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2021, Vol.7, Issue.10

On the cover

Tumor is a global challenge that brings serious harm to human health. Early detection and effective treatment of tumors are difficult. With the development of science and technology, more and more new diagnostic methods and novel therapeutic strategies have emerged. The background of the cover is a tumor cell with abundant blood supply. The magnifying glass, drugs, and scalpel in the central bubble represent the diagnosis and therapy of tumor. The bubbles around the center bubble represent emerging technologies, and six representative new technologies are shown in clockwise: liquid biopsy, patient-derived tumor xenograft, multi-omics analysis, artificial intelligence in medical imaging, organoids, and nanomedicine.

Guest Editorial Board

Guest Editorial Board

Guest Editors-in-Chief

Hongyang Wang, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, China

Shengli Yang, Shanghai Academician Center, China

Manfred Schwab, Editor-in-chief of Cancer Letters, Germany

Executive Editors-in-Chief

Guangwen Cao, Naval Medical University, China

Lei Chen, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, China

Members

Rene Bernards, The Netherlands Cancer Institute, The Netherlands

Webster Cavenee, Ludwig Cancer Research, USA

Zigang Dong, Zhengzhou University, China

Annica K.B. Gad, University of Sheffield, UK

Min Li, Oklahoma State University, USA

Cun-Yu Wang, University of California, Los Angeles, USA

Wen Wen, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, China

Qiang Xia, Renji Hospital, Shanghai Jiaotong University School of Medicine, China


Contents Volume 7 · Issue 10 · 2021. Pages 1343-1506 19 articles

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Editorial

Editorial for the Special Issue on New Technology for Tumor Diagnosis and Treatment

Hongyang Wang, Shengli Yang

Engineering 2021, Volume 7, Issue 10,   Pages 1343-1344 doi:10.1016/j.eng.2021.08.002

Abstract 1045 PDF 111

News & Highlights

SpaceX Starship Lands on Earth, But Manned Missions to Mars Will Require More

Chris Palmer

Engineering 2021, Volume 7, Issue 10,   Pages 1345-1347 doi:10.1016/j.eng.2021.08.005

Abstract 521 PDF 105

Texas Crisis Highlights Grid Vulnerabilities

Mitch Leslie

Engineering 2021, Volume 7, Issue 10,   Pages 1348-1350 doi:10.1016/j.eng.2021.08.007

Abstract 559 PDF 64

AI-Driven Robotic Laboratories Show Promise

Sean O´Neill

Engineering 2021, Volume 7, Issue 10,   Pages 1351-1353 doi:10.1016/j.eng.2021.08.006

Abstract 860 PDF 166

Research

New Technology of Tumor Diagnosis and Treatment

Inhibition of FLT3: A Prototype for Molecular Targeted Therapy in Acute Myeloid Leukemia Review

Meira Yisraeli Salman, Jacob M. Rowe, Nir Weigert

Engineering 2021, Volume 7, Issue 10,   Pages 1354-1368 doi:10.1016/j.eng.2021.05.020

Abstract 1000 PDF 64

Novel Non-Protein Biomarkers for Early Detection of Hepatocellular Carcinoma Review

Ghassan K. Abou-Alfa, Lin Wu, Augusto Villanueva

Engineering 2021, Volume 7, Issue 10,   Pages 1369-1374 doi:10.1016/j.eng.2021.02.020

Abstract 893 PDF 68

The Fibrillar Matrix: Novel Avenues for Breast Cancer Detection and Treatment Review

Rasha Rezk,  Raquel Marín-García,  Annica K.B.Gad

Engineering 2021, Volume 7, Issue 10,   Pages 1375-1380 doi:10.1016/j.eng.2021.04.024

Abstract 873 PDF 62

Distinct Immune Signatures in Peripheral Blood Predict Chemosensitivity in Intrahepatic Cholangiocarcinoma Patients Article

Tong Wu, Ying-Cheng Yang, Bo Zheng, Xue-Bing Shi, Wei Li, Wen-Cong Ma, Shan Wang, Zhi-Xuan Li, Yan-Jing Zhu, Jian-Min Wu, Kai-Ting Wang, Yan Zhao, Rui Wu, Cheng-Jun Sui, Si-Yun Shen, Xuan Wu, Lei Chen, Zhen-Gang Yuan, Hong-Yang Wang

Engineering 2021, Volume 7, Issue 10,   Pages 1381-1393 doi:10.1016/j.eng.2021.01.014

