Tumor is a global challenge that brings serious harm to human health. Early detection and effective treatment of tumors are difficult. With the development of science and technology, more and more new diagnostic methods and novel therapeutic strategies have emerged. The background of the cover is a tumor cell with abundant blood supply. The magnifying glass, drugs, and scalpel in the central bubble represent the diagnosis and therapy of tumor. The bubbles around the center bubble represent emerging technologies, and six representative new technologies are shown in clockwise: liquid biopsy, patient-derived tumor xenograft, multi-omics analysis, artificial intelligence in medical imaging, organoids, and nanomedicine.