Resource Type

Journal Article 11

Year

2021 1

2020 1

2019 5

2018 1

2014 2

2013 1

Keywords

Biomarkers 4

biomarkers 2

metabolomics 2

Biological diversity 1

CAR19 1

CART19 1

Chimeric antigen receptor 1

Chinmedomics 1

Chlorinated solvents 1

Coupled treatments 1

Diethylene ether 1

Drug development process 1

Early detection 1

Efficacy 1

Engineered T cell therapies 1

HCC 1

Hepatocellular carcinoma 1

IDH1 1

Liquid biopsy 1

MGMT 1

open ︾

Search scope:

排序： Display mode:

Sepsis biomarkers: an omics perspective

Xiao Liu, Hui Ren, Daizhi Peng

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 58-67 doi: 10.1007/s11684-014-0318-2

Abstract: Omics technologies allow high-throughput screening of sepsis biomarkers.This review describes currently available and novel sepsis biomarkers in the context of genomics, transcriptomics

Keywords： sepsis     biomarker     genomics     transcriptomics     proteomics     metabolomics    

HTML PDF Collect

Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets

Feng Wang,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 404-418 doi: 10.1007/s11684-014-0379-2

Abstract: This has raised the possibility of using circulating miRNAs as biomarkers for diseases., we discuss the potential roles of circulating miRNAs in a variety of cardiovascular diseases from biomarkers

Keywords： microRNA     cardiovascular disease     biomarkers     therapeutic target    

HTML PDF Collect

Progress on molecular biomarkers and classification of malignant gliomas

Chuanbao Zhang, Zhaoshi Bao, Wei Zhang, Tao Jiang

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 150-156 doi: 10.1007/s11684-013-0267-1

Abstract: Several diagnostic, predictive, and prognostic biomarkers for malignant gliomas have been reported overIn this review, we summarize three distinctive biomarkers, three most commonly altered pathways, and

Keywords： malignant glioma     molecular biomarker     IDH1     MGMT     molecular classification    

HTML PDF Collect

Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases

Zhen Xiang, Yingyan Yu

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 24-31 doi: 10.1007/s11684-019-0679-7

Abstract: Omnibus, provide large volumes of data, which allow researchers to explore responsive or resistant biomarkers

Keywords： immune checkpoint blockade     sensitivity     resistance     data mining    

HTML PDF Collect

Post-surgical resection prognostic value of combined OPN, MMP7, and PSG9 plasma biomarkers in hepatocellular

Weiqi Rong, Yang Zhang, Lei Yang, Lin Feng, Baojun Wei, Fan Wu, Liming Wang, Yanning Gao, Shujun Cheng, Jianxiong Wu, Ting Xiao

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 250-258 doi: 10.1007/s11684-018-0632-1

Abstract: Biomarkers for hepatocellular carcinoma (HCC) following curative resection are not currently sufficient

Keywords： biomarkers     OPN     MMP7     PSG9     HCC     prognosis    

HTML PDF Collect

Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy

Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 32-44 doi: 10.1007/s11684-018-0678-0

Abstract: Therefore, doctors urgently need reliable predictive biomarkers for checkpoint inhibitor therapies toHere, we review the biomarkers that can serve as potential predictors of the outcomes of immune checkpoint

Keywords： immune checkpoint     companion diagnosis     PD-L1     tumor mutation burden     immune score    

HTML PDF Collect

High-throughput metabolomics reveals the perturbed metabolic pathways and biomarkers of Yang Huang syndrome

Heng Fang, Aihua Zhang, Xiaohang Zhou, Jingbo Yu, Qi Song, Xijun Wang

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 651-663 doi: 10.1007/s11684-019-0709-5

Abstract: High-throughput metabolomics can clarify the underlying molecular mechanism of diseases via the qualitative and quantitative analysis of metabolites. This study used the established Yang Huang syndrome (YHS) mouse model to evaluate the efficacy of geniposide (GEN). Urine metabolic data were quantified by ultra-performance liquid chromatography–tandem mass spectrometry. The non-target screening of the massive biological information dataset was performed, and a total of 33 metabolites, including tyramine glucuronide, aurine, and L-cysteine, were identified relating to YHS. These differential metabolites directly participated in the disturbance of phase I reaction and hydrophilic transformation of bilirubin. Interestingly, they were completely reversed by GEN. While, as the auxiliary technical means, we also focused on the molecular prediction and docking results in network pharmacological and integrated analysis part. We used integrated analysis to communicate the multiple results of metabolomics and network pharmacology. This study is the first to report that GEN indirectly regulates the metabolite “tyramine glucuronide” through its direct effect on the target heme oxygenase 1 . Meanwhile, heme oxygenase-1, a prediction of network pharmacology, was the confirmed metabolic enzyme of phase I reaction in hepatocytes. Our study indicated that the combination of high-throughput metabolomics and network pharmacology is a robust combination for deciphering the pathogenesis of the traditional Chinese medicine (TCM) syndrome.

