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xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research and a new co-clinicalmodel for treatment optimization

Shuyang Sun,Zhiyuan Zhang

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 104-110 doi: 10.1007/s11684-016-0432-4

Abstract: We also explore the translational value of this well-annotated PDX panel in the development of co-clinical

Keywords： patient-derived xenograft models     personalized medicine     co-clinical trial     patient stratification     oral    

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A study on specialist or special disease clinics based on big data

Zhuyuan Fang,Xiaowei Fan,Gong Chen

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 376-381 doi: 10.1007/s11684-014-0356-9

Abstract: This paper explores the concept of constructing a big medical data platform and introduces the clinicalmodel construction.Through analysis technology, such as artificial neural network and grey model, a medical model can bedecision-making model for specialist and special disease clinics.It establishes a new model for common clinical research for specialist and special disease clinics.

Keywords： big data     correlation analysis     medical information     integration     data analysis     clinical model    

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The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant

Frontiers of Medicine doi: 10.1007/s11684-022-0967-5

Abstract: In this study, we aim to elucidate the clinical impact and long-term course of tricuspid regurgitationMixed-models were used to model the evolution of TR.The mixed-model was inserted into a Cox model in order to address the association of the dynamic TR with

Keywords： orthotopic heart transplant     tricuspid regurgitation     clinical impact     biatrial heart transplantation    

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Ontological reconstruction of the clinical terminology of traditional Chinese medicine

Li Ma,Baoyan Liu,Qi Xie,Shusong Mao,Zhiwei Cui

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 358-361 doi: 10.1007/s11684-014-0348-9

Abstract:

This study proposes the ontological reconstruction of the current clinical terminology of traditionalof preliminary work related to the said reconstruction, including the ontology-based analysis of TCM clinicalWe conclude that the ontological reconstruction of TCM clinical terminology provides a proper translationfrom the idealized organizational model to real-world implementation and to a formalized, shared, and

Keywords： ontology     traditional Chinese medicine     clinical terminology    

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Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment

Tianhua Xu, Zitong Sheng, Li Yao

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 340-348 doi: 10.1007/s11684-017-0570-3

Abstract: A slow increase of subnephrotic proteinuria (<3.5 g/d) is the most common clinical manifestation of

Keywords： obesity-related glomerulopathy     pathogenesis     pathologic     clinical characteristics    

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Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

Frontiers of Medicine   Pages 551-573 doi: 10.1007/s11684-022-0928-z

Abstract: Patients with hepatocellular carcinoma (HCC) and bone metastasis (BM) suffer from greatly reduced life quality and a dismal prognosis. However, BM in HCC has long been overlooked possibly due to its relatively low prevalence in previous decades. To date, no consensus or guidelines have been reached or formulated for the prevention and management of HCC BM. Our narrative review manifests the increasing incidence of HCC BM to sound the alarm for additional attention. The risk factors, diagnosis, prognosis, and therapeutic approaches of HCC BM are detailed to provide a panoramic view of this disease to clinicians and specialists. We further delineate an informative cancer bone metastatic cascade based on evidence from recent studies and point out the main factors responsible for the tumor-associated disruption of bone homeostasis and the formation of skeletal cancer lesions. We also present the advances in the pathological and molecular mechanisms of HCC BM to shed light on translational opportunities. Dilemmas and challenges in the treatment and investigation of HCC BM are outlined and discussed to encourage further endeavors in the exploration of underlying pathogenic and molecular mechanisms, as well as the development of novel effective therapies for HCC patients with BM.

Keywords： HCC     bone     osteotropism     clinical     basic researches     advances    

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Design and Application of Clinical Big Data Management System for Oncology

Ma Lin, Bao Chenlu, Li Qing,Wu Jingyi, Pan Hong’an, Li Pengfei, Zhang Luxia, Zhan Qimin

Strategic Study of Chinese Academy of Engineering 2022, Volume 24, Issue 6,   Pages 127-136 doi: 10.15302/J-SSCAE-2022.06.011

Abstract: of medical informatization in China, healthcare institutions have cumulated a great quantity of clinicalHence, establishing a national clinical big data management system for oncology based on artificialthe quality and efficiency of clinical management for oncology.and application for oncology and presented the significant values of an oncology clinical datataking the clinical data management for lung cancer in a tertiary hospital as an example.

Keywords： clinical big data     management system     oncology     artificial intelligence     common data model     natural language    

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Coronavirus disease 2019 (COVID-19): a clinical update

Min Zhou, Xinxin Zhang, Jieming Qu

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 126-135 doi: 10.1007/s11684-020-0767-8

Abstract: promising antivirals, convalescent plasma transfusion, and tocilizumab needs to be investigated by ongoing clinical

Keywords： coronavirus disease 2019     epidemiology     pathology     radiology     clinical characteristics     treatment    

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Hypertension in patients with CKD in China: clinical characteristics and management

Guangyan Cai, Xiangmei Chen

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 307-309 doi: 10.1007/s11684-017-0578-8

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Biological properties and clinical applications of berberine

Danyang Song, Jianyu Hao, Daiming Fan

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 564-582 doi: 10.1007/s11684-019-0724-6

