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Endoscopic resection of a huge Brunner's gland adenoma

ZHANG Binbin, REN Xu, TANG Xiufen, CHI Yuxin, SHI Xuesong

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 414-418 doi: 10.1007/s11684-008-0080-4

Abstract: Upper gastro-intestinal (GI) endoscopy revealed a large pedunculated tumour on the superior part of the

Keywords： superior     Histological examination     endoscopy     gastro-intestinal     gastrointestinal haemorrhage    

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ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis

Frontiers of Medicine   Pages 972-992 doi: 10.1007/s11684-023-0990-1

Abstract: Moreover, ADT-OH reduced intestinal inflammation by suppressing the nuclear factor kappa-B pathway.In vivo and in vitro results showed that ADT-OH decreased intestinal permeability by increasingIn addition, ADT-OH restored intestinal microbiota dysbiosis characterized by the significantly increased

Keywords： inflammatory bowel disease     ADT-OH     intestinal permeability     gut microbiota    

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Altered intestinal microbiota associated with colorectal cancer

Hong Zhang, Ying Chang, Qingqing Zheng, Rong Zhang, Cheng Hu, Weiping Jia

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 461-470 doi: 10.1007/s11684-019-0695-7

Abstract: The gut microbiota plays an important role in the development and progression of colorectal cancer (CRC). To learn more about the dysbiosis of carcinogenesis, we assessed alterations in gut microbiota in patients with CRC. A total of 23 subjects were enrolled in this study: 9 had CRC (CRC group) and 14 had normal colons (normal group). The microbiome of the mucosal–luminal interface of each subject was sampled and analyzed using 16S rRNA gene amplicon sequencing. We also used Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) to predict microbial functional profiles. The microbial composition of the mucosal lumen differed between the groups, and the presence of specific bacteria may serve as a potential biomarker for colorectal carcinogenesis. We identified a significant reduction in which is a butyrate-producing genera of bacteria, and a significant increase in in the gut microbiota of CRC patients. Different levels of gut microflora in healthy and CRC samples were identified. The observed abundance of bacterial species belonging to and may serve as a promising biomarker for the early detection of CRC.

Keywords： colorectal cancer (CRC)     gut microbiota     intestinal     Eubacterium     Devosia    

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Effect of intestinal ischemia/reperfusion injury on leptin and orexin-A levels

LIN Ji, YAN Guangtao, HAO Xiuhua, ZHANG Kai, GAO Xiaoning, LIAO Jie

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 87-92 doi: 10.1007/s11684-007-0017-3

Abstract: The aim of this paper is to explore the effect of intestinal ischemia/reperfusion (I/R) injury on leptinAn intestinal I/R injury model of rats was made; the rats were grouped according to the time of afterLeptin and orexin-A respond to intestinal I/R injury in a time-dependent manner, with leptin responding

Keywords： significant difference     intestinal I/R     transcriptase-polymerase     metabolic     central secretory    

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A belated revelation: from gastroesophageal reflux derived asthma to laryngotracheal irritation even spasm

WANG Zhonggao

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 127-129 doi: 10.1007/s11684-008-0023-0

Abstract: Gradually a hypothesis of a gastro-oesophago-laryngo-tracheal reflux took shape.Our modest effort to

Keywords： laryngotracheal irritation/spasm     gastro-oesophago-laryngo-tracheal     sequence     fundaplication     encouraging    

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Structural shifts in the intestinal microbiota of rats treated with cyclosporine A after orthotropic

Junjun Jia, Xinyao Tian, Jianwen Jiang, Zhigang Ren, Haifeng Lu, Ning He, Haiyang Xie, Lin Zhou, Shusen Zheng

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 451-460 doi: 10.1007/s11684-018-0675-3

Abstract: Understanding the effect of immunosuppressive agents on intestinal microbiota is important to reduceinvestigated the relationship between the commonly used immunosuppressive agent cyclosporine A (CSA) and the intestinalThe intestinal microbiota was assayed by denaturing gradient gel electrophoresis profiles and by using

