Search | Engineering

订阅投稿

首页学术期刊学术焦点学术视频工程成就工程前沿联系我们 English

资源类型

期刊论文 172

会议视频 5

会议信息 1

年份

2023 2

2022 14

2021 25

2020 5

2019 18

2018 13

2017 5

2016 13

2015 11

2014 8

2013 8

2012 13

2011 7

2010 7

2009 11

2008 1

2007 2

2000 2

展开︾

关键词

癌症 6

医学 4

结直肠癌 3

临床试验 2

乳腺癌 2

人工智能 2

免疫疗法 2

外泌体 2

糖尿病 2

肿瘤 2

调节性T细胞 2

BNCT 1

Beclin-1 1

CD44 1

HIFU 1

MCF-7细胞球 1

NOG小鼠 1

SEER数据库，生存分析，印戒细胞癌，转移，结直肠癌，胃癌 1

下一代测序 1

展开︾

检索范围：

排序：展示方式：

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

《医学前沿（英文）》 2021年第15卷第6期页码 942-942 doi: 10.1007/s11684-021-0876-z

HTML PDF 收藏

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

null

《医学前沿（英文）》 2016年第10卷第1期页码 41-51 doi: 10.1007/s11684-016-0429-z

摘要：

Midline2 (MID2) is an ubiquitin-conjugating E2 enzyme linked to tumor progression and a novel interacting partner of breast cancer 1, early-onset (BRCA1). However, the role of MID2 in breast cancer remains unknown. This study investigated the expression, prognostic value, and role of MID2 in breast cancer. The expression of MID2 mRNA and protein was significantly upregulated in breast cancer tissue and established cell lines compared with that in normal breast epithelial cells and paired adjacent non-tumor tissue (P<0.001). Immunohistochemical analysis demonstrated that MID2 was overexpressed in 272 of 284 (95.8%) paraffin-embedded, archived breast cancer tissue. Moreover, MID2 expression increased with advanced clinical stage (P<0.001). High MID2 expression was significantly associated with advanced clinical stages and T, N, and M staging (all P<0.05). Univariate and multivariate analyses indicated that high MID2 expression was an independent prognostic factor for poor overall survival in the entire cohort (93.73 vs. 172.1 months; P<0.001, log-rank test) and in subgroups with stages Tis+ I+ II and III+ IV. Furthermore, 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide colony formation, and anchorage-independent growth ability assays were conducted. Results showed that siRNA silencing of MID2 expression significantly reduced MCF-7 and MDA-MB-231 cell proliferation in vitro and blocked the growth of MDA-MB-231 cell xenograft tumors in vivo (P<0.05). This study indicated that MID2 may be a novel prognostic marker and interventional target in breast cancer.

关键词： breast cancer MID2 proliferation overall survival xenograft

HTML PDF 收藏

Meta-analysis of the risk factors of breast cancer concerning reproductive factors and oral contraceptive

Qiong DAI MD, Bei LIU MD, Yukai DU MM,

《医学前沿（英文）》 2009年第3卷第4期页码 452-458 doi: 10.1007/s11684-009-0080-z

摘要： The authors performed a meta-analysis of case-control studies that addressed whether reproductive factors and oral contraceptive use were associated with breast cancer by searching the MEDLINE, PubMed, Proquest, Embase, ScienceDirect, African Healthline, BMJ Health Intelligence and Chinese Periodical net databases for all English-language and Chinese-language papers published from January 1, 1997 to December 31, 2007. A total of 15 studies calculating pool ORs indicated that menopausal age >50yr [odds ratio (OR), 1.39; 95% confidence interval (CI), 1.22―1.57] and oral contraceptive use (OR, 2.12*, “*”: summary OR was adjusted; 95% CI, 1.24―3.62) were correlated with the increase in breast cancer risk while the summary OR based on number of full-term pregnancies ≥1 (OR, 0.63*; 95% CI, 0.60―0.68) and breast-feeding (OR, 0.76; 95% CI, 0.64―0.90) indicated no association with breast cancer risk. The correlation was statistically significant. Menopausal age >50yr and oral contraceptive use are positively correlated with an increase in breast cancer risk while breast-feeding and number of full-term pregnancies ≥1 are protective factors.

