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Effects of 3-aminobenzamide on poly (ADP-ribose) polymerase expression, apoptosis and cell cycle progression

DU Xiang, ZHAO Hongguang, GUO Wei, GONG Shouliang, WANG Wen

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 204-206 doi: 10.1007/s11684-008-0039-5

Abstract: aminobenzamide (3-AB) and the mechanisms of PARP action on HeLa cells damaged by irradiation.percentage of HeLa cells with positive expression of PARP protein 2, 4, 8 and 12 h after administrated with 3-ABAB was significantly lower than that of the control ( < 0.01).The percentages of apoptotic cells in the 3-AB plus irradiation group at the time points of 2, 8, 12It indicates that 3-AB can rapidly inhibit PARP expression of HeLa cells, promote cell apoptosis and

Keywords： control     irradiation     apoptotic     progression     3-AB    

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Ternary phase behavior of water microemulsified diesel-palm biodiesel

Nurul Atiqah Izzati MD ISHAK,Ismail Ab RAMAN,Mohd Ambar YARMO,Wan Mohd Faizal WAN MAHMOOD

Frontiers in Energy 2015, Volume 9, Issue 2,   Pages 162-169 doi: 10.1007/s11708-015-0355-9

Abstract: This paper aims to develop a new microemulsions system comprising diesel and palm oil methyl ester (PME) that have the potential to be used as alternative fuels for diesel engines. The water-in-diesel-biodiesel microemulsions were prepared by applying PME mixed with diesel, non-ionic surfactants, co-surfactants and water to make the water-in-oil (W/O) microemulsion system. This microemulsified fuel was achieved through low-energy microemulsification by using the constant composition method. The diesel used was mixed with four different concentrations of PME, i.e., 10% (w/w) (B10), 20% (w/w) (B20), 30% (w/w) (B30) and neat diesel (B0). The amount of water was fixed at 20% (w/w). The phase behavior of the water/mixed non-ionic surfactant/diesel-PME system were studied by constructing pseudoternary phase diagrams with the goal of formulating optimized systems. The results showed that the microemulsions were formed and stabilized with a mixture of non-ionic surfactants at a weight ratio of 80:20 at 20% (w/w), and with mixed co-surfactants at a weight ratio of 25:75, 20:80 and 10:90 for B0, B10, B20 and B30 respectively. The particle size, kinematic viscosity at 40°C, refractive index, density, heating value, cloud point, pour point and flash point of the selected water-in-diesel microemulsion were 19.40 nm (polydispersity of 0.12), 2.86 mm /s, 1.435, 0.8913 g/mL, 31.87 MJ/kg, 7.15°C, 10.5°C and 46.5°C respectively. The corresponding values of the water-in-diesel-PME selected were 20.72 nm to 23.74 nm, 13.02 mm /s to 13.29 mm /s, 1.442, 0.8939 g/mL to 0.8990 g/mL, 31.45 MJ/kg to 27.34 MJ/kg, 7.2°C to 6.8°C, 8.5°C to 1.5°C and 47.5°C to 52.0°C. These preliminary findings were further studied as potential fuels for diesel engines.

Keywords： palm methyl ester     palm oil biodiesel     microemulsion     water microemulsified fuels    

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Discovering optimal features using static analysis and a genetic search based method for Android malware detection None

Ahmad FIRDAUS, Nor Badrul ANUAR, Ahmad KARIM, Mohd Faizal Ab RAZAK

Frontiers of Information Technology & Electronic Engineering 2018, Volume 19, Issue 6,   Pages 712-736 doi: 10.1631/FITEE.1601491

Abstract: Mobile device manufacturers are rapidly producing miscellaneous Android versions worldwide. Simultaneously, cyber criminals are executing malicious actions, such as tracking user activities, stealing personal data, and committing bank fraud. These criminals gain numerous benefits as too many people use Android for their daily routines, including important communications. With this in mind, security practitioners have conducted static and dynamic analyses to identify malware. This study used static analysis because of its overall code coverage, low resource consumption, and rapid processing. However, static analysis requires a minimum number of features to efficiently classify malware. Therefore, we used genetic search (GS), which is a search based on a genetic algorithm (GA), to select the features among 106 strings. To evaluate the best features determined by GS, we used five machine learning classifiers, namely, Naïve Bayes (NB), functional trees (FT), J48, random forest (RF), and multilayer perceptron (MLP). Among these classifiers, FT gave the highest accuracy (95%) and true positive rate (TPR) (96.7%) with the use of only six features.

