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Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets
Feng Wang,Chen Chen,Daowen Wang
Frontiers of Medicine 2014, Volume 8, Issue 4, Pages 404-418 doi: 10.1007/s11684-014-0379-2
Keywords: microRNA cardiovascular disease biomarkers therapeutic target
Brown and beige fat: the metabolic function, induction, and therapeutic potential
Shuwen Qian,Haiyan Huang,Qiqun Tang
Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 162-172 doi: 10.1007/s11684-015-0382-2
Keywords: brown adipocyte beige adipocyte metabolism obesity
Molecular mechanisms and therapeutic strategies of vulnerable atherosclerotic plaques
Wen-Qiang CHEN MD, Yun ZHANG MD, PhD, FACC,
Frontiers of Medicine 2010, Volume 4, Issue 1, Pages 36-42 doi: 10.1007/s11684-010-0020-y
Keywords: vulnerable plaque animal models mechani-sm detection treatment
Guangbiao Zhou, Saijuan Chen, Zhu Chen
Frontiers of Medicine 2020, Volume 14, Issue 2, Pages 117-125 doi: 10.1007/s11684-020-0773-x
Keywords: COVID-19 SARS-CoV-2 pathogenesis evidence-based medicine control and therapeutic strategies
Peter B. Alexander,Xiao-Fan Wang
Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 134-138 doi: 10.1007/s11684-015-0396-9
Keywords: targeted therapy drug resistance receptor tyrosine kinases cancer
Amma Owusu-Ansah,Sung Hee Choi,Agne Petrosiute,John J. Letterio,Alex Yee-Chen Huang
Frontiers of Medicine 2015, Volume 9, Issue 1, Pages 46-56 doi: 10.1007/s11684-015-0375-1
Keywords: oxidative stress Nrf2 triterpenoids sickle cell disease vaso-occlusion CDDO-Me
Frontiers of Medicine doi: 10.1007/s11684-023-1050-6
Keywords: pancreatic cancer cancer screening single cell molecular alterations precancerous lesion therapy resistance
Base editors: development and applications in biomedicine
Frontiers of Medicine 2023, Volume 17, Issue 3, Pages 359-387 doi: 10.1007/s11684-023-1013-y
Keywords: base editing CBE ABE ADAR DdCBE disease model therapeutic application
AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches
Megan A. Hatlen, Lan Wang, Stephen D. Nimer
Frontiers of Medicine 2012, Volume 6, Issue 3, Pages 248-262 doi: 10.1007/s11684-012-0206-6
Keywords: AML1-ETO mouse model leukemia t(8 21) pathway hits mutation hematopoiesis Kasumi-1 CD34+
Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases
Chong Liu, Dingfeng Su
Frontiers of Medicine 2012, Volume 6, Issue 1, Pages 35-40 doi: 10.1007/s11684-012-0171-0
Inflammation is important in the pathogenesis and development of cardiovascular diseases. Recent studies show that vagus nerve stimulation inhibits pro-inflammatory cytokine production through “the cholinergic anti-inflammatory pathway,” more specifically via the α7 nicotinic acetylcholine receptor (α7nAChR). In the current study, the role of the cholinergic anti-inflammatory pathway during septic shock, hypertension, and myocardial infarction is reviewed, and its possible clinical implications in cardiovascular diseases are discussed.
Keywords: α7 nicotinic acetylcholine receptor cardiovascular diseases baroreflex sensitivity
Observation on therapeutic efficacy of ursodeoxycholic acid in Chinese patients with primary biliary
Jiangyi Zhu, Yongquan Shi, Xinmin Zhou, Zengshan Li, Xiaofeng Huang, Zheyi Han, Jianhong Wang, Ruian Wang, Jie Ding, Kaichun Wu, Ying Han, Daiming Fan
Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 255-263 doi: 10.1007/s11684-012-0227-1
Keywords: primary biliary cirrhosis ursodeoxycholic acid Chinese biochemical response therapeutic efficacy
Early diagnosis and therapeutic choice of
Jing LI, Ying FU, Ji-Yao WANG, Chuan-Tao TU, Xi-Zhong SHEN, Lei LI, Wei JIANG
Frontiers of Medicine 2010, Volume 4, Issue 3, Pages 308-316 doi: 10.1007/s11684-010-0103-9
Keywords:
liver abscess
Frontiers of Medicine 2022, Volume 16, Issue 5, Pages 723-735 doi: 10.1007/s11684-021-0905-y
Keywords: amyotrophic lateral sclerosis coronin-1a autophagy pathogenesis
Therapeutic application of hydrogen sulfide donors: the potential and challenges
Dan Wu,Qingxun Hu,Yizhun Zhu
Frontiers of Medicine 2016, Volume 10, Issue 1, Pages 18-27 doi: 10.1007/s11684-015-0427-6
Hydrogen sulfide (H2S), a colorless gas smelling of rotten egg, has long been considered a toxic gas and environment hazard. However, evidences show that H2S plays a great role in many physiological and pathological activities, and it exhibits different effects when applied at various doses. In this review, we summarize the chemistry and biomedical applications of H2S-releasing compounds, including inorganic salts, phosphorodithioate derivatives, derivatives of Allium sativum extracts, derivatives of thioaminoacids, and derivatives of anti-inflammatory drugs.
Keywords: hydrogen sulfide cardiovascular cancer hypertension
Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers
Ulrich L?CHELT, Ernst WAGNER
Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 3, Pages 275-286 doi: 10.1007/s11705-011-1203-z
Title Author Date Type Operation
Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets
Feng Wang,Chen Chen,Daowen Wang
Journal Article
Brown and beige fat: the metabolic function, induction, and therapeutic potential
Shuwen Qian,Haiyan Huang,Qiqun Tang
Journal Article
Molecular mechanisms and therapeutic strategies of vulnerable atherosclerotic plaques
Wen-Qiang CHEN MD, Yun ZHANG MD, PhD, FACC,
Journal Article
Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies
Guangbiao Zhou, Saijuan Chen, Zhu Chen
Journal Article
Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies
Peter B. Alexander,Xiao-Fan Wang
Journal Article
Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review
Amma Owusu-Ansah,Sung Hee Choi,Agne Petrosiute,John J. Letterio,Alex Yee-Chen Huang
Journal Article
Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic
Journal Article
AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches
Megan A. Hatlen, Lan Wang, Stephen D. Nimer
Journal Article
Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases
Chong Liu, Dingfeng Su
Journal Article
Observation on therapeutic efficacy of ursodeoxycholic acid in Chinese patients with primary biliary
Jiangyi Zhu, Yongquan Shi, Xinmin Zhou, Zengshan Li, Xiaofeng Huang, Zheyi Han, Jianhong Wang, Ruian Wang, Jie Ding, Kaichun Wu, Ying Han, Daiming Fan
Journal Article
Early diagnosis and therapeutic choice of
Jing LI, Ying FU, Ji-Yao WANG, Chuan-Tao TU, Xi-Zhong SHEN, Lei LI, Wei JIANG
Journal Article
Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic
Journal Article
Therapeutic application of hydrogen sulfide donors: the potential and challenges
Dan Wu,Qingxun Hu,Yizhun Zhu
Journal Article