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Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets

Feng Wang,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 404-418 doi: 10.1007/s11684-014-0379-2

Abstract: In the past several years, the aberrant expressions of miRNAs in the cardiovascular system have beenreported, and the crucial roles of some special miRNAs in heart development and pathophysiology of various cardiovascularThese discoveries not only reveal the functions of circulating miRNAs in cardiovascular system but alsoIn this review, we discuss the potential roles of circulating miRNAs in a variety of cardiovascular diseasesfrom biomarkers to therapeutic targets to clearly understand the roles of circulating miRNAs in cardiovascular

Keywords： microRNA     cardiovascular disease     biomarkers     therapeutic target    

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Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

Chong Liu, Dingfeng Su

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 35-40 doi: 10.1007/s11684-012-0171-0

Abstract:

Inflammation is important in the pathogenesis and development of cardiovascular diseases.shock, hypertension, and myocardial infarction is reviewed, and its possible clinical implications in cardiovascular

Keywords： α7 nicotinic acetylcholine receptor     cardiovascular diseases     baroreflex sensitivity    

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Multislice computed tomography angiography in the diagnosis of cardiovascular disease: 3D visualizations

Zhonghua Sun

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 254-270 doi: 10.1007/s11684-011-0153-7

Abstract: Multislice computed tomography (CT) has been widely used in clinical practice for the diagnosis of cardiovascularThe imaging diagnosis of cardiovascular disease is based on a combination of two-dimensional (2D) andarticle is to present an overview of the diagnostic performance of various 2D and 3D CT visualizations in cardiovascularefficiently using the multislice CT imaging modality for the diagnostic management of patients with cardiovascular

Keywords： cardiovascular disease     multislice computed tomography     three-dimensional reconstruction     diagnosis     visualization    

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Prevalence of cardiovascular diseases in China

Jun-Jie XIAO MD, Yi-Han CHEN MD, PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 16-20 doi: 10.1007/s11684-010-0007-8

Abstract: Cardiovascular diseases (CVD) cause one third of all deaths in China, and the number is anticipated to

Keywords： cardiovascular diseases     prevalence     China     risk factors     prevention    

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Potential functions of esophageal cancer-related gene-4 in the cardiovascular system

Rui Zhou, Yuanshu Liu, Wenjun Huang, Xitong Dang

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 639-645 doi: 10.1007/s11684-019-0701-0

Abstract: participating in the rhythm and rate control of the heart, and possibly gauging the responsiveness of the cardiovascular

Keywords： tumor suppressor gene     esophageal cancer-related gene-4     cardiovascular disease     hypoxia    

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IgG N-Glycosylation Cardiovascular Age Tracks Cardiovascular Risk Beyond Calendar Age Article

Zhiyuan Wu, Zheng Guo, Yulu Zheng, Yutao Wang, Haiping Zhang, Huiying Pan, Zhiwei Li, Lois Balmer, Xia Li, Lixin Tao, Xiuhua Guo, Wei Wang

Engineering 2023, Volume 26, Issue 7,   Pages 99-107 doi: 10.1016/j.eng.2022.12.004

Abstract: in subclinical atherosclerosis and metabolic disorders, both of which are important risk factors in cardiovascularHowever, the usable capacity of IgG N-glycosylation profiles for the risk stratification of cardiovascularThis study aimed to develop a cardiovascular aging index for tracking cardiovascular risk using IgG cardiovascular risk.The area under curve (AUC) values of discriminating high cardiovascular risk and events were 0.73 and

Keywords： IgG N-glycosylation cardiovascular age     Cardiovascular aging     Immunoglobulin G     Glycosylation     Inflammation    

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Therapeutic application of hydrogen sulfide donors: the potential and challenges

Dan Wu,Qingxun Hu,Yizhun Zhu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 18-27 doi: 10.1007/s11684-015-0427-6

Abstract:

Hydrogen sulfide (H2S), a colorless gas smelling of rotten egg, has long been considered a toxic gas and environment hazard. However, evidences show that H2S plays a great role in many physiological and pathological activities, and it exhibits different effects when applied at various doses. In this review, we summarize the chemistry and biomedical applications of H2S-releasing compounds, including inorganic salts, phosphorodithioate derivatives, derivatives of Allium sativum extracts, derivatives of thioaminoacids, and derivatives of anti-inflammatory drugs.

