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ω-Amine Transaminase AtATA for Overcoming the Trade-Off between Activity and Stability Toward 1- Article

Jiaren Cao, Fangfang Fan, Changjiang Lyu, Sheng Hu, Weirui Zhao, Jiaqi Mei, Shuai Qiu, Lehe Mei, Jun Huang

Engineering 2023, Volume 30, Issue 11,   Pages 203-214 doi: 10.1016/j.eng.2023.04.009

Abstract: We discovered a structural switch comprising four key amino acid sites (R128, V149, L182, and L187), is 1.7 mmol·L–1) and half-life (t1/2) by 59-fold to5.9 L·min–1·mmol–1 and by 1.6-fold to 46.9 min, respectively1-acetonaphthone in a 50 mL scaledup system to the desired product, (R)-(+)-1(1-naphthyl)ethylamine((R)-NEA), with 78% yield and high enantiomeric purity (R > 99.5%) within 10 h.

Keywords： Trade-off     Co-evolution     Amine transaminase     (R)-(+)-1(1-naphthyl)ethylamine    

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Microwave-assisted synthesis and antimicrobial activities of 2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin

Hua CHEN, Yanan LI, Jie BAI, Lian ZHAO, Xiangguo YUAN, Xiaoliu LI, Keqiang CAO

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 2,   Pages 186-191 doi: 10.1007/s11705-009-0004-0

Abstract: 2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin-4-ones and were synthesized in 41%-67% yield by

Keywords： microwave-assisted synthesis     naphthyl     thiazolidin-4-one     antimicrobial    

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PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 399-403 doi: 10.1007/s11684-014-0380-9

Abstract: review here the novel cardiac protective effects of the multifunctional enzyme, p21-activated kinase 1(PAK1), a member of a serine/threonine protein kinase family.Despite the large body of evidence from studies in noncardiac tissue indicating that PAK1 activity iskey in the regulation of a number of cellular functions, the role of PAK1 in the heart has only beenWe discuss the anti-adrenergic and antihypertrophic cardiac protective effects of PAK1, as well as its

Keywords： p21-activated kinase 1 (PAK1)     heart    

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Hot deformation behavior of a novel bimetal consisting of BTW1 and Q345R characterized by processing

Pengtao LIU, Lifeng MA, Weitao JIA, Tao WANG, Guanghui ZHAO

Frontiers of Mechanical Engineering 2019, Volume 14, Issue 4,   Pages 489-495 doi: 10.1007/s11465-019-0554-x

Abstract: Only a few studies have been conducted on the flow behavior of the novel BTW1/Q345R bimetal, which isIn this work, compression tests were conducted on BTW1/Q345R bimetal at a temperature range of 950 °CThe computed apparent activation energy of the BTW1/Q345R bimetal was 360 kJ/mol, and processing mapsQ345R bimetal.Results showed that thermal deformation of the BTW1/Q345R bimetal should proceed when the temperature

Keywords： BTW1/Q345R bimetal     constitutive equation     processing map     work hardening    

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Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 36-40 doi: 10.1007/s11684-009-0020-y

Abstract: (AT1R) in hepatic stellate cells (HSCs)The mRNA expression of AT1R at 4, 12 and 24 h after treatment was detected by reverse transcription-polymeraseThe protein expression of AT1R was detected by western blot.( <0.05), but 10 mg/L β-elemene had no such effect. β-elemene significantly reduced the amount of AT1RThe expression of AT1R protein also decreased after the treatment with β-elemene for 24 h. β-elemene

Keywords： liver cirrhosis     beta-elemene     hepatic stellate cells     angiotensin II     receptor     angiotensin     type 1    

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Non-iterative parameter estimation of the 2R-1Cmodel suitable for low-cost embedded hardware Article

Mitar SIMIĆ, Zdenka BABIĆ, Vladimir RISOJEVIĆ, Goran M. STOJANOVIĆ

Frontiers of Information Technology & Electronic Engineering 2020, Volume 21, Issue 3,   Pages 476-490 doi: 10.1631/FITEE.1900112

Abstract: Parameter estimation of the 2R-1C model is usually performed using iterative methods that require high-performanceThe 2R-1C model parameters are subsequently calculated from the real and imaginary parts of the measuredComparative analysis conducted on the impedance data of the 2R-1C model obtained in both simulation andMoreover, we compared the QINIPE and the complex nonlinear least squares (CNLS) estimation of the 2R-1C model parameters.

Keywords： 2R-1C model     Embedded systems     Parameter estimation     Non-iterative methods     Quadratic interpolation    

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Analysis of GM（1，1）Model and Its Application in Fire Risk Prediction

Chen Zijin,Wang Fuliang,Lu Shouxiang

Strategic Study of CAE 2007, Volume 9, Issue 5,   Pages 91-94

Abstract:

Theoretical analysis of grey prediction model GM(1, 1) is present inMonotonicity of predicted value and its variation tendency predicted by GM(1, 1)model is proved.the monotonicity of predicted value and its variation tendency,  applicability criterion of GM(1,1) is brought forward.