Keywords： microbial community     liver transplantation     immunosuppressive agents     cyclosporine A    

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Ca-Alginate-Based Janus Capsules with a Pumping Effect for Intestinal-Targeted Controlled Release Article

Shuang Wen, XiaoJie Ju, Wenying Liu, Yuqiong Liu, Xingqun Pu, Zhuang Liu, Wei Wang, Rui Xie, Yousef Faraj, Liangyin Chu

Engineering 2023, Volume 24, Issue 5,   Pages 114-125 doi: 10.1016/j.eng.2022.05.021

Abstract:

A novel intestinal-targeted θ-shaped capsule with a pumping effect for the controlled releaseshell offers improved protection for the encapsulated drug in the stomach environment and excellent intestinal-targetedprovide a potential and novel model for developing responsive pumping controlled-release systems and intestinal-targeted

Keywords： Capsules     Ca-alginate     Intestinal-targeted delivery     Pumping effects     Controlled release    

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Antibiotics-mediated intestinal microbiome perturbation aggravates tacrolimus-induced glucose disorders

Yuqiu Han, Xiangyang Jiang, Qi Ling, Li Wu, Pin Wu, Ruiqi Tang, Xiaowei Xu, Meifang Yang, Lijiang Zhang, Weiwei Zhu, Baohong Wang, Lanjuan Li

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 471-481 doi: 10.1007/s11684-019-0686-8

Abstract: However, the former increases the risk of new-onset diabetes, whereas the latter impacts intestinal microbiota

Keywords： antibiotics     tacrolimus     glucose disorders     microbiome    

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compound Sophorae Flavescentis Jiechangrong capsule on expression of NF-κB p65 and STAT6 in the intestinal

Heng FAN MD, Jia ZHAO MM, Lin SHEN BM, Qing TANG MD, Zhexin SHOU MM, Li LIANG BM, Yi LIAO BM, Xiaoyan CHEN BM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 480-484 doi: 10.1007/s11684-009-0083-9

Abstract: -κB p65 (NF-κB p65) and signal transducer and activator of transcription 6 (STAT6) in the intestinalwas concluded that CSFJC can inhibit the activation and expression of NF-κB p65 and STAT6 in the intestinal

Keywords： colitis     ulcerative     compound Sophorae Flavescentis Jiechangrong capsule     nuclear factor-κ     B p65 (NF-κ     B p65)     signal transducer and activator of transcription 6 (STAT6)    

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Clinical Significance of the Correlation between Changes in the Major Intestinal Bacteria Species and Article

Lingling Tang, Silan Gu, Yiwen Gong, Bo Li, Haifeng Lu, Qiang Li, Ruhong Zhang, Xiang Gao, Zhengjie Wu, Jiaying Zhang, Yuanyuan Zhang, Lanjuan Li

Engineering 2020, Volume 6, Issue 10,   Pages 1178-1184 doi: 10.1016/j.eng.2020.05.013

Abstract: Our previous studies found that H7N9 patients had intestinal dysbiosis.The objective of this study was to investigate changes in the abundance of ten predominant intestinal

Keywords： Intestinal microbiota     COVID-19     SARS-CoV-2    

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Effect of salvia miltiorrhiza pretreatment on the CCK and VIP expression in hepatic ischemia-reperfusion-induced digestive tract congestion

Zhi-Yong ZHANG, Xiao-Ping CHEN, Qi-Ping LU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 317-322 doi: 10.1007/s11684-010-0035-4

Abstract: periods 45 min following hepatic ischemia on the expression of cholecystokinin (CCK) and vasoactive intestinal

Keywords： hepatic ischemia-reperfusion     digestive tract congestion     cholecystokinin     vasoactive intestinal peptide    

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Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Engineering doi: 10.1016/j.eng.2023.06.007

Abstract: Intestinal homeostasis is maintained by specialized host cells and the gut microbiota.To explore the effects and mechanism of intestinal Axin1 in regulating intestinal homeostasis and colitis, we generated new mouse models with Axin1 conditional knockout in intestinal epithelial cellIn conclusion, we found that the loss of intestinal Axin1 protects against colitis, likely driven byOur study demonstrates a novel role of Axin1 in mediating intestinal homeostasis and the microbiota.