Keywords： hydrogen sulfide     cardiovascular     cancer     hypertension    

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Design, Characterization, and 3D Printing of Cardiovascular Stents with Zero Poisson’s Ratio in Longitudinal Article

Chengjin Wang, Lei Zhang, Yongcong Fang, Wei Sun

Engineering 2021, Volume 7, Issue 7,   Pages 979-990 doi: 10.1016/j.eng.2020.02.013

Abstract: Inherent drawbacks associated with drug-eluting stents have prompted the development of bioresorbable cardiovascular

Keywords： Additive manufacturing     3D printing     Screw extrusion     Cardiovascular stent     Zero Poisson’s ratio    

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Research and Progress of Implantable Cardiovascular Materials and Devices

Yunbing Wang

Engineering 2021, Volume 7, Issue 12,   Pages 1707-1709 doi: 10.1016/j.eng.2021.08.011

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Poor adherence to P2Y12 antagonists increased cardiovascular risks in Chinese PCI-treated patients

Yang Sun,Chenze Li,Lina Zhang,Dong Hu,Xudong Zhang,Ting Yu,Min Tao,Dao Wen Wang,Xiaoqing Shen

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 53-61 doi: 10.1007/s11684-017-0502-2

Abstract:

Low adherence to secondary prevention medications (ATM) of patients after acute coronary syndrome (ACS) is associated with poor clinical outcomes. However, literature provides limited data on assessment of ATM and risks associated with poor in Chinese patients with ACS. In the current work, ATM was assessed in consecutively recruited patients with ACS in Tongji Hospital from November 5, 2013 to December 31, 2014. A total of 2126 patients were classified under low adherence (proportion of days covered (PDC)<50%) and high adherence (PDC>50%) groups based on their performance after discharge. All patients were followed up at the 1st, 6th, and 12th month of discharge while recording ATM and major adverse cardiac events (MACE). Bivariate logistic regression was used to identify the factors associated with ATM. Cox regression was used to analyze the association between ATM and MACE within one year after discharge. Results showed that coronary artery bypass grafting (CABG) alone had significantly lower proportion of high adherence to P2Y12 antagonists (83.0% vs. 90.7%, P<0.01) than patients treated with percutaneous coronary intervention (PCI) only. Moreover, in patients undergoing PCI, high adherence to P2Y12 antagonists decreased the risk of MACE (hazard ratio=0.172, 95% confidence interval: 0.039–0.763; P=0.021). In conclusion, PCI-treated patients are more prone to remaining adherent to medications than CABG-treated patients. High adherence to P2Y12 antagonists was associated with lower risk of MACE.

Keywords： acute coronary syndromes     adherence to secondary prevention medications     clinical outcome    

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Association of metabolic syndrome with arterial compliance in children and adolescents

ZHANG Li, MI Jie, LI Ming, JIANG Benyu

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 68-73 doi: 10.1007/s11684-007-0014-6

Abstract: that arterial compliance assessment in children and adolescents was important for early prevention of cardiovascular

Keywords： compliance assessment     correlation analysis     cardiovascular     clustering     HOMA-IR    

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Physiological functions and clinical implications of the N-end rule pathway

Yujiao Liu,Chao Liu,Wen Dong,Wei Li

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 258-270 doi: 10.1007/s11684-016-0458-7

Abstract: differentiation, chromosomal segregation, genome stability, apoptosis, mitochondrial quality control, cardiovascular

Keywords： N-end rule pathway     Ate1     cardiovascular development     neurogenesis     spermatogenesis     neurodegenerative disorders    

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Bioactive Components of Chinese Herbal Medicines in the Treatment of Glucose and Lipid Metabolism Disorders: Evidence and Potential Mechanisms Review

Ying Zhang, Jiaming Ju, Lei Jiao, Baofeng Yang

Engineering 2023, Volume 29, Issue 10,   Pages 73-82 doi: 10.1016/j.eng.2023.03.004