Keywords： metabolomics     liquid chromatography-mass spectrometry     metabolites     metabolic pathways    

HTML PDF Collect

Novel Non-Protein Biomarkers for Early Detection of Hepatocellular Carcinoma Review

Ghassan K. Abou-Alfa, Lin Wu, Augusto Villanueva

Engineering 2021, Volume 7, Issue 10,   Pages 1369-1374 doi: 10.1016/j.eng.2021.02.020

Abstract: However, highly sensitive and specific surveillance biomarkers for early-stage HCC detection are still

Keywords： Hepatocellular carcinoma     Early detection     Biomarkers     Liquid biopsy    

HTML PDF Collect

Engineered T Cell Therapies from a Drug Development Viewpoint Review

Fang Chen, Joseph A. Fraietta, Carl H. June, Zhongwei Xu, J. Joseph Melenhorst, Simon F. Lacey

Engineering 2019, Volume 5, Issue 1,   Pages 140-149 doi: 10.1016/j.eng.2018.11.010

Abstract: and computational tools that enable the discovery of optimal targets, novel CAR binding domains, and biomarkers

Keywords： Engineered T cell therapies     Chimeric antigen receptor     Drug development process     Biomarkers     CAR19    

HTML PDF Collect

Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the Efficacy of Traditional Chinese Medicine Review

Ai-Hua Zhang, Hui Sun, Guang-Li Yan, Ying Han, Qi-Qi Zhao, Xi-Jun Wang

Engineering 2019, Volume 5, Issue 1,   Pages 60-68 doi: 10.1016/j.eng.2018.11.008

Abstract: were integrated to establish an innovative chinmedomics strategy, which is able to explore syndrome biomarkersThis article summarizes the application of chinmedomics in identifying the candidate biomarkers of a

Keywords： Chinmedomics     Serum pharmacochemistry of TCM     Efficacy     Metabolomics     Syndrome     Biomarkers     Quality markers    

HTML PDF Collect

Microbial responses to combined oxidation and catalysis treatment of 1,4-dioxane and co-contaminants in groundwater and soil

Yu Miao, Nicholas W. Johnson, Kimberly Heck, Sujin Guo, Camilah D. Powell, Thien Phan, Phillip B. Gedalanga, David T. Adamson, Charles J. Newell, Michael S. Wong, Shaily Mahendra

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 5, doi: 10.1007/s11783-018-1071-6

Abstract:

Groundwater microbial community was altered after catalysis and chemical oxidation.

The coupled treatment train removed 90% 1,4-dioxane regardless of co-contaminants.

Dynamics of microbial populations varied along with different treatment stages.

Many microbial taxa exhibited resilience against oxidative and catalytic treatments.

Metagenomic analysis will be valuable for long-term management of polluted sites.

Keywords： Coupled treatments     Chlorinated solvents     Diethylene ether     Biological diversity     Microbial populations     Biomarkers    

HTML PDF Collect

Title Author Date Type Operation

Sepsis biomarkers: an omics perspective

Xiao Liu, Hui Ren, Daizhi Peng

Journal Article

Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets

Feng Wang,Chen Chen,Daowen Wang

Journal Article

Progress on molecular biomarkers and classification of malignant gliomas

Chuanbao Zhang, Zhaoshi Bao, Wei Zhang, Tao Jiang

Journal Article

Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases

Zhen Xiang, Yingyan Yu

Journal Article

Post-surgical resection prognostic value of combined OPN, MMP7, and PSG9 plasma biomarkers in hepatocellular

Weiqi Rong, Yang Zhang, Lei Yang, Lin Feng, Baojun Wei, Fan Wu, Liming Wang, Yanning Gao, Shujun Cheng, Jianxiong Wu, Ting Xiao

Journal Article

Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy

Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian

Journal Article

High-throughput metabolomics reveals the perturbed metabolic pathways and biomarkers of Yang Huang syndrome

Heng Fang, Aihua Zhang, Xiaohang Zhou, Jingbo Yu, Qi Song, Xijun Wang

Journal Article

Novel Non-Protein Biomarkers for Early Detection of Hepatocellular Carcinoma

Ghassan K. Abou-Alfa, Lin Wu, Augusto Villanueva

Journal Article

Engineered T Cell Therapies from a Drug Development Viewpoint

Fang Chen, Joseph A. Fraietta, Carl H. June, Zhongwei Xu, J. Joseph Melenhorst, Simon F. Lacey

Journal Article

Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the Efficacy of Traditional Chinese Medicine

Ai-Hua Zhang, Hui Sun, Guang-Li Yan, Ying Han, Qi-Qi Zhao, Xi-Jun Wang

Journal Article

Microbial responses to combined oxidation and catalysis treatment of 1,4-dioxane and co-contaminants in groundwater and soil

Yu Miao, Nicholas W. Johnson, Kimberly Heck, Sujin Guo, Camilah D. Powell, Thien Phan, Phillip B. Gedalanga, David T. Adamson, Charles J. Newell, Michael S. Wong, Shaily Mahendra

Journal Article