Keywords： Axin1     Bacteria     Microbiome inflammation     Inflammatory bowel disease     Immunity     Microbiome     Paneth cells     Akkermansia muciniphila     Wnt    

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The Biofunctions of Phytochemicals and Their Applications in Farm Animals: The Nrf2/Keap1 System as a Target

Si Qin, De-Xing Hou

Engineering 2017, Volume 3, Issue 5,   Pages 738-752 doi: 10.1016/J.ENG.2017.03.011

Abstract: We then summarize the effects of phytochemicals on the growth performance, meat quality, and intestinal

Keywords： Phytochemical     Biofunction     Nrf 2/Keap1 system     Growth performance     Meat quality     Intestinal microbiota    

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A Screening Model for Probiotics Against Specific Metabolic Diseases Based on Caco-2 Monolayer Membrane Article

Yang Liu, Jiang Peng, Shiya Zhu, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Wei Chen, Qixiao Zhai

Engineering 2023, Volume 25, Issue 6,   Pages 222-233 doi: 10.1016/j.eng.2022.02.014

Abstract: Recent studies have revealed the potency of probiotics in alleviating metabolic diseases associated with intestinalnecrosis factor (TNF-α) or alcohol was used to evaluate the effect of 139 Lactobacillus strains on intestinal

Keywords： Lactobacillus     Intestinal barrier     Caco-2 cells     Screening model     Metabolic diseases    

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Reconstruction and Dynamics of the Human Intestinal Microbiome Observed In Situ Article

Xiaolin Liu, Min Dai, Yue Ma, Na Zhao, Ziyu Wang, Ying Yu, Yakun Xu, Huijie Zhang, Liyuan Xiang, He Tian, Guanghou Shui, Faming Zhang, Jun Wang

Engineering 2022, Volume 15, Issue 8,   Pages 89-101 doi: 10.1016/j.eng.2021.03.015

Abstract:

The human gut microbiome has primarily been studied through the use of fecal samples, a practice that has generated vital knowledge on the composition and functional capacities of gastrointestinal microbial communities. However, this reliance on fecal materials limits the investigation of microbial dynamics in other locations along the gastrointestinal tract (in situ), and the infrequent availability of fecal samples prevents analysis at finer temporal scales (e.g., hours). In our study, we utilized colonic transendoscopic enteral tubing, a technology originally developed for fecal microbiota transplantation, to sample the ileocecal microbiome twice daily; metagenomic and metatranscriptomic analyses were then conducted on these samples. A total of 43 ileocecal and 28 urine and fecal samples were collected from five healthy volunteers. The ileocecal and fecal microbiomes, as profiled in the five volunteers, were found to be similar in metagenomic profiling, yet their active genes (metatranscriptome) were found to be highly distinct. Both microbiomes were perturbed after laxative exposure; over time, they exhibited reduced dissimilarity to their pre-treatment state, thereby demonstrating resilience as an innate property of the gut microbiome, although they did not fully recover within our observation time window. Sampling of the ileocecal microbiome during the day and at night revealed the existence of diurnal rhythms in a series of bacterial species and functional pathways, particularly those related to short-chain fatty acid production, such as Propionibacterium acnes and coenzyme A biosynthesis II. Autocorrelation analysis and fluctuations decomposition further indicated the significant periodicity of the diurnal oscillations. Metabolomic profiling in the fecal and urine samples mirrored the perturbance and recovery in the gut microbiome, indicating the crucial contribution of the gut microbiome to many key metabolites involved in host health. This study provides novel insights into the human gut microbiome and its inner resilience and diurnal rhythms, as well as the potential consequences of these to the host.

