302/J-FASE-2014010
关键词: Larix transcriptome age wood formation somatic embryogenesis molecular marker
Development of Machine Learning Methods for Accurate Prediction of Plant Disease Resistance
Qi Liu,Shi-min Zuo,Shasha Peng,Hao Zhang,Ye Peng,Wei Li,Yehui Xiong,Runmao Lin,Zhiming Feng,Huihui Li,Jun Yang,Guo-Liang Wang,Houxiang Kang,
《工程(英文)》 doi: 10.1016/j.eng.2024.03.014
关键词: Predicting plant disease resistance (PPDR) Genomic selection (GS) Machine learning (ML) Genome-wide association study (GWAS)
Genome-wide search for candidate genes determining vertebrae number in pigs
Longchao ZHANG, Jingwei YUE, Xin LIU, Jing LIANG, Kebin ZHAO, Hua YAN, Na LI, Lei PU, Yuebo ZHANG, Huibi SHI, Ligang WANG, Lixian WANG
《农业科学与工程前沿(英文)》 2017年 第4卷 第3期 页码 327-334 doi: 10.15302/J-FASE-2017163
关键词: genome-wide association study number of vertebrae pig SSC7 TGFβ3
Hongxia MIAO,Peiguang SUN,Yulu MIAO,Juhua LIU,Jianbin ZHANG,Caihong JIA,Jingyi WANG,Zhuo WANG,Zhiqiang JIN,Biyu XU
《农业科学与工程前沿(英文)》 2016年 第3卷 第4期 页码 346-356 doi: 10.15302/J-FASE-2016127
关键词: β-amylase banana genome-wide identification fruit development abiotic stress
A post-GWAS replication study confirming the association of
Shaohua YANG,Chao QI,Yan XIE,Xiaogang CUI,Yahui GAO,Jianping JIANG,Li JIANG,Shengli ZHANG,Qin ZHANG,Dongxiao SUN
《农业科学与工程前沿(英文)》 2014年 第1卷 第4期 页码 321-330 doi: 10.15302/J-FASE-2014037
关键词: GWAS functional annotation Chinese Holstein milk production traits C14H8orf33 gene single nucleotide polymorphisms association study
QIN Lunxiu, TANG Zhaoyou, GUAN Xinyuan, YE Qinghai, JIA Huliang, REN Ning
《医学前沿(英文)》 2008年 第2卷 第3期 页码 211-215 doi: 10.1007/s11684-008-0041-y
关键词: sensitive genome-wide prediction genome-wide microsatellite frequency Hepatocellular carcinoma
标题 作者 时间 类型 操作
A genome-wide association study of five meat quality traits in Yorkshire pigs
Qian DONG,Huiying LIU,Xinyun LI,Wei WEI,Shuhong ZHAO,Jianhua CAO
期刊论文
Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies
null
期刊论文
Genome-wide association study of the backfat thickness trait in two pig populations
Dandan ZHU,Xiaolei LIU,Rothschild MAX,Zhiwu ZHANG,Shuhong ZHAO,Bin FAN
期刊论文
Genome-wide association analysis reveals genetic loci and candidate genes associated with intramuscular
Xingwang WANG, Rongrong DING, Jianping QUAN, Linxue YANG, Ming YANG, Enqin ZHENG, Dewu LIU, Gengyuan CAI, Zhenfang WU, Jie YANG
期刊论文
Genetic Study Identifies CBLN4 as a Novel Susceptibility Gene for Accident Proneness
Shu-lin Zhang,Hui-qing Jin,Yang Song,Wan-sheng Yu,Liang-dan Sun
期刊论文
U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-controlstudy in Chinese population
null
期刊论文
Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction
Hong LI,Ziding ZHANG
期刊论文
Transcriptome resources and genome-wide marker development for Japanese larch (
Wanfeng LI,Suying HAN,Liwang QI,Shougong ZHANG
期刊论文
Development of Machine Learning Methods for Accurate Prediction of Plant Disease Resistance
Qi Liu,Shi-min Zuo,Shasha Peng,Hao Zhang,Ye Peng,Wei Li,Yehui Xiong,Runmao Lin,Zhiming Feng,Huihui Li,Jun Yang,Guo-Liang Wang,Houxiang Kang,
期刊论文
Genome-wide search for candidate genes determining vertebrae number in pigs
Longchao ZHANG, Jingwei YUE, Xin LIU, Jing LIANG, Kebin ZHAO, Hua YAN, Na LI, Lei PU, Yuebo ZHANG, Huibi SHI, Ligang WANG, Lixian WANG
期刊论文
Genome-wide identification and expression analysis of the β-amylase genes strongly associated with fruit
Hongxia MIAO,Peiguang SUN,Yulu MIAO,Juhua LIU,Jianbin ZHANG,Caihong JIA,Jingyi WANG,Zhuo WANG,Zhiqiang JIN,Biyu XU
期刊论文
A post-GWAS replication study confirming the association of
Shaohua YANG,Chao QI,Yan XIE,Xiaogang CUI,Yahui GAO,Jianping JIANG,Li JIANG,Shengli ZHANG,Qin ZHANG,Dongxiao SUN
期刊论文