Abstract: cholesterol and glucose homeostasis play crucial roles in the development of various diseases such as cardiovascularand blood glucose of patients is the predominant strategy for improving the symptoms of patients with cardiovascularMoreover, CHM has been widely used in China and other countries for the treatment of cardiovascular and

Keywords： Chinese herbal medicines     Hyperlipidemia     Hyperglycemia     Cardiovascular and cerebrovascular diseases    

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A Study on the Prevention and Control of Major Chronic Non-communicable Diseases Abroad

Zhang Zhuqin and Liu Depei

Strategic Study of CAE 2017, Volume 19, Issue 2,   Pages 112-116 doi: 10.15302/J-SSCAE-2017.02.019

Abstract:

Major chronic non-communicable diseases, including cardiovascular and

Keywords： chronic non-communicable diseases     cardiovascular and cerebrovascular diseases     cancer     respiratory diseases    

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Measurement of the normal fetal cardiovascular diameters by echocardiography during the second trimester

Ji Xueqin,Ding Lili,Suo Yaoyu,Shi Ruixian, Liu Yanxiang,Chen Yaoping

Strategic Study of CAE 2015, Volume 17, Issue 6,   Pages 77-81

Abstract:

To determine the normal range of the inner diameters of the anatomical structures in the fetal cardiovascularIn Ningxia, determining the normal range of fetal cardiovascular diameters during the second trimesterallows the evaluation of fetal cardiovascular system development and provides an important basis for

Keywords： fetal heart     ultrasound     normal range    

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Title Author Date Type Operation

Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets

Feng Wang,Chen Chen,Daowen Wang

Journal Article

Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

Chong Liu, Dingfeng Su

Journal Article

Multislice computed tomography angiography in the diagnosis of cardiovascular disease: 3D visualizations

Zhonghua Sun

Journal Article

Prevalence of cardiovascular diseases in China

Jun-Jie XIAO MD, Yi-Han CHEN MD, PhD,

Journal Article

Potential functions of esophageal cancer-related gene-4 in the cardiovascular system

Rui Zhou, Yuanshu Liu, Wenjun Huang, Xitong Dang

Journal Article

IgG N-Glycosylation Cardiovascular Age Tracks Cardiovascular Risk Beyond Calendar Age

Zhiyuan Wu, Zheng Guo, Yulu Zheng, Yutao Wang, Haiping Zhang, Huiying Pan, Zhiwei Li, Lois Balmer, Xia Li, Lixin Tao, Xiuhua Guo, Wei Wang

Journal Article

Therapeutic application of hydrogen sulfide donors: the potential and challenges

Dan Wu,Qingxun Hu,Yizhun Zhu

Journal Article

Design, Characterization, and 3D Printing of Cardiovascular Stents with Zero Poisson’s Ratio in Longitudinal

Chengjin Wang, Lei Zhang, Yongcong Fang, Wei Sun

Journal Article

Research and Progress of Implantable Cardiovascular Materials and Devices

Yunbing Wang

Journal Article

Poor adherence to P2Y12 antagonists increased cardiovascular risks in Chinese PCI-treated patients

Yang Sun,Chenze Li,Lina Zhang,Dong Hu,Xudong Zhang,Ting Yu,Min Tao,Dao Wen Wang,Xiaoqing Shen

Journal Article

Association of metabolic syndrome with arterial compliance in children and adolescents

ZHANG Li, MI Jie, LI Ming, JIANG Benyu

Journal Article

Physiological functions and clinical implications of the N-end rule pathway

Yujiao Liu,Chao Liu,Wen Dong,Wei Li

Journal Article

Bioactive Components of Chinese Herbal Medicines in the Treatment of Glucose and Lipid Metabolism Disorders: Evidence and Potential Mechanisms

Ying Zhang, Jiaming Ju, Lei Jiao, Baofeng Yang

Journal Article

A Study on the Prevention and Control of Major Chronic Non-communicable Diseases Abroad

Zhang Zhuqin and Liu Depei

Journal Article

Measurement of the normal fetal cardiovascular diameters by echocardiography during the second trimester

Ji Xueqin,Ding Lili,Suo Yaoyu,Shi Ruixian, Liu Yanxiang,Chen Yaoping

Journal Article