检索范围：
排序： 展示方式：
杨天社,陈忠彬
《中国工程科学》 2002年 第4卷 第4期 页码 79-82
顾学红,徐南平
《中国工程科学》 2014年 第16卷 第12期 页码 52-58
郑长建,郭景学,姜晓燕,王文昌
《中国工程科学》 2012年 第14卷 第4期 页码 58-61
邱菀华,谷晓燕
《中国工程科学》 2011年 第13卷 第8期 页码 73-79
介绍了管理学、决策论和信息学的一个新交叉研究领域——工程管理熵学，从它诞生的必要性、科学性出发，进而阐述其理论基础、方法与模型，特别介绍了复熵决策法、群决策熵模型和多因素耦合决策熵方法，最后给出的工程管理应用案例表明，所提出的熵模型能够有效地解决实际工程管理中的决策难题。
李立希,李铧汶,杨春燕
《中国工程科学》 2004年 第6卷 第7期 页码 53-59
可拓学在数据挖掘中的应用是多方面的，其特点是挖掘“不行变行”的规律。可拓方法丰富了数据挖掘的内容，为多值型关联规则的建立提供了新的工具。
张福学
《中国工程科学》 2002年 第4卷 第8期 页码 50-53
根据自然对流气体具有摆的特性，从而提出气体摆新概念。分析了密闭腔中自然对流气体的浮升力，给出浮升力与温度变化的关系式。试验结果表明，与固体摆、液体摆一样，利用气体摆原理亦能检测加速度和倾角。
代谢组扩展生物学的“旁中心法则”——对理解基因组学-糖组学-代谢组学-表观基因组学互作的意义
Albert Stuart Reece
《工程（英文）》 2023年 第26卷 第7期 页码 16-16 doi: 10.1016/j.eng.2022.07.011
The central dogma of biology holds that the transcription of DNA into RNA and the translation of RNA into proteins forms the primary axis of biological activity [1]. Following major advances in the description of the complex glycan and lipid chains that are added onto these basic building blocks, the glycome and lipidome have recently been added to this doctrine as an exciting new extension named the ‘‘paracentral dogma” [2]. However, it has been pointed out that biological systems can include many layers, which are described in modern omics technology platforms relating to both cell-intrinsic and cell-extrinsic layers of control, including metabolomic, microbiomic, immunological, epigenomic, epitranscriptomic, proteomic and phosphoproteomic layers [3].
It is well known that stem and progenitor cells have a metabolism that is based on glycolysis and glutaminolysis [4]. Although this provides less energy to the cell than oxidative phosphorylation, it suffices for these cells’ needs, since such cells are generally relatively quiescent and normally suppress energy-intensive processes such as genome duplication and transcription. Moreover, it has been shown that the high intracellular lactate levels involved in such states not only inhibits the key gatekeeper enzymes of oxidative phosphorylation (i.e., pyruvate dehydrogenase and carnitine palmitoyl acyltransferase) but also actually covalently modifies them by lactylation in order to maintain this inhibited metabolic–epigenomic state [5]. In addition, intermediate metabolism and nutrients are the source of the very extensive library of post-translational modifications to DNA, RNA, and proteins, as well as supplying cellular energy for many of the required reactions. Hence, the metabolic state locks in and reinforces the epigenomic state, and the metabolome and epigenome thereby play mutually reinforcing roles. This self-reinforcing coordination explains why it is so difficult to generate induced pluripotent cells and is a contributory explanation for why the described protocols typically have such low cellular yields.
These concepts become even more important when it is considered that cancer cells are de-differentiated, similarly rely on glycolysis and glutaminolysis, and are similarly metabolically–epigenomically–genomically synchronized. The disruption of this metabolic system is a key focus of mechanistic cancer research.
These important considerations imply that the descriptive and predictive power of the newly described ‘‘paracentral dogma” of biology may be usefully and meaningfully extended by including the metabolome, along with the genome, transcriptome, proteome, glycome, and lipidome, to describe cell-intrinsic regulation—not only in terms of another omics analytical layer but also as a fully predictive and interactive partner in the symphonic-like multilayer coordination that evidently comprises cellular regulatory layering.
未来工程中的声学超构材料 Perspective
鲁强兵, 李鑫, 张秀娟, 卢明辉, 陈延峰
《工程（英文）》 2022年 第17卷 第10期 页码 22-30 doi: 10.1016/j.eng.2022.04.020
高学杰, Filippo Giorgi
《工程（英文）》 2017年 第3卷 第5期 页码 766-772 doi: 10.1016/J.ENG.2017.05.019
标题 作者 时间 类型 操作
京公网安备 11010502051620号
