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黄培,黄勋彬
《中国工程科学》 2015年 第17卷 第6期 页码 16-20
复方口服避孕药（combined oral contraceptives，COCs）由外源性雌孕激素配伍而成，主要是通过高于生理水平的雌孕激素负反馈抑制垂体-卵巢轴，降低内源性促性腺激素和性激素的水平但在周期性的COCs的无活性药间期（hormone-free interval， HFI）会有垂体-卵巢轴活性的恢复，其激素水平的变化及卵泡发育的情况与雌激素的剂量、孕激素的剂型、HFI的改变相关。
月经周期中免疫球蛋白G N-糖基化的周期性变化 Article
Julija Jurić, Hongli Peng, Manshu Song, Frano Vučković, Jelena Šimunović, Irena Trbojević-Akmačić, Youxin Wang, Jiaonan Liu, Qing Gao, Hao Wang, Qiaoyun Chu, Marija Pezer, Wei Wang, Gordan Lauc
《工程（英文）》 2023年 第26卷 第7期 页码 108-118 doi: 10.1016/j.eng.2022.10.020
Immunoglobulin G (IgG) is the most abundant plasma glycoprotein and a prominent humoral immune mediator. Glycan composition affects the affinity of IgG to ligands and consequent immune responses. The modification of IgG N-glycosylation is considered to be one of the various mechanisms by which sex hormones modulate the immune system. Although the menstrual cycle is the central sex hormone-related physiological process in most women of reproductive age, IgG N-glycosylation dynamics during the menstrual cycle have not yet been investigated. To fill this gap, we profiled the plasma IgG N-glycans of 70 healthy premenopausal women at 12 time points during their menstrual cycles (every 7 days for 3 months) using hydrophilic interaction ultra-performance liquid chromatography (HILIC-UPLC). We observed cyclic periodic changes in the N-glycosylation of IgG in association with the menstrual cycle phase and sex hormone concentration in plasma. On the integrated cohort level, the modeled average menstrual cycle effect on the abundance of IgG N-glycosylation traits was low for each trait, with the highest being 1.1% for agalactosylated N-glycans. However, intrapersonal changes were relatively high in some cases; for example, the largest difference between theminimum and maximum values during themenstrual cycle was up to 21% for sialylated N-glycans. Across all measurements, the menstrual cycle phase could explain up to 0.72% of the variation in the abundance of a single IgG glycosylation trait of monogalactosylation. In contrast, up to 99% of the variation in the abundance of digalactosylation could be attributed to interpersonal differences in IgG N-glycosylation. In conclusion, the average extent of changes in the IgG N-glycopattern that occur during the menstrual cycle is small; thus, the IgG N-glycoprofiling of women in large sample-size studies can be performed regardless of menstrual cycle phase.
周丹妮,杨菁,吴庚香,李赛姣,余楠,赵萌,文妍琪
《中国工程科学》 2014年 第16卷 第5期 页码 79-84
探究体外受精—胚胎移植/单精子卵泡浆内注射-胚胎移植（IVF/ICSI）患者注射人绒毛膜促性腺激素（HCG）日血清雌孕激素水平对妊娠结局的影响比较两组间的女方年龄、不孕年限、基础卵泡刺激素（FSH）值、促性腺激素（Gn）天数、Gn用量、获卵数、MII 卵数、受精数、卵裂数、优胚数、移植数、E2值、临床妊娠率、胚胎着床率。
关键词： 孕酮值 HCG日 IVF/ICSI 新鲜周期 临床妊娠率
多囊卵巢综合征无排卵的胰岛素信号和雄激素合成的新遗传风险和代谢特征 Article
吴效科, 黄志超, 曹义娟, 李建, 李志强, 马红丽, 高敬书, 常惠, 张多加, 丛晶, 王宇, 吴奇, Xiaoxiao Han, Pui Wah Jacqueline Chung, Yiran Li, Xu Zheng, Lingxi Chen, Lin Zeng, Astrid Borchert, Hartmut Kuhn, Zi-Jiang Chen, Ernest Hung Yu Ng, Elisabet Stener-Victorin, 张和平, Richard S. Legro, Ben Willem J. Mol, 师咏勇
《工程（英文）》 2023年 第23卷 第4期 页码 103-111 doi: 10.1016/j.eng.2022.08.013
标题 作者 时间 类型 操作
月经周期中免疫球蛋白G N-糖基化的周期性变化
Julija Jurić, Hongli Peng, Manshu Song, Frano Vučković, Jelena Šimunović, Irena Trbojević-Akmačić, Youxin Wang, Jiaonan Liu, Qing Gao, Hao Wang, Qiaoyun Chu, Marija Pezer, Wei Wang, Gordan Lauc
期刊论文
多囊卵巢综合征无排卵的胰岛素信号和雄激素合成的新遗传风险和代谢特征
吴效科, 黄志超, 曹义娟, 李建, 李志强, 马红丽, 高敬书, 常惠, 张多加, 丛晶, 王宇, 吴奇, Xiaoxiao Han, Pui Wah Jacqueline Chung, Yiran Li, Xu Zheng, Lingxi Chen, Lin Zeng, Astrid Borchert, Hartmut Kuhn, Zi-Jiang Chen, Ernest Hung Yu Ng, Elisabet Stener-Victorin, 张和平, Richard S. Legro, Ben Willem J. Mol, 师咏勇
期刊论文
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