关键词： meta-analysis breast cancer risk factors reproductive factors oral contraceptive use

HTML PDF 收藏

Metabolism and immunity in breast cancer

Deyu Zhang, Xiaojie Xu, Qinong Ye

《医学前沿（英文）》 2021年第15卷第2期页码 178-207 doi: 10.1007/s11684-020-0793-6

摘要： Breast cancer is one of the most common malignancies that seriously threaten women’s health. In the process of the malignant transformation of breast cancer, metabolic reprogramming and immune evasion represent the two main fascinating characteristics of cancer and facilitate cancer cell proliferation. Breast cancer cells generate energy through increased glucose metabolism. Lipid metabolism contributes to biological signal pathways and forms cell membranes except energy generation. Amino acids act as basic protein units and metabolic regulators in supporting cell growth. For tumor-associated immunity, poor immunogenicity and heightened immunosuppression cause breast cancer cells to evade the host’s immune system. For the past few years, the complex mechanisms of metabolic reprogramming and immune evasion are deeply investigated, and the genes involved in these processes are used as clinical therapeutic targets for breast cancer. Here, we review the recent findings related to abnormal metabolism and immune characteristics, regulatory mechanisms, their links, and relevant therapeutic strategies.

关键词： breast cancer metabolism immunity cancer stem cells

HTML PDF 收藏

A comprehensive information database (CID) of breast cancer patients in China

null

《医学前沿（英文）》 2012年第6卷第2期页码 212-216 doi: 10.1007/s11684-012-0185-7

HTML PDF 收藏

Production of pectic extracts from sugar beet pulp with antiproliferative activity on a breast cancer

Jacqueline CONCHA, Caroline WEINSTEIN, María Elvira Zú?IGA

《化学科学与工程前沿（英文）》 2013年第7卷第4期页码 482-489 doi: 10.1007/s11705-013-1342-5

摘要： In the last years, sugar beet pectins have been the subject of several investigations involving extraction methodologies, chemical composition and functional properties. The structure of pectins, which depends on the extraction method, is decisive in their capacity to induce apoptosis on several cancer cell lines like colon, prostate and breast. In this work, sugar beet pectin extraction was performed in the following steps: lipid extraction with hexane, removal of soluble complex carbohydrates and proteins, and enzymatic treatment with amyloglucosidase, protease, and pectinase. The enzymatic treatment was carried out with Rohapect DA6L under the following conditions: 50°C, pH 4.0, 2% enzyme/substrate (E/S) ratio, 15 h, and a solid to liquid ratio of 1 ∶ 10. The pectic extract showed a degree of polymerization (DP) profile of 55.8% with DP≥7; 4.9% with DP6; 5.8% between DP2 and DP6 ; 4.7% with DP2; and 28.8% with DP1. The pectic extract was examined for its antiproliferative activity on the MCF-7 breast cancer cell line. At a concentration range of 12.5–25 mg/mL the pectic extract killed 80.6% of the cells, exhibiting a higher antiproliferative activity than 4-hydroxytamoxifen (4-OHT), a classical anticancer drug, which killed 56.5% of the cells.

关键词： pectic extracts antiproliferative activity breast cancer enzymatic treatment

HTML PDF 收藏

Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

null

《医学前沿（英文）》 2016年第10卷第1期页码 33-40 doi: 10.1007/s11684-016-0431-5

摘要：

Breast cancer is the most common malignant tumor in women, and the incidence of this disease has increased in recent years because of changes in diet, living environment, gestational age, and other unknown factors. Previous studies focused on cancer cells, but an increasing number of recent studies have analyzed the contribution of cancer microenvironment to the initiation and progression of breast cancer. Cancer-associated fibroblasts (CAFs), the most abundant cells in tumor stroma, secrete various active biomolecules, including extracellular matrix components, growth factors, cytokines, proteases, and hormones. CAFs not only facilitate the initiation, growth, angiogenesis, invasion, and metastasis of cancer but also serve as biomarkers in the clinical diagnosis, therapy, and prognosis of breast cancer. In this article, we reviewed the literature and summarized the research findings on CAFs in breast cancer.