Keywords： Diurnal rhythm     Reconstruction     Metagenome     Metatranscriptome     Metabolome     Transendoscopic enteral tubing    

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Title Author Date Type Operation

Endoscopic resection of a huge Brunner's gland adenoma

ZHANG Binbin, REN Xu, TANG Xiufen, CHI Yuxin, SHI Xuesong

Journal Article

ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis

Journal Article

Altered intestinal microbiota associated with colorectal cancer

Hong Zhang, Ying Chang, Qingqing Zheng, Rong Zhang, Cheng Hu, Weiping Jia

Journal Article

Effect of intestinal ischemia/reperfusion injury on leptin and orexin-A levels

LIN Ji, YAN Guangtao, HAO Xiuhua, ZHANG Kai, GAO Xiaoning, LIAO Jie

Journal Article

A belated revelation: from gastroesophageal reflux derived asthma to laryngotracheal irritation even spasm

WANG Zhonggao

Journal Article

Structural shifts in the intestinal microbiota of rats treated with cyclosporine A after orthotropic

Junjun Jia, Xinyao Tian, Jianwen Jiang, Zhigang Ren, Haifeng Lu, Ning He, Haiyang Xie, Lin Zhou, Shusen Zheng

Journal Article

Ca-Alginate-Based Janus Capsules with a Pumping Effect for Intestinal-Targeted Controlled Release

Shuang Wen, XiaoJie Ju, Wenying Liu, Yuqiong Liu, Xingqun Pu, Zhuang Liu, Wei Wang, Rui Xie, Yousef Faraj, Liangyin Chu

Journal Article

Antibiotics-mediated intestinal microbiome perturbation aggravates tacrolimus-induced glucose disorders

Yuqiu Han, Xiangyang Jiang, Qi Ling, Li Wu, Pin Wu, Ruiqi Tang, Xiaowei Xu, Meifang Yang, Lijiang Zhang, Weiwei Zhu, Baohong Wang, Lanjuan Li

Journal Article

compound Sophorae Flavescentis Jiechangrong capsule on expression of NF-κB p65 and STAT6 in the intestinal

Heng FAN MD, Jia ZHAO MM, Lin SHEN BM, Qing TANG MD, Zhexin SHOU MM, Li LIANG BM, Yi LIAO BM, Xiaoyan CHEN BM,

Journal Article

Clinical Significance of the Correlation between Changes in the Major Intestinal Bacteria Species and

Lingling Tang, Silan Gu, Yiwen Gong, Bo Li, Haifeng Lu, Qiang Li, Ruhong Zhang, Xiang Gao, Zhengjie Wu, Jiaying Zhang, Yuanyuan Zhang, Lanjuan Li

Journal Article

Effect of salvia miltiorrhiza pretreatment on the CCK and VIP expression in hepatic ischemia-reperfusion-induced digestive tract congestion

Zhi-Yong ZHANG, Xiao-Ping CHEN, Qi-Ping LU

Journal Article

Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Journal Article

The Biofunctions of Phytochemicals and Their Applications in Farm Animals: The Nrf2/Keap1 System as a Target

Si Qin, De-Xing Hou

Journal Article

A Screening Model for Probiotics Against Specific Metabolic Diseases Based on Caco-2 Monolayer Membrane

Yang Liu, Jiang Peng, Shiya Zhu, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Wei Chen, Qixiao Zhai

Journal Article

Reconstruction and Dynamics of the Human Intestinal Microbiome Observed In Situ

Xiaolin Liu, Min Dai, Yue Ma, Na Zhao, Ziyu Wang, Ying Yu, Yakun Xu, Huijie Zhang, Liyuan Xiang, He Tian, Guanghou Shui, Faming Zhang, Jun Wang

Journal Article