Keywords： Genetic algorithm     Static analysis     Android     Malware     Machine learning    

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Thermal and Mechanical Properties Optimization of ABO4 Type EuNbO4 By the Article

Lin Chen, Jing Feng

Engineering 2020, Volume 6, Issue 2,   Pages 177-184 doi: 10.1016/j.eng.2019.12.006

Abstract:

Ferroelastic ABO4 type RETaO4 and RENbO4 ceramics (where

Keywords： Thermal barrier coatings     Rare earth niobates     Substitution     Thermal conductivity     Thermal expansion coefficients     Young’s modulus    

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Synthesis of copolymers of 3-acryloyloxymethyl-3′-methyloxetane and 3-(2-(2-(2-Methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane and their ionic conductivity properties

YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng

Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 4,   Pages 343-348 doi: 10.1007/s11705-007-0062-0

Abstract: An oxetane-derived monomer, 3-acryloyloxymethyl-3′-methyloxetane (AMO) was prepared from the reactionof 3-hydromethyl-3-methyloxetane with acryloyl chloride.The cationic ring-opening copolymerization of AMO with another oxetane-derived monomer, 3-(2-(2-(2-methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane (MEMO) was conducted in CHCl solution using BF3 ·OEt/1, 4-butanediol

Keywords： 4-butanediol     2-methoxyethylenoxy     consistent     oxetane-derived     copolymer    

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Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 95-99 doi: 10.1007/s11684-008-0017-y

Abstract: The Sj14-3-3 gene was amplified and subcloned into the expression vector pPICZ?The protein of rSj14-3-3 was prepared and purified and BALB/c mice were immunized which was followedThe Sj14-3-3 gene was expressed and secreted into the medium and its molecular weight was about 35000antibody and rSj14-3-3 had a promising immune reactivity.The recombinant Sj14-3-3 of eukaryotic expression in was successfully harvested.

Keywords： development     challenging     rSj14-3-3     resistance     cultural supernatant    

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第四届高性能编译、计算和通信国际会议(HP3C 2020)

Conference Date: 12 Mar 2020

Conference Place: 广东广州

Administered by: HP3C 2020

FOXP3 and Its Cofactors as Targets of Immunotherapies Review

Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang

Engineering 2019, Volume 5, Issue 1,   Pages 115-121 doi: 10.1016/j.eng.2019.01.001

Abstract:

Forkhead box P3 (FOXP3) is a "master regulator" of regulatory T cells (Tregs), which areAs a consequence, the PTMs change the stability of FOXP3 and its capability to regulate gene expressionAlthough FOXP3 per se is not an ideal drug target, deacetylases, acetyltransferases, kinases, and other enzymes that regulate the PTMs of FOXP3 are potential targets to modulate FOXP3 and TregFOXP3" side effects must be considered when inhibitors to these enzymes are used.

Keywords： Treg     Forkhead box P3 (FOXP3)     Post-translational modification     Autoimmune     Cancer    

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Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and

Frontiers of Medicine doi: 10.1007/s11684-023-1003-0

Abstract: However, little is known about the function of Lipin3 in triglyceride (TG) metabolism.Hence, we generated Lipin3 heterozygous knockout (Lipin3-heKO) mice and cultured primary hepatocytesto explore the pathophysiological roles of Lipin3 in TG metabolism.Our study suggested that Lipin3 was a novel disease-causing gene inducing obesity and HTG.We also established a relationship between Lipin3 and mitochondrial dysfunction.

Keywords： Lipin3     Lipin1     hypertriglyceridemia     obesity     mitochondrial dysfunction    

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A Review on the 3D Printing of Functional Structures for Medical Phantoms and Regenerated Tissue and

Kan Wang, Chia-Che Ho, Chuck Zhang, Ben Wang

Engineering 2017, Volume 3, Issue 5,   Pages 653-662 doi: 10.1016/J.ENG.2017.05.013

Abstract: With the rapid advancement of three-dimensional (3D) printing and 3D bioprinting technologies, many researchersThis paper reviews the applications of these 3D printing and 3D bioprinting technologies for the fabricationThis review specifically discusses the state of the art along with new developments and trends in 3Dmedical phantoms, radiologically relevant medical phantoms, and physiological medical phantoms) and 3D

Keywords： 3D printing     3D bioprinting     Medical phantom     Regenerated tissue/organ     Scaffold    

