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《环境科学与工程前沿(英文)》 2022年 第16卷 第7期 doi: 10.1007/s11783-021-1447-x
• The optimum SCR activity was realized by tuning the acid pretreatment.
关键词: Air pollution control Nitrogen oxides Selective catalytic reduction Red mud Solid waste utilization
The microRNA, miR-29c, participates in muscle development through targeting the
Weiya ZHANG,Wei WEI,Yuanyuan ZHAO,Shuhong ZHAO,Xinyun LI
《农业科学与工程前沿(英文)》 2015年 第2卷 第4期 页码 311-317 doi: 10.15302/J-FASE-2015075
Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review
《化学科学与工程前沿(英文)》 2023年 第17卷 第2期 页码 123-138 doi: 10.1007/s11705-022-2194-7
关键词: NAD(P)H:quinone oxidoreductase 1 cancer therapy target probe nanosystem
Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng
《化学科学与工程前沿(英文)》 2020年 第14卷 第5期 页码 889-901 doi: 10.1007/s11705-020-1919-8
关键词: gene carriers multitargeting function ECs transfection efficiency
Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma
《医学前沿(英文)》 2023年 第17卷 第2期 页码 290-303 doi: 10.1007/s11684-022-0956-8
关键词: benzydamine cyclin-dependent kinase 2 patient-derived xenograft esophageal squamous cell carcinoma
Rhizosphere immunity: targeting the underground for sustainable plant health management
Zhong WEI, Ville-Petri FRIMAN, Thomas POMMIER, Stefan GEISEN, Alexandre JOUSSET, Qirong SHEN
《农业科学与工程前沿(英文)》 2020年 第7卷 第3期 页码 317-328 doi: 10.15302/J-FASE-2020346
Managing plant health is a great challenge for modern food production and is further complicated by the lack of common ground between the many disciplines involved in disease control. Here we present the concept of rhizosphere immunity, in which plant health is considered as an ecosystem level property emerging from networks of interactions between plants, microbiota and the surrounding soil matrix. These interactions can potentially extend the innate plant immune system to a point where the rhizosphere immunity can fulfil all four core functions of a full immune system: pathogen prevention, recognition, response and homeostasis. We suggest that considering plant health from a meta-organism perspective will help in developing multidisciplinary pathogen management strategies that focus on steering the whole plant-microbe-soil networks instead of individual components. This might be achieved by bringing together the latest discoveries in phytopathology, microbiome research, soil science and agronomy to pave the way toward more sustainable and productive agriculture.
关键词: rhizosphere soil microbiome plant immunity microbial ecology plant health soilborne pathogens
Ruiting Han, Junli Ma, Houkai Li
《医学前沿(英文)》 2018年 第12卷 第6期 页码 645-657 doi: 10.1007/s11684-018-0645-9
关键词: gut microbiota NAFLD obesity insulin resistance bile acids probiotic
MicroRNA-148b promotes proliferation of hair follicle cells by targeting
Wanbao YANG,Qinqun LI,Bo SU,Mei YU
《农业科学与工程前沿(英文)》 2016年 第3卷 第1期 页码 72-80 doi: 10.15302/J-FASE-2016089
Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng
《化学科学与工程前沿(英文)》 2021年 第15卷 第1期 页码 220-220 doi: 10.1007/s11705-020-1995-9
Jianwen CHEN, Kaiyuan PAN, Zhen CHEN, Biao DING, Dandan SONG, Wenbin BAO, Yunhai ZHANG
《农业科学与工程前沿(英文)》 2019年 第6卷 第1期 页码 66-72 doi: 10.15302/J-FASE-2018229
Porcine viral diarrhea is an acute and highly contagious enteric disease of pigs that causes huge economic losses worldwide. Porcine epidemic diarrhea virus (PEDV) and transmissible gastroenteritis virus (TGEV) are the main pathogens responsible for piglet viral diarrhea. However, currently there is no specific drug available for the effective treatment of viral diarrhea. Therefore, it is necessary to seek an effective method to diminish PEDV and TGEV infection rates. RNA interference has been applied successfully to inhibit the virus replication. It provides a potential strategy for breeding resistant pigs. In this study, four promoters and four short hairpin RNA (shRNA) vectors with LoxP sites at each end of the selectable marker genes were constructed to target PEDV and TGEV. These vectors were then transfected into porcine fetal fibroblasts, G418 resistant transfectants were confirmed by PCR and transgenic SCNT porcine blastocysts were obtained. These results have paved the way for future production of marker-free transgenic resistant to PEDV and TEGV pigs by SCNT.
