2019-02-28 , Volume 5 Issue 1

Cover illustration

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    Artemisinin and its derivatives represent the most important and influential class of drugs in the fight against malaria. In this issue, Tu and her colleagues discussed the process of discovery of artemisinin, the potential mechanism of action, and future application to other important diseases. The cover shows the Artemisia annua L. (Chinese name: Huanghuahao), from which the artemisinin was derived. The first recorded usage of Artemisia plants as a specific remedy for malarial symptoms was in Ge Hong’s Zhouhou Beiji Fang (Handbook of Prescriptions for Emergency) dating back to the Eastern Jin Dynasty (317–420 AD), which is also shown in the cover.

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    Editorial
  • Editorial
    The Quest for the Modernization and Internationalization of Traditional Chinese Medicine
    Boli Zhang , Shengli Yang , De-an Guo

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Editorial
    Cell Therapy: A New Era of Disease Intervention
    Ling Lu , Zhigang Tian , Xuehao Wang

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Topic Insights
  • Topic Insights
    Cell Therapy: Pharmacological Intervention Enters a Third Era
    Wei He

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Engineering Achievements
  • Engineering Achievements
    The Hong Kong–Zhuhai–Macao Bridge
    Yonglin Zhu , Ming Lin , Fanchao Meng , Xiaodong Liu , Wei Lin

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Engineering Achievements
    State-of-the-Art Technology in the Construction of Sea-Crossing Fixed Links with a Bridge, Island, and Tunnel Combination
    Yaojun Ge , Yong Yuan

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Research
  • Research Traditional Chinese Medicine—Perspective
    The Globalization of Traditional Medicines: Perspectives Related to the European Union Regulatory Environment
    Werner Knoess , Jacqueline Wiesner

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Research Traditional Chinese Medicine—Review
    Artemisinin, the Magic Drug Discovered from Traditional Chinese Medicine
    Jigang Wang , Chengchao Xu , Yin Kwan Wong , Yujie Li , Fulong Liao , Tingliang Jiang , Youyou Tu

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Research Traditional Chinese Medicine—Review
    Enhancing Clinical Efficacy through the Gut Microbiota: A New Field of Traditional Chinese Medicine
    Yan-Meng Lu , Jiao-Jiao Xie , Cong-Gao Peng , Bao-Hong Wang , Kai-Cen Wang , Lan-Juan Li

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Research Traditional Chinese Medicine—Review
    Biotechnology Applications of Plant Callus Cultures
    Thomas Efferth

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Research Traditional Chinese Medicine—Review
    Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the Efficacy of Traditional Chinese Medicine
    Ai-Hua Zhang , Hui Sun , Guang-Li Yan , Ying Han , Qi-Qi Zhao , Xi-Jun Wang

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Research Traditional Chinese Medicine—Review
    Andrographolide Loaded in Micro- and Nano-Formulations: Improved Bioavailability, Target-Tissue Distribution, and Efficacy of the “King of Bitters”
    Marta Casamonti , Laura Risaliti , Giulia Vanti , Veri Piazzini , Maria Camilla Bergonzi , Anna Rita Bilia

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Research Traditional Chinese Medicine—Review
    Safety Research in Traditional Chinese Medicine: Methods, Applications, and Outlook
    Yue Gao , Aihua Liang , Xiaohui Fan , Limin Hu , Feiran Hao , Yubo Li

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Research Traditional Chinese Medicine—Review
    Deeper Chemical Perceptions for Better Traditional Chinese Medicine Standards
    Jin-Jun Hou , Jian-Qing Zhang , Chang-Liang Yao , Rudolf Bauer , Ikhlas A. Khan , Wan-Ying Wu , De-an Guo

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Research Immunology—Review
    Immune Regulatory Cell Biology and Clinical Applications to Prevent or Treat Acute Graft-Versus-Host Disease
    Bruce R. Blazar

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Research Immunology—Review
    Natural Killer Cell-Based Immunotherapy for Cancer: Advances and Prospects
    Yuan Hu , Zhigang Tian , Cai Zhang

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Review Immunology—Review
    FOXP3 and Its Cofactors as Targets of Immunotherapies
    Yasuhiro Nagai , Lian Lam , Mark I. Greene , Hongtao Zhang

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Research Immunology—Review
    Quality Control and Nonclinical Research on CAR-T Cell Products: General Principles and Key Issues
    Yonghong Li , Yan Huo , Lei Yu , Junzhi Wang

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Research Immunology—Review
    Regulatory T Cells and Their Clinical Applications in Antitumor Immunotherapy
    Feng Xie , Rui Liang , Dan Li , Bin Li

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Research Immunology—Review
    Engineered T Cell Therapies from a Drug Development Viewpoint
    Fang Chen , Joseph A. Fraietta , Carl H. June , Zhongwei Xu , J. Joseph Melenhorst , Simon F. Lacey

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Research Immunology—Article
    Donor-Derived CD19-Targeted T Cell Infusion Eliminates B Cell Acute Lymphoblastic Leukemia Minimal Residual Disease with No Response to Donor Lymphocytes after Allogeneic Hematopoietic Stem Cell Transplantation
    Yifei Cheng , Yuhong Chen , Chenhua Yan , Yu Wang , Xiangyu Zhao , Yao Chen , Wei Han , Lanping Xu , Xiaohui Zhang , Kaiyan Liu , Shasha Wang , Lungji Chang , Lei Xiao , Xiaojun Huang

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Research Artificial Intelligence—Article
    Wasserstein GAN-Based Small-Sample Augmentation for New-Generation Artificial Intelligence: A Case Study of Cancer-Staging Data in Biology
    Yufei Liu , Yuan Zhou , Xin Liu , Fang Dong , Chang Wang , Zihong Wang

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Research Robotics—Article
    Enhanced Autonomous Exploration and Mapping of an Unknown Environment with the Fusion of Dual RGB-D Sensors
    Ningbo Yu , Shirong Wang

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Research Synthetic Biology—Article
    An Additive Manufacturing Approach that Enables the Field Deployment of Synthetic Biosensors
    Daniel Wolozny , John R. Lake , Paul G. Movizzo , Zhicheng Long , Warren C. Ruder

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

  • Corrigendum
    Corrigendum to ‘‘A Comparison of SWAT Model Calibration Techniques for Hydrological Modeling in the Ganga River Watershed” [Engineering 4 (2018) 643–652]
    Nikita Shivhare , Prabhat Kumar Singh Dikshit , Shyam Bihari

    Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron−hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider−hadron−hadron (FCC-hh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, and particle classification. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.