关键词： cancer-associated fibroblast breast cancer progression prognosis

HTML PDF 收藏

Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

《医学前沿（英文）》 2021年第15卷第1期页码 1-10 doi: 10.1007/s11684-020-0741-5

摘要： Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with a heterogeneous genetic profile. Chemotherapy exhibits substantial activity in a small subset of these patients. Drug resistance is inevitable. Major progress has been made in the genetic analysis of TNBC to identify novel targets and increase the precision of therapeutic intervention. Such progress has translated into major advances in treatment strategies, including modified chemotherapy approaches, immune checkpoint inhibitors, and targeted therapeutic drugs. All of these strategies have been evaluated in clinical trials. Nevertheless, patient selection remains a considerable challenge in clinical practice.

关键词： triple-negative breast cancer immunotherapy targeted therapy

HTML PDF 收藏

Soy food consumption in relation to breast cancer modified by menopause status

YANG Rong, ZHANG Bin, YANG Shaoping, ZHANG Dan, DU Yukai

《医学前沿（英文）》 2008年第2卷第4期页码 348-351 doi: 10.1007/s11684-008-0066-2

摘要： It has been found that lifestyle and diet are associated with the development of cancers. The mortality of breast cancer in Wuhan city is increasing, according to the statistics of recent years. This case control study was aimed to provide data for alimentary therapeutics for breast carcinomas. It included a case group ( = 196) and an age frequency-matched control group ( = 202). A validated food frequency questionnaire was used to obtain information on usual food consumption. The results indicate that intake of soy foods more than 5 times per week was associated with a decreased risk of breast cancer, especially in premenopausal women. The adjusted was 0.294 [95% CI was (0.158–0.546), = 0.000]. Our results indicate that alimentary therapeutics for breast cancer can be adjusted by status of menopause.

关键词： development control lifestyle consumption information

HTML PDF 收藏

How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

《医学前沿（英文）》 2010年第4卷第3期页码 290-293 doi: 10.1007/s11684-010-0093-7

摘要： The relevance of postmenopausal hormone therapy (HT) for breast cancer risk has been long debated, although it is one of the most important barriers for women to accept HT. Various opinions have been reported from recent randomized clinical trials and epidemiological studies. These unanswered questions include: whether HT has a positive impact on breast cancer; whether risks of therapy with unopposed estrogen and combined estrogen-progestin are different; and whether different types and routes of estrogen and progestogens, as well as the duration and cessation of HT use, have different impacts on this disorder. Recently, there has been some good news such as the following: the currently available data do not provide sufficient evidence to prove a causal relationship between postmenopausal HT and breast cancer; breast cancer in postmenopausal women using HT usually has better prognosis than that of nonusers. In conclusion, HT is still the most effective method of relieving climacteric symptoms for many postmenopausal women. However, a possible risk of breast cancer associated with long-term HT usage should not be ignored. With respect to prevention of breast cancer, regular evaluation of individual breast cancer susceptibility and close follow-up through mammography and/or breast sonography are necessary strategies for the safety of HT use.

