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Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property, a requisite of leukemia initiation and relapse

Yuting Tan,Han Liu,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 4, Pages 412-420 doi: 10.1007/s11684-015-0423-x

Abstract: Recent research on DNA methyltransferase 3A (DNMT3A) mutations provides the first proof-of-principleAlthough DNMT3A mutations alone may only transform hematopoietic stem cells into pre-LSCs without causingTherefore, identifying and targeting preleukemic mutations, such as DNMT3A mutations, in AML is a promising

Keywords： preleukemic stem cell acute myeloid leukemia relapse DNMT3A

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Effect on proliferation and apoptosis of T24 cell lines via silencing DNMT1 with RNA interference

ZHANG Shilong, ZENG Fuqing, PENG Shibo, WANG Liang

Frontiers of Medicine 2008, Volume 2, Issue 4, Pages 374-379 doi: 10.1007/s11684-008-0072-4

Abstract: Expression of DNA methyltransferase 1 (DNMT1), which plays an important role on aberrantly methylatedIn this study, the eukaryotic vector pshRNA-DNMT1 was constructed and transfected into T24 cells.inhibitory rates of DNMT1 mRNA levels in T24 cells were 28.44%, 52.48%, 70.91%, respectively.Those of DNMT1 proteins were 24.27%, 57.79%, and 77.74%, respectively.The growth inhibition rates of pshRNA-DNMT1 at the 24th, 48th and 72nd hour after transfection of pshRNA-DNMT1

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Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational study

Frontiers of Medicine doi: 10.1007/s11684-023-1016-8

Abstract: In a retrospective study on tissue microarrays with 132 TNBC cases, DNMT1 overexpression was associatedpatients with available TP53 sequencing results, the 6 patients with p53 mutations had higher ORR (3/6 vs. 0/3) and better OS (16.0 vs. 4.0 months) than the patients with wild-type p53.mechanistic study, isogenic TNBC cell lines harboring DETECT-derived p53 mutations exhibited higher DNMT1

Keywords： p53 mutation triple-negative breast cancer decitabine DNMT1 IRF7 innate immune response

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Xiaohan: Traditional Chinese Medicine Talks About Health, Dietary Supplement and Improving Immunity (2020-3-

18 Apr 2022

Keywords：营养健康

Synthesis of copolymers of 3-acryloyloxymethyl-3′-methyloxetane and 3-(2-(2-(2-Methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane and their ionic conductivity properties

YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng

Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 4, Pages 343-348 doi: 10.1007/s11705-007-0062-0

Abstract: An oxetane-derived monomer, 3-acryloyloxymethyl-3′-methyloxetane (AMO) was prepared from the reactionof 3-hydromethyl-3-methyloxetane with acryloyl chloride.The cationic ring-opening copolymerization of AMO with another oxetane-derived monomer, 3-(2-(2-(2-methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane (MEMO) was conducted in CHCl solution using BF3 ·OEt/1, 4-butanediol

Keywords： 4-butanediol 2-methoxyethylenoxy consistent oxetane-derived copolymer

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Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

Frontiers of Medicine 2008, Volume 2, Issue 1, Pages 95-99 doi: 10.1007/s11684-008-0017-y

Abstract: The Sj14-3-3 gene was amplified and subcloned into the expression vector pPICZ?The protein of rSj14-3-3 was prepared and purified and BALB/c mice were immunized which was followedThe Sj14-3-3 gene was expressed and secreted into the medium and its molecular weight was about 35000antibody and rSj14-3-3 had a promising immune reactivity.The recombinant Sj14-3-3 of eukaryotic expression in was successfully harvested.

Keywords： development challenging rSj14-3-3 resistance cultural supernatant

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第四届高性能编译、计算和通信国际会议(HP3C 2020)

Conference Date: 12 Mar 2020

Conference Place: 广东广州

Administered by: HP3C 2020

FOXP3 and Its Cofactors as Targets of Immunotherapies Review

Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang

Engineering 2019, Volume 5, Issue 1, Pages 115-121 doi: 10.1016/j.eng.2019.01.001

Abstract:

Forkhead box P3 (FOXP3) is a "master regulator" of regulatory T cells (Tregs), which areAs a consequence, the PTMs change the stability of FOXP3 and its capability to regulate gene expressionAlthough FOXP3 per se is not an ideal drug target, deacetylases, acetyltransferases, kinases, and other enzymes that regulate the PTMs of FOXP3 are potential targets to modulate FOXP3 and TregFOXP3" side effects must be considered when inhibitors to these enzymes are used.