关键词: piglet diarrhea RNAi PEDV TGEV transgenic resistance breeding
null
《医学前沿(英文)》 2017年 第11卷 第4期 页码 449-461 doi: 10.1007/s11684-017-0589-5
In recent years, unexpected outbreaks of infectious diseases caused by emerging and re-emerging viruses have become more frequent, which is possibly due to environmental changes. These outbreaks result in the loss of life and economic hardship. Vaccines and therapeutics should be developed for the prevention and treatment of infectious diseases. In this review, we summarize and discuss the latest progress in the development of small-molecule viral inhibitors against highly pathogenic coronaviruses, including severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus, Ebola virus, and Zika virus. These viruses can interfere with the specific steps of viral life cycle by blocking the binding between virus and host cells, disrupting viral endocytosis, disturbing membrane fusion, and interrupting viral RNA replication and translation, thereby demonstrating potent therapeutic effect against various emerging and re-emerging viruses. We also discuss some general strategies for developing small-molecule viral inhibitors.
关键词: emerging and re-emerging viruses small-molecule inhibitor coronavirus Ebola virus Zika virus life cycle
ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen
《医学前沿(英文)》 2008年 第2卷 第1期 页码 19-24 doi: 10.1007/s11684-008-0005-2
关键词: therapy Sprague administration cardiac hypertrophy valsartan
Gene silencing efficiency of shRNA expression vectors targeting Cx43
Cuihong ZHENG, Yunxia WU, Guangying HUANG, Wei WANG
《医学前沿(英文)》 2009年 第3卷 第2期 页码 130-135 doi: 10.1007/s11684-009-0030-9
关键词: RNA interference connexin 43 small hairpin RNA (shRNA) acupuncture
SU Yuan, JIN Yang, ZHANG Xiaoju, ZHOU Qiong, BAI Ming, ZHU Liping
《医学前沿(英文)》 2007年 第1卷 第4期 页码 359-363 doi: 10.1007/s11684-007-0069-4
Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer
null
《医学前沿(英文)》 2017年 第11卷 第2期 页码 214-222 doi: 10.1007/s11684-017-0518-7
MicroRNAs (miRNAs) play critical roles in the development and progression in various cancers. Dysfunctional miR-9 expression remains ambiguous, and no consensus on the metastatic progression of ovarian cancer has been reached. In this study, results from the bioinformatics analysis show that the 3′-UTR of the E-cadherin mRNA was directly regulated by miR-9. Luciferase reporter assay results confirmed that miR-9 could directly target this 3′-UTR. miR-9 and E-cadherin expression in ovarian cancer tissue was quantified by qRT-PCR. Migration and invasion were detected by wound healing and Transwell system assay in SKOV3 and A2780. qRT-PCR and Western blot were performed to detect the epithelial?mesenchymal transition-associated mRNA and proteins. Immunofluorescence technique was used to analyze the expression and subcellular localization of E-cadherin, N-cadherin, and vimentin. The results showed that miR-9 was frequently upregulated in metastatic serous ovarian cancer tissue compared with paired primary ones. Upregulation of miR-9 could downregulate the expression of E-cadherin but upregulate the expression of mesenchymal markers (N-cadherin and vimentin). Overexpression of miR-9 could promote the cell migration and invasion in ovarian cancer, and these processes could be effectively inhibited via miR-9 inhibitor. Thus, our study demonstrates that miR-9 may promote ovarian cancer metastasis via targeting E-cadherin and a novel potential therapeutic approach to control metastasis of ovarian cancer.
标题 作者 时间 类型 操作
Precise regulation of acid pretreatment for red mud SCR catalyst: Targeting on optimizing the acidity
期刊论文
The microRNA, miR-29c, participates in muscle development through targeting the
Weiya ZHANG,Wei WEI,Yuanyuan ZHAO,Shuhong ZHAO,Xinyun LI
期刊论文
Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting, penetrating
Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng
期刊论文
Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma
期刊论文
Rhizosphere immunity: targeting the underground for sustainable plant health management
Zhong WEI, Ville-Petri FRIMAN, Thomas POMMIER, Stefan GEISEN, Alexandre JOUSSET, Qirong SHEN
期刊论文
Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota
Ruiting Han, Junli Ma, Houkai Li
期刊论文
MicroRNA-148b promotes proliferation of hair follicle cells by targeting
Wanbao YANG,Qinqun LI,Bo SU,Mei YU
期刊论文
Erratum to: Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting
Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng
期刊论文
Construction of multiple shRNA vectors targeting PEDV and TGEV and production of transgenic SCNT porcine
Jianwen CHEN, Kaiyuan PAN, Zhen CHEN, Biao DING, Dandan SONG, Wenbin BAO, Yunhai ZHANG
期刊论文
Development of small-molecule viral inhibitors targeting various stages of the life cycle of emerging
null
期刊论文
Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy
ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen
期刊论文
Gene silencing efficiency of shRNA expression vectors targeting Cx43
Cuihong ZHENG, Yunxia WU, Guangying HUANG, Wei WANG
期刊论文
Impact of siRNA targeting pirh2 on proliferation and cell cycle control of the lung adenocarcinoma cell
SU Yuan, JIN Yang, ZHANG Xiaoju, ZHOU Qiong, BAI Ming, ZHU Liping
期刊论文