关键词： breast cancer postmenopausal hormone therapy unopposed estrogen therapy combined estrogen-progestin therapy

HTML PDF 收藏

Transformer2 proteins protect breast cancer cells from accumulating replication stress by ensuring productive

Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott

《化学科学与工程前沿（英文）》 2016年第10卷第2期页码 186-195 doi: 10.1007/s11705-015-1540-4

摘要： Increased expression levels of the RNA splicing regulator Transformer2 (abbreviated Tra2 ) have been reported in several types of cancer. Recent work has revealed an intimate cross-regulation between Tra2 and the highly similar Tra2 protein in human breast cancer cells, though these two proteins are encoded by separate genes created by a gene duplication that occurred over 500 million years ago. This cross-regulation involves splicing control of a special class of exons, called poison exons. Down-regulation of Tra2 reduces splicing inclusion of a poison exon in the mRNA encoding Tra2 , thereby up-regulating Tra2 protein expression. This buffers any splicing changes that might be caused by individual depletion of Tra2 alone. Discovery of this cross-regulation pathway, and its by-pass by joint depletion of both human Tra2 proteins, revealed Tra2 proteins are essential for breast cancer cell viability, and led to the identification of important targets for splicing control. These exons include a critical exon within the checkpoint kinase 1 (CHK1) gene that plays a crucial function in the protection of cancer cells from replication stress. Breast cancer cells depleted for Tra2 proteins have reduced CHK1 protein levels and accumulate DNA damage. These data suggest Tra2 proteins and/or their splicing targets as possible cancer drug targets.

关键词： RNA splicing gene expression breast cancer DNA damage CHK1

HTML PDF 收藏

Medical applications of phytoestrogens from the Thai herb

null

《医学前沿（英文）》 2012年第6卷第1期页码 8-21 doi: 10.1007/s11684-012-0184-8

摘要：

Pueraria mirifica Airy Shaw et Suvatabandhu is a medicinal plant endemic to Thailand. It has been used in Thai folklore medicine for its rejuvenating qualities in aged women and men for nearly one hundred years. Indeed, it has been claimed that P. mirifica contains active phytoestrogens (plant substances with estrogen-like activity). Using high performance liquid chromatography, at least 17 phytoestrogens, mainly isoflavones, have been isolated. Thus, fairly considerable scientific researches, both in vitro in cell lines and in vivo in various species of animals including humans, have been conducted to date to address its estrogenic activity on the reproductive organs, bones, cardiovascular diseases and other climacteric related symptoms. The antioxidative capacity and antiproliferative effect on tumor cell lines have also been assessed. In general, P. mirifica could be applicable for preventing, or as a therapeutic for, the symptoms related to estrogen deficiency in menopausal women as well as in andropausal men. However, the optimal doses for each desirable effect and the balance to avoid undesired side effects need to be calculated before use.

关键词： white Kwao Krua miroestrol estrogenic activity reproduction osteoporosis breast cancer Alzheimer

HTML PDF 收藏

纤维基质——乳腺癌检测和治疗的新途径 Review

Rasha Rezk, Raquel Marín-García, Annica K.B.Gad

《工程（英文）》 2021年第7卷第10期页码 1375-1380 doi: 10.1016/j.eng.2021.04.024

摘要：

乳腺癌的特点是肿瘤细胞周围的蛋白纤维大量增加。这些纤维会提高组织的机械硬度，人们一直以来都是利用这一点并通过手动触诊来诊断肿瘤。最近的生物工程研究开发了新型生物材料，这些材料模拟了肿瘤微环境的力学特性和结构特性，可以用来了解这些特性如何调节乳腺癌的发展和扩散。本文概述了乳腺癌组织的力学特性与正常乳腺组织及非癌性病变组织的力学特性之间的差异，描述了生物材料模型是如何用于了解细胞外环境的硬度和黏度调节细胞迁移和乳腺癌转移的。此外，本文还强调了对生物材料模型的需求，这些模型可独立分析肿瘤微环境的单个和多个力学特性并利用肿瘤内不同区域的细胞，同时为进行乳腺癌转移新型机械疗法的开发提供了指导。

关键词：乳腺癌组织硬度癌症转移细胞迁移生物工程支架黏度

HTML PDF 收藏

Effect of lanthanum chloride on growth of breast cancer cells and regulation of transcription

Xue LI MM , Ping HE MM , Jie XIA MM , Shiwei SONG BS , Jinhai LU BM , Yunde LIU MM ,