Keywords： fire forecast     GM(1     1)     rate of the fire injured    

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Constant-gain nonlinear adaptive observers revisited: an application to chemostat systems Research Articles

Torres, Arno Sonck, Sergej Čelikovský, Alma R.

Frontiers of Information Technology & Electronic Engineering 2021, Volume 22, Issue 1,   Pages 1-140 doi: 10.1631/FITEE.2000368

Abstract: This study deals with constant-gain for nonlinear systems, for which relatively few solutions are available for some particular cases. We introduce an asymptotic observer of constant gain for nonlinear systems that have linear input. This allows the observer design to be formulated within the linear matrix inequality paradigm provided that a strictly positive real condition between the input disturbance and the output is fulfilled. The proposed observer is then applied to a large class of nonlinear dynamical systems that are widely used in the fermentation process, cell cultures, medicine, etc. In fact, under standard practical assumptions, the necessary change of the state coordinates exists, allowing use of the constant-gain observer. Finally, the developed theory is illustrated by estimating pollutant concentration in a wastewater treatment facility.

Keywords： Nonlinear observers     Adaptive observers     Coordinate change     Chemostat     Pollutant observation    

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Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Frontiers of Medicine   Pages 805-822 doi: 10.1007/s11684-023-1025-7

Abstract: To date, immune checkpoint inhibitors (ICIs) of CTLA-4 and PD-1/PD-L1 represent the main class of immunotherapyBlockade of CTLA-4 and PD-1/PD-L1 has shown remarkable efficacy in several specific types of cancers,generalized mechanism of targeting cancer metabolism at three crucial immune checkpoints (CTLA-4, PD-1,and PD-L1) to influence ICB therapy and propose potential combined immunotherapeutic strategies co-targeting

Keywords： CTLA-4     PD-1     PD-L1     immune checkpoint blockade (ICB)     metabolic reprogramming     combined tumor therapeutic    

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geological recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-1

Deng Yunhua

Strategic Study of CAE 2011, Volume 13, Issue 10,   Pages 13-18

Abstract: According to this guidance, such giant oilfield JX1-1 was discovered with 150 million reserves in the

Keywords： Bohai Liaodong zone     JX1-1     geological recognition     large oilfield    

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Federated unsupervised representation learning Research Article

Fengda ZHANG, Kun KUANG, Long CHEN, Zhaoyang YOU, Tao SHEN, Jun XIAO, Yin ZHANG, Chao WU, Fei WU, Yueting ZHUANG, Xiaolin LI,fdzhang@zju.edu.cn,kunkuang@zju.edu.cn

Frontiers of Information Technology & Electronic Engineering 2023, Volume 24, Issue 8,   Pages 1181-1193 doi: 10.1631/FITEE.2200268

Abstract: FURL poses two new challenges: (1) data distribution shift (non-independent and identically distributed

Keywords： Federated learning     Unsupervised learning     Representation learning     Contrastive learning    

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Non-equidistant GM(1,1) power model and its application in engineering

Wang Zhengxin,Dang Yaoguo,Liu Sifeng

Strategic Study of CAE 2012, Volume 14, Issue 7,   Pages 98-102

Abstract: text-align: justify;">Aiming at the problem of modeling for non-equidistant sequence, the non-equidistant GM(1,1The results showed that the form of non equidistant GM(1,1) power model was more flexible than the traditionalBoth non equidistant GM(1,1) model and Grey Verhulst model were the special cases of non equidistantGM(1,1) power model.shows modeling accuracy in traditional modeling, which was significantly improved by non equidistant GM(1,1

Keywords： grey system     non-equidistant sequence     GM(1     1) power model     parameter optimization    

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Band-gap tunable (GaxIn1−x)2O3 layer Research Articles

Fabi Zhang, Jinyu Sun, Haiou Li, Juan Zhou, Rong Wang, Tangyou Sun, Tao Fu, Gongli Xiao, Qi Li, Xingpeng Liu, Xiuyun Zhang, Daoyou Guo, Xianghu Wang, Zujun Qin,zhangfabi@outlook.com,qinzj@guet.edu.cn

Frontiers of Information Technology & Electronic Engineering 2021, Volume 22, Issue 10,   Pages 1370-1378 doi: 10.1631/FITEE.2000330

Abstract: Multicomponent oxide (GaIn)O films are prepared on (0001) sapphire substrates to realize a tunable band-gap by technology followed by thermal annealing. The optical properties and band structure evolution over the whole range of compositions in ternary compounds (GaIn)O are investigated in detail. The X-ray diffraction spectra clearly indicate that (GaIn)O films with Ga content varying from 0.11 to 0.55 have both cubic and monoclinic structures, and that for films with Ga content higher than 0.74, only the monoclinic structure appears. The transmittance of all films is greater than 86% in the visible range with sharp absorption edges and clear fringes. In addition, a blue shift of ultraviolet absorption edges from 380 to 250 nm is noted with increasing Ga content, indicating increasing band-gap energy from 3.61 to 4.64 eV. The experimental results lay a foundation for the application of transparent conductive compound (GaIn)O thin films in photoelectric and photovoltaic industry, especially in display, light-emitting diode, and solar cell applications.