Abstract 876 PDF 55

Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer Article

Ana Montero-Calle, Itziar Aranguren-Abeigon, María Garranzo-Asensio, Carmen Poves, María Jesús Fernández-Aceñero, Javier Martínez-Useros, Rodrigo Sanz, Jana Dziaková, Javier Rodriguez-Cobos, Guillermo Solís-Fernández, Eloy Povedano, Maria Gamella, Rebeca Magnolia Torrente-Rodríguez, Miren Alonso-Navarro, Vivian de los Ríos, J. Ignacio Casal, Gemma Domínguez, Ana Guzman-Aranguez, Alberto Peláez-García, José Manuel Pingarrón, Susana Campuzano, Rodrigo Barderas

Engineering 2021, Volume 7, Issue 10,   Pages 1393-1412 doi:10.1016/j.eng.2021.04.026

Abstract 729 PDF 47

Exosomal CD44 Cooperates with Integrin α6β4 to Support Organotropic Metastasis via Regulating Tumor Cell Motility and Target Host Cell Activation Article

Wei Mu, Yajie Xu, Pengfei Gu, Wenbo Wang, Jingquan Li, Yang Ge, Hui Wang

Engineering 2021, Volume 7, Issue 10,   Pages 1415-1425 doi:10.1016/j.eng.2020.08.013

Abstract 1250 PDF 76

Effects of Three-Dimensional Platform Stiffness and Layer Dimensions on Separation of Carcinoma Cells Article

W.G. Zhang, Z.Y. Liu, S.W. Pang

Engineering 2021, Volume 7, Issue 10,   Pages 1426-1435 doi:10.1016/j.eng.2020.09.010

Abstract 693 PDF 34

A Smart Procedure for the Femtosecond Laser-Based Fabrication of a Polymeric Lab-on-a-Chip for Capturing Tumor Cell Article

Annalisa Volpe, Udith Krishnan, Maria Serena Chiriacò, Elisabetta Primiceri, Antonio Ancona, Francesco Ferrara

Engineering 2021, Volume 7, Issue 10,   Pages 1436-1442 doi:10.1016/j.eng.2020.10.012

Abstract 724 PDF 59

Coronavirus Disease 2019

Mass Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Camouflaging Glycans and Unique Post-Translational Modifications Article

Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li

Engineering 2021, Volume 7, Issue 10,   Pages 1441-1451 doi:10.1016/j.eng.2020.07.014

Abstract 517 PDF 55

Clinical Characteristics and Outcomes of Severe or Critical COVID-19 Patients Presenting No Respiratory Symptoms or Fever at Onset Article

Juanjuan Xu, Zhengrong Yin, Yu Liu, Sufei Wang, Limin Duan, Yi An, Jinshuo Fan, Tingting Liao, Yang Jin, Jianguo Chen

Engineering 2021, Volume 7, Issue 10,   Pages 1454-1460 doi:10.1016/j.eng.2020.09.009

Abstract 212 PDF 32

Advanced Measuring Instrument

A Predictive Instrument for Sensitive and Expedited Measurement of Ultra-Barrier Permeation Article

Jianfeng Wanyan, Kun Cao, Zhiping Chen, Yun Li, Chenxi Liu, Runqing Wu, Xiao-Dong Zhang, Rong Chen

Engineering 2021, Volume 7, Issue 10,   Pages 1461-1470 doi:10.1016/j.eng.2021.02.017

Abstract 1045 PDF 68

Energy Batteries

Co-Estimation of State of Charge and Capacity for Lithium-Ion Batteries with Multi-Stage Model Fusion Method Article

Rui Xiong, Ju Wang, Weixiang Shen, Jinpeng Tian, Hao Mu

Engineering 2021, Volume 7, Issue 10,   Pages 1471-1484 doi:10.1016/j.eng.2020.10.022

Abstract 390 PDF 95

Optical Neural Networks

Diffractive Deep Neural Networks at Visible Wavelengths Article

Hang Chen, Jianan Feng, Minwei Jiang, Yiqun Wang, Jie Lin, Jiubin Tan, Peng Jin

Engineering 2021, Volume 7, Issue 10,   Pages 1485-1493 doi:10.1016/j.eng.2020.07.032

Abstract 1443 PDF 320

Material Science and Engineering

Engineered Hybrid Materials with Smart Surfaces for Effective Mitigation of Petroleum-originated Pollutants Review

Nisar Ali, Muhammad Bilal, Adnan Khan,  Farman Ali, Mohamad Nasir Mohamad Ibrahim, Xiaoyan Gao, Shizhong Zhang, Kun Hong,  Hafiz M. N. Iqbal

Engineering 2021, Volume 7, Issue 10,   Pages 1494-1505 doi:10.1016/j.eng.2020.07.024

Abstract 765 PDF 79

Erratum to “After Highflyer Crashes, Airborne Wind Energy Regroups” [Engineering 7 (2021) 277–279]

Peter Weiss

Engineering 2021, Volume 7, Issue 10,   Pages 1506-1506 doi:10.1016/j.eng.2021.08.004

Abstract 269 PDF 29