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Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 2,   Pages 225-232 doi: 10.1007/s11705-014-1429-7

Abstract: Here we review several common semi-solid polymers currently used in the controlled release formulationsThese polymers are selected based on their importance and broad scope of application in FDA-approved drugGlyceride-based polymers used in self-emulsifying drug delivery systems (SEDDS) will also be discussed

Keywords： controlled release     drug delivery     semi-solids     polymer     excipient    

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Controlled drug release of 5-amino salicylic acid by poly(2-hydroxyethylmethacrylate) grafted agar

G. Usha RANI,Kartick Prasad DEY,Srijita BHARTI,Sumit MISHRA

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 465-470 doi: 10.1007/s11705-014-1452-8

Abstract: drug release studies were performed at pH values of 2 and 7 in order to investigate the possibility ofpH triggered release for colon targeted drug delivery.(the time taken for release of 50% of the enclosed drug) value was studied and the results indicate thatit may be possible to develop a programmable drug release matrix based on grafted polysaccharide.Ag-g-P(HEMA) appears to be a useful matrix for controlled release.

Keywords： agar     controlled drug release     5-Amino salicylic acid     poly(2-hydroxyethylmethacrylate) grafted agar    

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Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 116-122 doi: 10.1007/s11705-013-1310-0

Abstract: acid was incorporated in the various Psy- -PMA samples and tablets were prepared to study the in vitro drugrelease in acidic (pH= 4), neutral (pH= 7), and basic (pH= 9) media.In addition, the biodegradable Psy- -PMA had the highest drug release in the acidic medium.This may be attributed to Fickian diffusion since the drug and the medium in which it was released have

Keywords： psyllium     acetyl salicylic acid     in-vitro drug release     swelling     biodegradation    

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Nanostructured hollow spheres of hydroxyapatite: preparation and potential application in drug delivery

Xiaojing ZHANG, Weixin ZHANG, Zeheng YANG, Zhao ZHANG

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 3,   Pages 246-252 doi: 10.1007/s11705-012-1299-9

Abstract: The properties of the different kinds of spheres as drug delivery carriers were evaluated.Ibuprofen (IBU) was chosen as the model drug to load into the HA samples.The nanostructured HA samples showed a slow and sustained release of IBU.The HA hollow spheres exhibited a higher drug loading capacity and more favorable release propertiesthan the HA solid spheres and thus are very promising for controlled drug release applications.

Keywords： hydroxyapatite     hollow spheres     synthesis     drug release    

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Design of nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic

Vaibhav Mundra, Ram I. Mahato

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 387-404 doi: 10.1007/s11705-014-1457-3

Abstract: Viruses exploit intracellular cues to release the genome to cytosol.

Keywords： nanocarrier     cellular uptake     endosomal release     nucleic acid drug    

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Synthesis and characterization of biocompatible polyurethanes for controlled release of hydrophobic and

Juichen YANG,Hong CHEN,Yuan YUAN,Debanjan SARKAR,Jie ZHENG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 498-510 doi: 10.1007/s11705-014-1451-9

Abstract: , and degradability of polyurethanes, the size and hydrophobicity of drugs, and drug-polymer interactionsDifferent drug-polyurethane combinations modulated the distribution and location of the drugs in polymermatrix, thus inducing different drug release mechanisms.highlight an important role of segmental structure of the polyurethane as an engineering tool to control drugrelease.

Keywords： phase structure     degradation     polyurethanes     controlled release     drug delivery    

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A novel cataplasma matrix of traditional Chinese medicine

Jing TIAN, Xiaolei ZHANG, Xueqin ZHOU,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 91-95 doi: 10.1007/s11705-009-0304-4

Abstract: Furthermore, the drug-compatibilities of the matrix were investigated with baicalin, berberine and curcuminThe drug contents could reach 4.12% , 2.42% and 3.75%, while the release rate were measured as, 361.79These results indicated that the obtained matrix had good drug-compatibility and drug-release properties

Keywords： drug-release     applicable     berberine     curcumin     different    

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Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 490-495 doi: 10.1007/s11684-018-0647-7

Abstract: case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistantWhile most cancer therapies are given in combinations that are designed to avoid drug resistance, wetherapeutic approaches that take advantage of the changes in cancer cells that arise upon development of drugThis approach is based on notion that drug resistance comes at a fitness cost to the cancer cell thatWe discuss the development of sequential drug therapies in which the first therapy is not given with

Keywords： cancer     drug resistance     genetic screens     senescence     targeted therapy    

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Protein microspheres for pulmonary drug delivery

Yongda SUN,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 82-86 doi: 10.1007/s11705-009-0307-1

Abstract: supercritical fluid (SCF) technique was developed for the preparation of microspheres for pulmonary drugleading to a dry fine powder with good particle size distribution and near ideal morphology for pulmonary drug

Keywords： advanced engineering     improved     pressure     aqueous     technique    

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Study on the NOx release rule along the boiler during pulverized coal combustion

JIN Jing, ZHANG Zhongxiao, LI Ruiyang

Frontiers in Energy 2007, Volume 1, Issue 1,   Pages 91-95 doi: 10.1007/s11708-007-0009-7