Keywords： (GaxIn1−x)2O3薄膜；带隙可调谐；磁控溅射    

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Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis

Changlin Cao, Jingxian Gu, Jingyao Zhang

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 169-177 doi: 10.1007/s11684-017-0505-z

Abstract: An example of these biomarkers is triggering receptor expressed on myeloid cell-1 (TREM-1), which isTREM-1 amplifies inflammation by activating the TREM-1/DAP12 pathway.Soluble TREM-1 (sTREM-1) is a special form of TREM-1 that can be directly tested in human body fluidsand well-known biomarker for infectious diseases. sTREM-1 level can be potentially used for the earlyTherefore, sTREM-1 is a feasible biomarker for the targeted therapy and rapid and early diagnosis of

Keywords： soluble triggering receptor expressed on myeloid cells-1     infectious diseases     diagnosis and prognosis    

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Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 73-83 doi: 10.15302/J-FASE-2015044

Abstract: Suppressor of cytokine signaling 1 (SOCS1) protein can inhibit the signal transduction triggered by someamino acid protein, which shares high amino acid sequence identity (64%–67%) with human and mouse SOCS1.and cSOCS1a.and SOCS1b proteins can negatively regulate GH/PRL signaling.Taken together, these data suggest that both cSOCS1a and cSOCS1b may function as negative regulators

Keywords： chicken     SOCS1a     SOCS1b     growth hormone     prolactin    

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Title Author Date Type Operation

ω-Amine Transaminase AtATA for Overcoming the Trade-Off between Activity and Stability Toward 1-

Jiaren Cao, Fangfang Fan, Changjiang Lyu, Sheng Hu, Weirui Zhao, Jiaqi Mei, Shuai Qiu, Lehe Mei, Jun Huang

Journal Article

Microwave-assisted synthesis and antimicrobial activities of 2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin

Hua CHEN, Yanan LI, Jie BAI, Lian ZHAO, Xiangguo YUAN, Xiaoliu LI, Keqiang CAO

Journal Article

PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Journal Article

Hot deformation behavior of a novel bimetal consisting of BTW1 and Q345R characterized by processing

Pengtao LIU, Lifeng MA, Weitao JIA, Tao WANG, Guanghui ZHAO

Journal Article

Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

Journal Article

Non-iterative parameter estimation of the 2R-1Cmodel suitable for low-cost embedded hardware

Mitar SIMIĆ, Zdenka BABIĆ, Vladimir RISOJEVIĆ, Goran M. STOJANOVIĆ

Journal Article

Analysis of GM（1，1）Model and Its Application in Fire Risk Prediction

Chen Zijin,Wang Fuliang,Lu Shouxiang

Journal Article

Constant-gain nonlinear adaptive observers revisited: an application to chemostat systems

Torres, Arno Sonck, Sergej Čelikovský, Alma R.

Journal Article

Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Journal Article

geological recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-recognition breakthrough in Liaodong zone, which leading to the discovery of the large oilfield JX1-1

Deng Yunhua

Journal Article

Federated unsupervised representation learning

Fengda ZHANG, Kun KUANG, Long CHEN, Zhaoyang YOU, Tao SHEN, Jun XIAO, Yin ZHANG, Chao WU, Fei WU, Yueting ZHUANG, Xiaolin LI,fdzhang@zju.edu.cn,kunkuang@zju.edu.cn

Journal Article

Non-equidistant GM(1,1) power model and its application in engineering

Wang Zhengxin,Dang Yaoguo,Liu Sifeng

Journal Article

Band-gap tunable (GaxIn1−x)2O3 layer

Fabi Zhang, Jinyu Sun, Haiou Li, Juan Zhou, Rong Wang, Tangyou Sun, Tao Fu, Gongli Xiao, Qi Li, Xingpeng Liu, Xiuyun Zhang, Daoyou Guo, Xianghu Wang, Zujun Qin,zhangfabi@outlook.com,qinzj@guet.edu.cn

Journal Article

Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis

Changlin Cao, Jingxian Gu, Jingyao Zhang

Journal Article

Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Journal Article