《医学前沿（英文）》 2009年第3卷第3期页码 336-340 doi: 10.1007/s11684-009-0053-2

摘要： Lanthanum salt is a prescription drug, but its underlying functions and mechanisms are not fully understood currently. To explore the potential therapeutic value of , cytotoxicity test was applied to investigate its effects on cell proliferation. Furthermore, we observed its influence on pro-oncogene by reverse transcription polymerase chain reaction (RT-PCR). In MCF-7 cell line, repressed cell proliferation at high concentration but had no significant inhibition effect on cell growth at low concentration. However, we observed that repressed transcription at a low concentration. This may suggest that is a potent drug to inhibit the high expression of in carcinoma cells and play a clue for inhibiting the growth and invasion of tumor.

关键词： proliferation c-met invasion lanthanum chloride

HTML PDF 收藏

Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

null

《医学前沿（英文）》 2013年第7卷第1期页码 138-142 doi: 10.1007/s11684-013-0247-5

摘要：

It has been demonstrated that single nucleotide polymorphisms (SNPs) of SIPA1 (signal-induced proliferation associated gene 1) are associated with metastatic efficiency in both human and rodents. The purpose of this study was to determine whether SIPA1 545 C>T polymorphism was associated with overall survival in patients with metastatic breast cancer. In this study, SIPA1 545 C>T polymorphism was detected in 185 metastatic breast cancer patients using polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP). Survival curves for patients with SIPA1 545 C>T polymorphism was compared using the Kaplan-Meier method with log-rank tests. We found that SIPA1 545 C>T polymorphism was significantly associated with survival in 185 patients with metastatic breast cancer. Patients with SIPA1545 T/T genotype had a significantly worse overall survival (OS) than did patients with C/T or C/C genotype (50.0% vs. 62.9%, P = 0.042). Moreover, in multivariate analysis, as compared with the C/C or C/T genotype, the T/T genotype remained an independent unfavorable prognostic marker of OS in this cohort (hazard ratio [HR] = 2.16; 95% CI= 1.12–4.15; P = 0.022). Our findings indicate that metastatic breast cancer patients with SIPA1 545 T/T genotype have a poorer survival compared to patients with C/C or C/T genotype.

关键词： SIPA1 polymorphism metastatic breast cancer survival

HTML PDF 收藏

标题作者时间类型操作

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

期刊论文

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

null

期刊论文

Meta-analysis of the risk factors of breast cancer concerning reproductive factors and oral contraceptive

Qiong DAI MD, Bei LIU MD, Yukai DU MM,

期刊论文

Metabolism and immunity in breast cancer

Deyu Zhang, Xiaojie Xu, Qinong Ye

期刊论文

A comprehensive information database (CID) of breast cancer patients in China

null

期刊论文

Production of pectic extracts from sugar beet pulp with antiproliferative activity on a breast cancer

Jacqueline CONCHA, Caroline WEINSTEIN, María Elvira Zú?IGA

期刊论文

Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

null

期刊论文

Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

期刊论文

Soy food consumption in relation to breast cancer modified by menopause status

YANG Rong, ZHANG Bin, YANG Shaoping, ZHANG Dan, DU Yukai

期刊论文

How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

期刊论文

Transformer2 proteins protect breast cancer cells from accumulating replication stress by ensuring productive

Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott

期刊论文

Medical applications of phytoestrogens from the Thai herb

null

期刊论文

纤维基质——乳腺癌检测和治疗的新途径

Rasha Rezk, Raquel Marín-García, Annica K.B.Gad

期刊论文

Effect of lanthanum chloride on growth of breast cancer cells and regulation of transcription

Xue LI MM , Ping HE MM , Jie XIA MM , Shiwei SONG BS , Jinhai LU BM , Yunde LIU MM ,

期刊论文

Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

null

期刊论文

京公网安备 11010502051620号京ICP备11030251号-2

关注我们