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2020第四届环境与能源工程国际会议(IC3E 2020)

Conference Date: 12 Mar 2020

Conference Place: 海南海口 三亚

Administered by: APISE

Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 269-273 doi: 10.1007/s11684-007-0051-1

Abstract: investigate the influence and the related mechanism of the gene on glucose uptake and insulin resistance in 3T3Radioimmunoassay was used to determine glucose uptake in 3T3-L1 cells with different gene expressionreal-time RT-PCR analysis were used to determine the mRNA levels of several glucose transport proteins in 3T3and glycogen synthase kinase-3b (GSK-3)., GSK-3 and p38MAPK, increased with overexpression in 3T3-L1 cells.

Keywords： 3T3-L1     influence     resistance     receptor substrate-1     transport    

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Fatigue Strength Evaluation of Resin-Injected Bolted Connections Using Statistical Analysis

oacute;nio Fonseca de Oliveira Correia, Bruno Alexandre Silva Pedrosa, Patrícia Cordeiro Raposo, Ab

Engineering 2017, Volume 3, Issue 6,   Pages 795-805 doi: 10.1016/j.eng.2017.12.001

Abstract: Since Eurocode 3 (EC3) suggests the same fatigue strength curve for joints made of resin-injected bolts

Keywords： Fatigue     Connections     Structural reinforcements     Structural adhesives     S-N curves     Resin-injected bolts    

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Combustion and emissions of RP-3 jet fuel and diesel fuel in a single-cylinder diesel engine

Frontiers in Energy 2023, Volume 17, Issue 5,   Pages 664-677 doi: 10.1007/s11708-021-0787-3

Abstract: The combustion characteristics and emission behaviors of RP-3 jet fuel were studied and compared to commercialcrank angle (CA) after top dead center (ATDC)) were adjusted to evaluate the engine performances of RP-3In comparison to diesel fuel, RP-3 jet fuel shows a retarded heat release and lagged combustion phaseAs a result, RP-3 jet fuel features a longer ignition delay (ID) time, a shorter combustion durationCompared with diesel fuel, the nitrogen oxides (NOx) emissions of RP-3 jet fuel are

Keywords： RP-3 jet fuel     diesel     engine     combustion     emissions    

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Title Author Date Type Operation

Effects of 3-aminobenzamide on poly (ADP-ribose) polymerase expression, apoptosis and cell cycle progression

DU Xiang, ZHAO Hongguang, GUO Wei, GONG Shouliang, WANG Wen

Journal Article

Ternary phase behavior of water microemulsified diesel-palm biodiesel

Nurul Atiqah Izzati MD ISHAK,Ismail Ab RAMAN,Mohd Ambar YARMO,Wan Mohd Faizal WAN MAHMOOD

Journal Article

Discovering optimal features using static analysis and a genetic search based method for Android malware detection

Ahmad FIRDAUS, Nor Badrul ANUAR, Ahmad KARIM, Mohd Faizal Ab RAZAK

Journal Article

Thermal and Mechanical Properties Optimization of ABO4 Type EuNbO4 By the

Lin Chen, Jing Feng

Journal Article

Xiaohan: Traditional Chinese Medicine Talks About Health, Dietary Supplement and Improving Immunity (2020-3-

18 Apr 2022

Conference Videos

Synthesis of copolymers of 3-acryloyloxymethyl-3′-methyloxetane and 3-(2-(2-(2-Methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane and their ionic conductivity properties

YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng

Journal Article

Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

Journal Article

第四届高性能编译、计算和通信国际会议(HP3C 2020)

12 Mar 2020

Conference Information

FOXP3 and Its Cofactors as Targets of Immunotherapies

Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang

Journal Article

Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and

Journal Article

A Review on the 3D Printing of Functional Structures for Medical Phantoms and Regenerated Tissue and

Kan Wang, Chia-Che Ho, Chuck Zhang, Ben Wang

Journal Article

2020第四届环境与能源工程国际会议(IC3E 2020)

12 Mar 2020

Conference Information

Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Journal Article

Fatigue Strength Evaluation of Resin-Injected Bolted Connections Using Statistical Analysis

oacute;nio Fonseca de Oliveira Correia, Bruno Alexandre Silva Pedrosa, Patrícia Cordeiro Raposo, Ab

Journal Article

Combustion and emissions of RP-3 jet fuel and diesel fuel in a single-cylinder diesel engine

Journal Article