Abstract: Berberine, an isoquinoline alkaloid isolated from the Chinese herb and other plants, has a wide range of pharmacological properties. Berberine can be used to treat many diseases, such as cancer and digestive, metabolic, cardiovascular, and neurological diseases. Berberine has protective capacities in digestive diseases. It can inhibit toxins and bacteria, including , protect the intestinal epithelial barrier from injury, and ameliorate liver injury. Berberine also inhibits the proliferation of various types of cancer cells and impedes invasion and metastasis. Recent evidence has confirmed that berberine improves the efficacy and safety of chemoradiotherapies. In addition, berberine regulates glycometabolism and lipid metabolism, improves energy expenditure, reduces body weight, and alleviates nonalcoholic fatty liver disease. Berberine also improves cardiovascular hemodynamics, suppresses ischemic arrhythmias, attenuates the development of atherosclerosis, and reduces hypertension. Berberine shows potent neuroprotective effects, including antioxidative, antiapoptotic, and anti-ischemic. Furthermore, berberine exerts protective effects against other diseases. The mechanisms of its functions have been extensively explored, but much remains to be clarified. This article summarizes the main pharmacological actions of berberine and its mechanisms in cancer and digestive, metabolic, cardiovascular, and neurological diseases.

Keywords： berberine     Coptis chinensis     pharmacological properties     mechanism     clinical applications    

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Genetic and clinical markers for predicting treatment responsiveness in rheumatoid arthritis

Xin Wu, Xiaobao Sheng, Rong Sheng, Hongjuan Lu, Huji Xu

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 411-419 doi: 10.1007/s11684-018-0659-3

Abstract: These predictors include but are certainly not limited to genetic variations, clinical factors, and demographicHowever, no clinical application is currently available.

Keywords： rheumatoid arthritis     gene     clinical markers     therapy    

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Anatomy and embryology of umbilicus in newborns: a review and clinical correlations

Abdelmonem A. Hegazy

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 271-277 doi: 10.1007/s11684-016-0457-8

Abstract: This article aimed to address the basic knowledge of the umbilicus in relation to clinical disordersThus, the umbilicus is prone to various clinical disorders.

Keywords： anatomy     embryology     newborns     umbilicus    

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Clinical factors associated with composition of lung microbiota and important taxa predicting clinical

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 389-402 doi: 10.1007/s11684-021-0856-3

Abstract: The primary outcome was clinical improvements defined as a decrease of 2 categories and above on a 7-α-diversity and the abundance of the families Prevotellaceae and Actinomycetaceae were associated with clinicalThe families Prevotellaceae and Actinomycetaceae on admission predicted clinical improvements.

Keywords： severe community-acquired pneumonia     lung microbiota     clinical improvements     7-category ordinal scale    

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Scientific computation of big data in real-world clinical research

Guozheng Li,Xuewen Zuo,Baoyan Liu

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 310-315 doi: 10.1007/s11684-014-0358-7

Abstract: integration of science, technology, and medicine under the guidance of the paradigm of real-world, clinicalTCM clinical diagnosis, treatment, and knowledge were traditionally limited to literature and sensationmethods are applied in the modeling and analysis of the various complex relationships in individualized clinicalThus, these methods strongly support the real-world clinical research paradigm of TCM.

Keywords： big data     real world     clinical research     Chinese medicine     medical computing    

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MicroRNAs and lung cancers: from pathogenesis to clinical implications

Ji Qi, David Mu

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 134-155 doi: 10.1007/s11684-012-0188-4

Abstract: Better understanding of the disease is warranted for improvement in clinical management.

Keywords： lung biology     lung cancer     microRNA    

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Title Author Date Type Operation

xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research and a new co-clinicalmodel for treatment optimization

Shuyang Sun,Zhiyuan Zhang

Journal Article

A study on specialist or special disease clinics based on big data

Zhuyuan Fang,Xiaowei Fan,Gong Chen

Journal Article

The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant

Journal Article

Ontological reconstruction of the clinical terminology of traditional Chinese medicine

Li Ma,Baoyan Liu,Qi Xie,Shusong Mao,Zhiwei Cui

Journal Article

Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment

Tianhua Xu, Zitong Sheng, Li Yao

Journal Article

Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

Journal Article

Design and Application of Clinical Big Data Management System for Oncology

Ma Lin, Bao Chenlu, Li Qing,Wu Jingyi, Pan Hong’an, Li Pengfei, Zhang Luxia, Zhan Qimin

Journal Article

Coronavirus disease 2019 (COVID-19): a clinical update

Min Zhou, Xinxin Zhang, Jieming Qu

Journal Article

Hypertension in patients with CKD in China: clinical characteristics and management

Guangyan Cai, Xiangmei Chen

Journal Article

Biological properties and clinical applications of berberine

Danyang Song, Jianyu Hao, Daiming Fan

Journal Article

Genetic and clinical markers for predicting treatment responsiveness in rheumatoid arthritis

Xin Wu, Xiaobao Sheng, Rong Sheng, Hongjuan Lu, Huji Xu

Journal Article

Anatomy and embryology of umbilicus in newborns: a review and clinical correlations

Abdelmonem A. Hegazy

Journal Article

Clinical factors associated with composition of lung microbiota and important taxa predicting clinical

Journal Article

Scientific computation of big data in real-world clinical research

Guozheng Li,Xuewen Zuo,Baoyan Liu

Journal Article

MicroRNAs and lung cancers: from pathogenesis to clinical implications

Ji Qi, David Mu

Journal Article