Keywords： Treg Forkhead box P3 (FOXP3) Post-translational modification Autoimmune Cancer

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Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and

Frontiers of Medicine doi: 10.1007/s11684-023-1003-0

Abstract: However, little is known about the function of Lipin3 in triglyceride (TG) metabolism.Hence, we generated Lipin3 heterozygous knockout (Lipin3-heKO) mice and cultured primary hepatocytesto explore the pathophysiological roles of Lipin3 in TG metabolism.Our study suggested that Lipin3 was a novel disease-causing gene inducing obesity and HTG.We also established a relationship between Lipin3 and mitochondrial dysfunction.

Keywords： Lipin3 Lipin1 hypertriglyceridemia obesity mitochondrial dysfunction

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A Review on the 3D Printing of Functional Structures for Medical Phantoms and Regenerated Tissue and

Kan Wang, Chia-Che Ho, Chuck Zhang, Ben Wang

Engineering 2017, Volume 3, Issue 5, Pages 653-662 doi: 10.1016/J.ENG.2017.05.013

Abstract: With the rapid advancement of three-dimensional (3D) printing and 3D bioprinting technologies, many researchersThis paper reviews the applications of these 3D printing and 3D bioprinting technologies for the fabricationThis review specifically discusses the state of the art along with new developments and trends in 3Dmedical phantoms, radiologically relevant medical phantoms, and physiological medical phantoms) and 3D

Keywords： 3D printing 3D bioprinting Medical phantom Regenerated tissue/organ Scaffold

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2020第四届环境与能源工程国际会议(IC3E 2020)

Conference Date: 12 Mar 2020

Conference Place: 海南海口三亚

Administered by: APISE

Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Frontiers of Medicine 2007, Volume 1, Issue 3, Pages 269-273 doi: 10.1007/s11684-007-0051-1

Abstract: investigate the influence and the related mechanism of the gene on glucose uptake and insulin resistance in 3T3Radioimmunoassay was used to determine glucose uptake in 3T3-L1 cells with different gene expressionreal-time RT-PCR analysis were used to determine the mRNA levels of several glucose transport proteins in 3T3and glycogen synthase kinase-3b (GSK-3)., GSK-3 and p38MAPK, increased with overexpression in 3T3-L1 cells.

Keywords： 3T3-L1 influence resistance receptor substrate-1 transport

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Combustion and emissions of RP-3 jet fuel and diesel fuel in a single-cylinder diesel engine

Frontiers in Energy 2023, Volume 17, Issue 5, Pages 664-677 doi: 10.1007/s11708-021-0787-3

Abstract: The combustion characteristics and emission behaviors of RP-3 jet fuel were studied and compared to commercialcrank angle (CA) after top dead center (ATDC)) were adjusted to evaluate the engine performances of RP-3In comparison to diesel fuel, RP-3 jet fuel shows a retarded heat release and lagged combustion phaseAs a result, RP-3 jet fuel features a longer ignition delay (ID) time, a shorter combustion durationCompared with diesel fuel, the nitrogen oxides (NO_x) emissions of RP-3 jet fuel are

Keywords： RP-3 jet fuel diesel engine combustion emissions

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China Engineering Science 2001 Volume 3 Contents

Strategic Study of CAE 2001, Volume 3, Issue 12, Pages 96-99

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Overoxidized poly(3,4-ethylenedioxythiophene)-overoxidized polypyrrole composite films with enhanced

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 6, Pages 735-748 doi: 10.1007/s11705-022-2262-z

Abstract: simple and effective method was proposed to improve the electrocatalytic ability of overoxidized poly(3,4

Keywords： overoxidized poly(3 4-ethylenedioxythiophene)-overoxidized polypyrrole rutin luteolin incubation

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Title Author Date Type Operation

Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property, a requisite of leukemia initiation and relapse

Yuting Tan,Han Liu,Saijuan Chen

Journal Article

Effect on proliferation and apoptosis of T24 cell lines via silencing DNMT1 with RNA interference

ZHANG Shilong, ZENG Fuqing, PENG Shibo, WANG Liang

Journal Article

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational study

Journal Article

Xiaohan: Traditional Chinese Medicine Talks About Health, Dietary Supplement and Improving Immunity (2020-3-

18 Apr 2022

Conference Videos

Synthesis of copolymers of 3-acryloyloxymethyl-3′-methyloxetane and 3-(2-(2-(2-Methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane and their ionic conductivity properties

YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng

Journal Article

Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

Journal Article

第四届高性能编译、计算和通信国际会议(HP3C 2020)

12 Mar 2020

Conference Information

FOXP3 and Its Cofactors as Targets of Immunotherapies

Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang

Journal Article

Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and