Abstract: Numerical simulation and experimental study on NO release along the boiler during pulverized coal combustionWith the increase of temperature the NO emission increased and the peak value of NO release moved forwardThe peak value of NO release moved backwards with the increase of coal rank.
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Capacity estimation and preliminary strategy for reducing the release of dioxins in China

YU Gang, ZHANG Qing, HUANG Jun, CAI Zhenxiao, SUI Qian

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 1,   Pages 13-17 doi: 10.1007/s11783-007-0002-8

Abstract: The strategy and action plan for reducing the release of dioxins in China are the most important componentssources for applying the best available technology/best environmental practice (BAT/BEP) to reduce the releaseHow about the capacity for reducing the dioxins release from the key sources?The list of key sources covering about half of the total dioxins release was determined considering fourcorresponding to the scenario that all key sources have been applied BAT/BEP to reduce the dioxins release

Keywords： GIS     difference     capacity     scenario     implementation    

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functional supramolecular nanoparticles based on pillar[5]arene for controlled generation, storage and release

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 3,   Pages 307-313 doi: 10.1007/s11705-022-2216-5

Abstract: The storage and controlled release of singlet oxygen (1O2) have attracted increasinghydroxyphenyl)porphyrin (TPP), that may provide the controlled generation, storage and releaseinto one functional system, which provides a new strategy for the controlled generation, storage and release

Keywords： storage and controlled release of singlet oxygen     supramolecular nanoparticles     noncovalent interactions    

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Phosphorus release potential and pollution characteristics of sediment in downstream Nansi Lake, China

Zhijian LI, Qinyan YUE, Baoyu GAO, Yanwen WANG, Qing LIU

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 2,   Pages 162-170 doi: 10.1007/s11783-011-0313-7

Abstract: to evaluate present and potential phosphorous pollution due to high sedimentary phosphorus load and releaseKinetics and isotherms of adsorption/release of sedimentary phosphorus were studied to determine equilibriumphosphate concentration (EPC ) and release potential.Kinetics of phosphorus adsorption on sediment and release from sediment were well described by both theimpermanent equilibrium with overlying water in status of phosphorus, the sediments can be likely to release

Keywords： Nansi Lake     sediment     phosphorus     release potential     equilibrium phosphate concentration    

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Prevalence of antifolate drug resistance markers in in China

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 83-92 doi: 10.1007/s11684-021-0894-x

Abstract: dhps) genes of Plasmodium vivax and antifolate resistance-associated genes were used for drugvivax parasites were different across China and molecular markers could be used to rapidly monitor drugResults provided evidence for updating national drug policy and treatment guidelines.

Keywords： drug resistance     antifolates     molecular markers     Plasmodium vivax     China    

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Clinical analysis of 275 cases of acute drug-induced liver disease

LI Lei, JIANG Wei, WANG Jiyao

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 58-61 doi: 10.1007/s11684-007-0012-8

Abstract: causative drugs, clinical manifestation and pathological characteristics of the patients with acute drug-inducedliver disease, from January 2000 to December 2005, 275 cases diagnosed as acute drug-induced liver diseasesEach was determined by drug history, clinical symptoms and signs, laboratory tests and therapeutic effectsThe proportion of acute drug-induced liver disease among all of the acute liver injuries was annuallyThe clinicians should pay attention to the prevention, diagnosis and therapy of drug-induced liver disease
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Title Author Date Type Operation

Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

Journal Article

Controlled drug release of 5-amino salicylic acid by poly(2-hydroxyethylmethacrylate) grafted agar

G. Usha RANI,Kartick Prasad DEY,Srijita BHARTI,Sumit MISHRA

Journal Article

Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

Journal Article

Nanostructured hollow spheres of hydroxyapatite: preparation and potential application in drug delivery

Xiaojing ZHANG, Weixin ZHANG, Zeheng YANG, Zhao ZHANG

Journal Article

Design of nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic

Vaibhav Mundra, Ram I. Mahato

Journal Article

Synthesis and characterization of biocompatible polyurethanes for controlled release of hydrophobic and

Juichen YANG,Hong CHEN,Yuan YUAN,Debanjan SARKAR,Jie ZHENG

Journal Article

A novel cataplasma matrix of traditional Chinese medicine

Jing TIAN, Xiaolei ZHANG, Xueqin ZHOU,

Journal Article

Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Journal Article

Protein microspheres for pulmonary drug delivery

Yongda SUN,

Journal Article

Study on the NOx release rule along the boiler during pulverized coal combustion

JIN Jing, ZHANG Zhongxiao, LI Ruiyang

Journal Article

Capacity estimation and preliminary strategy for reducing the release of dioxins in China

YU Gang, ZHANG Qing, HUANG Jun, CAI Zhenxiao, SUI Qian

Journal Article

functional supramolecular nanoparticles based on pillar[5]arene for controlled generation, storage and release

Journal Article

Phosphorus release potential and pollution characteristics of sediment in downstream Nansi Lake, China

Zhijian LI, Qinyan YUE, Baoyu GAO, Yanwen WANG, Qing LIU

Journal Article

Prevalence of antifolate drug resistance markers in in China

Journal Article

Clinical analysis of 275 cases of acute drug-induced liver disease

LI Lei, JIANG Wei, WANG Jiyao

Journal Article